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Zofer Inj 2ml

2ml Injection in Ampoule
MRP 12.80
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Ondansetron(4.0 Mg)
Therapeutic classification

Medical Description

Zofer Injection contains Ondansetron. It is used to control nausea and vomiting.

Uses of Zofer Inj 2ml

Zofer Injection is used to prevent and manage nausea and vomiting induced due to chemotherapy and radiotherapy. It is also used to relieve symptoms of nausea and vomiting before and after surgeries and operations.
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Contraindications of Zofer Inj 2ml

  • If you are allergic to ondansetron or any of the other ingredients of this medicine.
  • If you are taking a medicine called Apomorphine, which is used to treat the loss of muscle control and muscle stiffness in Parkinson's disease.

Side effects of Zofer Inj 2ml

  • Headache
  • Hiccups
  • Fits
  • Constipation
  • Flushing
  • Low blood pressure
  • Sensation of warmth
  • The local reaction at the injection site

Precautions and Warnings of Zofer Inj 2ml


Can Zofer Injection be given during pregnancy?
Zofer Injection must not be used during pregnancy, especially in the first trimester of pregnancy, as it can induce the risk of a baby being born with cleft lip and/or cleft palate (splits in the upper lip). If you are pregnant or think you may be or are planning for a baby, then consult your doctor before starting this medicine. Women of childbearing age should use birth control measures while taking this medicine to avoid pregnancy.

Breast Feeding

Can Zofer Injection be given while breastfeeding?
This medicine passes into human milk and could harm the breastfed baby. Hence, it is recommended to consult the doctor while using this medicine in lactating mothers.


Can I drive if I have been given Zofer Injection?
Zofer Injection does not affect your driving ability. In case, you experience visual disturbances and drowsiness after taking this medicine, then avoid driving.


Can I consume alcohol with Zofer Injection?
There is limited information about the interaction of Zofer Injection with alcohol, but avoid taking alcohol, as it can induce vomiting and nausea. It can also increase the chances of getting side effects like drowsiness and dizziness.

Other General Warnings

Talk to your doctor if
  • You are allergic to similar medicines like Granisetron or Palonosetron.
  • You have severe constipation or have a blockage in your stomach as this medicine can affect the food transit time through the digestive tract.
  • You had or have heart problems like heart failure or irregular heartbeats.
  • You have any liver problems.
  • You have a condition of salt imbalance in your blood or dehydration or you are experiencing fluid loss.

Mode of Action of Zofer Inj 2ml

How Does It Work?

Zofer Injection works by inhibiting the action of a chemical substance known as serotonin. Serotonin is responsible for inducing nausea and vomiting. Ondansetron binds to a receptor known as 5-HT₃, thus inhibits the binding of serotonin to it and prevents vomiting and nausea.
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Directions for Use of Zofer Inj 2ml

Zofer Injection will be given to you by a doctor or nurse. Do not self-inject.

Interactions of Zofer Inj 2ml

Interactions with other medicines

  • Be cautious if you are taking medicine like Amiodarone for uneven heartbeats or arrhythmias.
  • You may experience irregular heart rhythm if you take medicines like Doxorubicin, Trastuzumab, antihypertensive medicine such as Atenolol or Timolol, antimalarial medicine such as Halofantrine, antibiotic medicine like Erythromycin and antifungal medicine like Ketoconazole.
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  • You may experience low blood pressure and unconsciousness if you take Zofer Injection along with Apomorphine. Hence, these medicines should not be used together.
  • Medicines used to relieve pain like Tramadol may not work when taken along with Zofer Injection injection.
  • You may experience serotonin syndrome (symptoms like high body temperature, irritation, shakiness, sweating, widened pupils and diarrhoea), including abnormal mental state with medicines used to treat mental states like Citalopram or Sertraline.
    Read less
  • Other medicines like Phenytoin, Carbamazepine & Rifampicin may affect the action of Zofer Injection injection.

Storage and disposal of Zofer Inj 2ml

  • Keep the injection in the original pack, protect from light
  • Discard any unused portion of injection properly

Dosage of Zofer Inj 2ml


Your doctor or nurse will give this injection to you in the hospital or clinic. Therefore, it is less likely to provide you with an overdose of this medicine. However, if you experience visual disturbances, constipation, low blood pressure and abnormal heart rhythm. If you think you have taken too much of this medicine, then contact your doctor immediately or visit the nearest hospital.
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Missed a Dose

Your doctor or nurse will monitor you on when the injection should be given to you, thus it is unlikely that the dose will be missed. However, if you think your doctor or nurse might have missed a dose, then inform them.
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Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Zofer InjectionI?

  • Inform your doctor about your detailed medical & surgical history.
  • Inform your doctor if you have liver or stomach disease.
  • Inform your doctor if you are pregnant, breastfeeding or planning to have a baby.

Q: Is Zofer Injectionsedative?

A: No, Zofer Injectionis not known to cause any sedative effect.

Q: What is Zofer Injectionused for?

A: Zofer Injectionis used to manage nausea and vomiting during cancer chemotherapy and radiotherapy. It helps in preventing post and pre-operation/surgery emesis.

Q: Can Zofer Injectionbe given during pregnancy?

A: No, it should not be given to a pregnant woman, especially in the first three months of pregnancy.

Q: Is Zofer Injectionuseful for motion sickness?

A: No, it should not be used for motion sickness.
Last Updated on: 20 Mar 2021 | 09:47 AM (IST)
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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