Enzomac Plus Tablet
10 Tablet(s) in Strip
Product Summary
Enzomac Plus Tablet, from Macleods Pharmaceuticals, combines diclofenac 50 mg, rutoside 100 mg, bromelain 90 mg and other anti-inflammatory enzymes to treat pain and inflammation in arthritis or after injury or surgery. Diclofenac reduces substances involved in pain and inflammation. The enzymes and rutoside help reduce tissue swelling.
Medically Reviewed by Dr. Ritu Budania
Last updated on: 13 October 2026 | 1:53 PM (IST)
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MACLEODS PHARMACEUTICALS
Dose Form
TABLET
Expiry
General Information
| Therapy | Analgesic, anti-inflammatory |
| Composition | Rutoside(100.0 Mg)+Diclofenac(50.0 Mg)+Chymotrypsin-Trypsin(48.0 Mg)+Bromelain(90.0 Mg) Rutoside 100.0 Mg+Diclofenac 50.0 Mg+Chymotrypsin-Trypsin 48.0 Mg+Bromelain 90.0 Mg |
Rutoside 100.0 Mg+Diclofenac 50.0 Mg+Chymotrypsin-Trypsin 48.0 Mg+Bromelain 90.0 Mg
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*Offer applicable on orders above ₹1000About Enzomac
Enzomac Plus Tablet is used to treat pain and inflammation caused by conditions like osteoarthritis, which leads to joint pain, especially in the knees, hips, hands, neck, and lower back, and rheumatoid arthritis, which mainly affects the hands and feet. It may also help relieve toothache, ear pain, sore throat, muscle pain, and backache.
Enzomac Plus Tablet contains Trypsin, Bromelain, Rutoside, and Diclofenac. Trypsin and Bromelain reduce pain and swelling by increasing blood flow to the affected area and promoting healing. Rutoside helps prevent swelling and inflammation by neutralizing chemicals that cause cell damage. Diclofenac blocks the release of substances that cause pain and swelling.
Take Enzomac Plus Tablet exactly as your doctor prescribes. Common side effects can include nausea, vomiting, stomach pain, indigestion, heartburn, upset stomach, diarrhea, and headache. These side effects are usually mild and go away on their own. If any of these symptoms persist or worsen, see your doctor right away.
Consult your doctor if you are pregnant or breastfeeding. Enzomac Plus Tablet is not suitable for children under 12 years old. This medication may cause dizziness, so do not drive or operate heavy machinery until you feel alert. Keep your healthcare provider informed about your health and any medications you are taking to avoid potential interactions or side effects.
A combination of bromelain, trypsin, rutoside, and diclofenac is also present in Enzoheal D tablet, Thrize Plus tablet, Xymoheal D tablet, Zymoflam D tablet, and Tibrolin D tablet.
Uses
Contraindications
- If you are allergic to Bromelain, Trypsin, Rutoside, Diclofenac or any other component of Enzomac Plus tablet.
- If you have a blood disorder (Hemophilia) or liver disorder.
- If you have a kidney disorder and are undergoing hemodialysis.
- If you have active stomach or intestinal bleeding, ulcer, perforations or peptic ulcers.
- If you have a history of stomach, intestinal bleeding or perforations.
- If you have any heart conditions such as heart failure.
Side effects
- Headache
- Dizziness
- Indigestion
- Nausea
- Vomiting
- Abdominal discomfort
- Rash
- Fatigue
Precautions and Warnings
Alcohol
UNSAFENo, you should not consume alcohol with Enzomac Plus tablet, it can increase the risk of stomach irritation and thus bleeding. It is recommended to talk to your doctor if you consume it often.
Pregnancy
UNSAFEThe use of this medicine is not recommended during pregnancy unless prescribed by the doctor after considering it to be safe and necessary particularly during the last 3 months of pregnancy.
Breastfeeding
WITH CAUTIONEnzomac Plus tablet might pass into breast milk and it may cause harm to the newborn baby. Hence, you should not consume this medicine if you are breastfeeding, unless considered safe and necessary by your doctor.
Driving
WITH CAUTIONIf you experience dizziness, headache after taking Enzomac Plus tablet then avoid driving.
