Cosvate GM Cream
25g Cream in Tube
Product Summary
Cosvate Gm Cream, from Eris Life Sciences, combines 0.05% w/w clobetasol propionate, 0.1% w/w gentamicin and 2% w/w miconazole nitrate for inflamed skin conditions with fungal or bacterial infection. The steroid reduces inflammation, while the antibacterial and antifungal agents block susceptible microbes.
Medically Reviewed by Dr. Ritu Budania
Last updated on: 13 October 2026 | 10:48 AM (IST)
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Dose Form
CREAM
Expiry
General Information
| Therapy | Topical antimicrobial and steroid |
| Composition | Clobetasol Propionate(0.05 %W/W)+Gentamicin(0.1 %W/W)+Miconazole Nitrate(2.0 %W/W) Clobetasol Propionate 0.05 %W/W+Gentamicin 0.1 %W/W+Miconazole Nitrate 2.0 %W/W |
Clobetasol Propionate 0.05 %W/W+Gentamicin 0.1 %W/W+Miconazole Nitrate 2.0 %W/W
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*Offer applicable on orders above ₹1000About Cosvate
Cosvate-GM Cream is a prescription medication used to treat a variety of inflammatory and infectious skin conditions, including eczema, dermatitis, psoriasis, and certain autoimmune-related skin diseases. It is a triple-combination cream containing clobetasol propionate (a potent corticosteroid that reduces redness, swelling, and itching), miconazole nitrate (an antifungal that combats fungal infections), and gentamicin (an antibiotic that prevents or treats bacterial infections).
This cream is not suitable for conditions such as acne, rosacea, perioral dermatitis, itching around the anus or genitals, infected or itchy skin without a doctor’s advice, or widespread plaque psoriasis. Incorrect use of Cosvate-GM may worsen the condition or cause unnecessary side effects.
Before applying Cosvate-GM, inform your doctor if you have a history of bone-related issues, allergies to steroids, broken or damaged skin, chronic leg ulcers, or psoriasis. This helps determine whether the cream is safe for you. Extra caution should be exercised when using the cream on sensitive areas like the face, underarms, or groin.
Cosvate-GM cream should be applied exactly as prescribed, usually in a thin layer over the affected area. Do not extend the duration of use beyond what is advised, and avoid covering the treated skin with tight bandages unless instructed by your doctor. Overuse of corticosteroid creams can lead to skin thinning or other long-term side effects.
Common side effects of Cosvate-GM include burning, irritation, redness, itching, or discomfort at the application site. These effects are typically mild and temporary, but if they persist or worsen, consult your doctor immediately. Use this cream with caution during pregnancy or breastfeeding, and only under strict medical supervision.
Uses
Contraindications
- If you are allergic to clobetasol, gentamicin, miconazole, or any of the ingredients in Cosvate-GM cream.
- It should not be used for treating infection in your private parts, face, acne, around mouth and skin perforations.
- If you have any untreated skin infections or skin thinning problems.
- You should not use this cream if you have chickenpox, shingles, warts or any other wounds and skin infections.
- This medicine should not be used in children below 1 year of age and for nappy rash.
Side effects
- Burning
- Irritation
- Itching
- Allergy
- Thinning of skin
- Cracks on skin
- Redness
- Dryness
Precautions and Warnings
Alcohol
WITH CAUTIONThere is no direct interaction between alcohol and Cosvate-GM cream. However, you should avoid consuming alcohol as it can worsen the infection and delay healing.
Pregnancy
WITH CAUTIONThere is limited information about safety of Cosvate-GM cream in human pregnancy. In case you are prescribed with this cream, avoid using in larger skin areas for a prolonged duration.
Breastfeeding
WITH CAUTIONCosvate-GM cream can be used while breastfeeding only if prescribed by the doctor. It should not be applied to the breast or areas near the breast of breastfeeding mother as there can be chances of ingestion of this by a breastfed infant. Avoid using it on large areas of skin or for a prolonged period.
Driving
SAFECosvate GM cream is to be applied externally and less likely to influence your driving ability.
Other General Warnings
- You experience any allergic reactions to the skin after applying Cosvate-GM cream.
- You experience other infections after applying this cream.
- It would be best if you do not use this cream on any condition other than prescribed by your doctor.
- In case you experience any skin reactions after applying this cream, inform your doctor immediately.
- You should not apply this cream for a prolonged duration on a larger skin area or more than the prescribed duration.
- In case your eyes come in contact with this medicine, rinse your eyes with clean water immediately.
Directions for use
- Use Cosvate-GM cream as directed by your doctor and follow all the instructions.
- For external use only, apply it on healthy skin surfaces free from cuts and wounds.
- Wash your hands before and after using Cosvate GM cream unless your hands are the area to be treated.
- Apply a thin layer and rub gently to cover the affected area for days and times advised by your doctor.
- If you do not see any improvement in your condition within 15 days, you should consult your doctor.
Storage and disposal
- Store Cosvate-GM cream below 25°C, protected from moisture, sun light and heat.
- Keep the medicine away from children and pets.
Quick tips
- Do not use more than the prescribed amount of Cosvate GM cream, or do not use it for longer periods of time than recommended by your doctor.
- Wash your hands before and after using this medicine. If your eyes come in contact with this cream, then rinse your eyes with clean water immediately.
- Do not give this medicine to anyone else, even if they have the same condition as you do.
- If you experience any allergic reactions after using this medicine, talk to your doctor immediately.
- Do not use this medicine for children below 1 year of age.
Dosage
Overdose
Missed a dose
How Cosvate works
- During inflammation or infection of the skin, the body releases some chemical substances which make the skin red, itchy and swollen.
- Clobetasol is a steroid which acts by blocking the synthesis of natural substances, i.e. prostaglandins, which are responsible for itching, swelling and redness.
- Miconazole works by inhibiting the formation of a fungal cell wall component, which leads to altered permeability and growth of fungus, causing infection.
- Gentamicin is an antibiotic agent which is widely used for treating various bacterial infections of the skin. It works by inhibiting the growth and multiplication of bacteria causing infection.
- Collectively, all these medicines work more effectively by reducing the infection and inflammation of the skin.
Interactions
Drug interactions of Cosvate with other medicine salt
Food interactions
Frequently asked questions
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References
- Dermovate Cream - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 1 April 2022]
- DailyMed - Gentamicin Sulfate cream [Internet]. Dailymed.nlm.nih.gov. 2022 [cited 1 April 2022]
- Dermovate Cream - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 1 April 2022]
- Chaves BJ, Tadi P. Gentamicin. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. [Accessed 27 Dec. 2024].
- Gentamicin [Internet]. ScienceDirect Topics. [Accessed 27 Dec. 2024].
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 4189, Miconazole. Retrieved December 27, 2024
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5311051, Clobetasol. Retrieved December 27, 2024
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