Amantadine
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Molecule Summary
| Uses | Parkinson'S Disease |
| Therapy | Anti-Parkinsonian |
| Side Effects | Headache, Nausea, Vomiting, Swelling of Ankles |
Assurance
available
Regulated
Molecule Description
The medicine is useful for treating both Parkinson’s disease and viral infection, mainly Influenza A virus (i.e., H1N1, H2N2, and H3N2).
Uses
To treat Parkinson’s disease.
Contraindications
When should one not use Amantadine
- If you are allergic to Amantadine
- History of Epilepsy or other seizure disorders
- Severe kidney disease
- History of ulcer in the stomach or small intestine
Side effects
Common side effects of this drug are:
- Light headedness
- Dizziness
- Nervousness
- Anxiety
- Agitation
- Insomnia
- Loss of appetite
- Irritability
- Hallucinations (seeing, hearing, feeling, smelling, or tasting things that are not there), difficulty in concentration
- Decrease in sexual activity
- Constipation
- Dryness of mouth
- Blurred vision
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Talk to your doctor if:
- You suffer from any liver or kidney disease or heart and blood vessels problems
- Have any mental health problem like schizophrenia, dementia, hallucinations
- Have glaucoma (increased pressure in the eye)
- If your child is under three years of age (Amantadine is not for children under the age of 3 years)
Mode of Action
How Does It Work?
For treatment of Influenza-It mainly acts on Influenza A virus (i.e., H1N1, H2N2, and H3N2). It works by blocking the protein called M2 present in virus, thereby blocking the release of the virus into human cells. It also acts by preventing the multiplication virus in the body. It has little or no effect in treating Influenza B infection.
For treatment of Antiparkinson activity:
Its mechanism of action is complex and not completely understood.
Overactivity of the NMDA receptor can lead to an increase in the neurotransmission and generation of parkinsonian symptoms. By blocking the NMDA receptors, it decreases the overactivity of the NMDA receptor and prevents the parkinsonian symptoms.
Interactions
Interactions with other medicines
- Thioridazine: Taking this medicine along with Amantadine can cause tremor to worsen in patients suffering from Parkinson’s disease.
- Anticholinergic medicines such as Scopolamine, Hydrochlorothiazide, Quinidine, Quinine, stimulant medicines, e.g., Caffeine, Methylphenidate, Pseudoephedrine, or Triamterene, should be avoided while on Amantadine because these medicines increase the risk of the side effects of Amantadine.
Dosage
Overdose
Inform your doctor immediately in case of overdose.
Missed a Dose
Take the missed dose as early as you remember. If it is the time for next dose, skip the missed dose and follow your regular dosing schedule. If you consider Amantadine for flu, you should take the complete course even if you feel better. The full course helps in eradicating infection.
Frequently Asked Questions (FAQs)
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