Other General Warnings
- You have liver or kidney disease.
- You have heart disease, as Enzomac Plus tablet can cause an increase in heart rate.
- You have or had any medical condition and are on medication for the same.
- You experience any side effect after taking Enzomac Plus tablet.
- You have a stomach or an intestinal ulcer.
- You have a blood disorder or pre-existing asthma.
- Enzomac Plus tablets should not be used for children below 18 years of age.
Directions for use
- Enzomac Plus tablet should be taken as directed by your doctor. Swallow it whole with a glass of water.
- Take it at a fixed time for optimal results. Do not consume it more than what is prescribed by your doctor.
Storage and disposal
- Store at temperature below 30°C in a cool dry place.
- Keep out of reach of children and pets.
Quick tips
- Enzomac Plus tablet aids to provide relief from pain and inflammation associated with various conditions.
- Be sure to take your medication exactly as directed. Don't take more or less than the recommended dose.
- Inform your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding before taking this medicine.
- Inform your doctor if you are allergic to Bromelain, Trypsin, Rutoside, Diclofenac, or any other component of the Enzomac Plus tablet.
- Talk to your doctor if you experience any side effects after taking this medicine.
- Enzomac Plus tablets should not be used for children below 18 years of age.
- Take this medicine with or after meals to avoid stomach upset.
- Avoid alcohol intake while taking this medicine as it can increase the risk of stomach irritation and thus bleeding.
Dosage
Overdose
- Excess of Enzomac Plus tablet can cause symptoms such as headache, nausea, vomiting, chest pain, stomach or intestinal bleeding, diarrhoea, dizziness, excitation, coma, drowsiness, fainting or convulsions.
- However, if you have taken too much of Enzomac Plus tablet then contact your doctor or reach out to the nearest hospital immediately.
Missed a dose
How Enzomac works
- In Enzomac Plus tablet, Trypsin & Bromelain have anti-inflammatory properties. It acts by increasing the blood supply to the affected area, thereby reducing pain and swelling. Additionally, it decreases the movement of inflammatory cells, which enhances the healing process.
- Rutoside has antioxidant and anti-platelet aggregation properties, which prevent the formation of free radicals and thus prevent cell damage, while also inhibiting the aggregation of platelets. This further improves blood circulation and accelerates wound healing.
- Diclofenac inhibits the synthesis of prostaglandins, chemical substances responsible for causing pain, swelling, and inflammation, thereby offering anti-inflammatory properties.
Interactions
Interactions with other medicines
- Certain medicines can interfere with the action of Enzomac Plus Tablet, or this medicine itself can affect the action of other medicines taken at the same time.
- Always inform your doctor about all the medicines you are taking, which includes all prescribed or non-prescribed herbal medicines, dietary supplements, as well as other treatments you are taking for any disorder.
- In particular, if you are taking certain medications, such as immunosuppressants (such as Ciclosporin and Tacrolimus), medicines used for brain and heart-related diseases, anti-epileptics, antibiotics like Ciprofloxacin, medicines for reducing stomach acid, anti-coagulants, and certain supplements containing iron and calcium, etc.
- Enzomac Plus tablets may alter the effect of an antibiotic, such as Amoxicillin, when used concomitantly.
- Medicines known to retain potassium levels in the blood, such as Spironolactone, Ciclosporin, Tacrolimus, or Trimethoprim, should be used with caution and monitored.
- Taking any other medicine containing Diclofenac or NSAIDs and Citalopram, Sertraline (mood enhancer) increases the risk of stomach or intestinal bleeding.
Food interactions
Frequently asked questions
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References
- Bromelai [Internet]. Nccih.nih.gov. 2021 [cited 4 April 2022]
- Diclofenac Sodium 50mg Gastro-Resistant Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 4 April 2022]
- Diclofenac Sodium 50mg Gastro-Resistant Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 4 April 2022]
- DrugBank. Bromelain. DrugBank [Internet]. 2024 [cited 30 December 2024].
- DrugBank. Chymotrypsin [Internet]. 2024 [cited 30 December 2024]
- ScienceDirect. Chymotrypsin. ScienceDirect [Internet]. 2024 [cited 30 December 2024]
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