Vicox 2 Tablet
By SHRINIVAS GUJARAT LABORATORIES PVT LTD
10 Tablet(s) in Strip
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Description
Vicox 2 contains two active medicines, Rifampicin and Isoniazid. It is a combination of two antibiotics that are used to manage tuberculosis. Tuberculosis (TB) is a common, prevalent infectious di
sease in India. It is caused by Mycobacterium tuberculosis. It primarily affects the lungs, known as pulmonary tuberculosis. In lung TB, patients present with coughs with sputum production lasting for more than two weeks, evening fevers, night sweats, and weight loss. TB is a chronic, severely debilitating infection that requires sustained treatment. The first-line therapy of TB involves the medications Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in appropriate doses. Vicox 2 FDC is a combination of 2 of these medicines in a fixed-dose in one tablet. Rifampicin kills bacteria inside and outside the cell, responsible for 99% killing of tuberculosis bacteria. It kills organisms that are replicating at a slow or intermittent pace. Isoniazid acts against rapidly growing bacteria by preventing bacterial cell wall formation.
Product Summary
| Offer Price | ₹64.60 |
| You Save | ₹20.40 (24% on MRP) |
| Contains | Rifampicin(450.0 Mg)+Isoniazid(300.0 Mg) |
| Uses | Treatment of Tuberculosi |
| Side effects | Nausea, vomiting, abdominal pain, itching, headache, drowsiness, giddiness, fatigue, discolouration of urine/ secretions/ faeces, liver dysfunction, kidney dysfunction, visual changes, peripheral nerve disorders. |
| Therapy | ANTI-TUBERCULAR |
Uses
- Management of tuberculosis
Contraindications
- Patients who are hypersensitive to rifampicin, isoniazid or any of the other contents of this tablet.
- It is contraindicated in persons with liver disease or jaundice.
- It is to be used with caution in the case of intravenous substance users.
- Patients with Kidney disease.
- Pregnancy
- Patients having tingling, numbness, or any signs of peripheral nerve damage (neuropathy)
Side effects
- Headache
- Nausea
- Skin rashes with or without itching
- Urticaria (a skin condition with elevated red lesions on the skin)
- Vomiting
- Dizziness
- Orange-red colour urine
Precautions and Warnings
Pregnancy
Q:
Can I take Vicox 2 during pregnancy?
A:
This medication is unsafe during pregnancy. Its use can result in bleeding in the infant after delivery. Inform your doctor regarding your pregnancy or intention to conceive at the time of prescription of Vicox 2.
Breast Feeding
Q:
Can I take Vicox 2 while breastfeeding?
A:
This medication is unsafe during breastfeeding as it can be transferred to the infant via breast milk. Inform your doctor if you are breastfeeding at the time of prescription of Vicox 2.
Driving
Q:
Can I drive if I have taken Vicox 2?
A:
Isoniazid has been associated with vertigo, visual disorders and psychotic reactions. It is not advisable to drive or operate any other heavy machinery when using this medication
Alcohol
Q:
Can I consume alcohol with Vicox 2 ?
A:
It is not advisable to drink when using this medication, resulting in severe side effects. Daily consumption of alcohol with Vicox 2 also increases the chances of liver damage.
Other General Warnings
Talk to your doctor if
- Both Rifampicin and Isoniazid causes liver dysfunction, so use with physician advice in liver disease
- Rifampicin may produce a discolouration (yellow, orange, red, brown) of the teeth, urine, sweat, sputum and tears.
Mode of Action
How Does It Work?
Rifampicin works by blocking a bacterial enzyme called RNA Polymerase. This enzyme is needed for the bacteria to grow and divide. It is also needed to produce proteins that are essential for survival. Hence the inactivation of this enzyme kills the bacteria.
Isoniazid works by acting on a chemical called Mycolic acid. This is an important content of the cell wall that protects the inner content of the bacteria. When this wall is weakened, the bacteria become more vulnerable to immune responses....
Directions for Use
- This medication should be taken as prescribed by the prescribing doctor.
- It is recommended to take this medication on a regular schedule at the same time every day for optimal effects of this medication.
- Do not crush, chew or break this tablet. Swallow it entirely with a glass of water.
- This tablet should ideally be taken without food to ensure maximum absorption.
Interactions
Interactions with other medicines
- Rifampicin is a potent inducer of a particular enzyme system involved in the metabolism of other medications. Dose adjustment may be needed in case of chronic use of any medications. For example, painkillers such as morphine....
- Antacids (used in case of heartburn or stomach ulcers to reduce acid production) reduce the amount of rifampicin and isoniazid absorbed from the gut to the bloodstream. These include omeprazole, pantoprazole, etc....
- Corticosteroids can reduce the plasma levels of isoniazid as they increase its metabolic and excretion.
- There are increased chances of toxicity due to high doses of paracetamol in patients taking Vicox 2.
- Vicox 2 affects the blood levels of medications used in the treatment of seizures (fits), such as carbamazepine and phenytoin. The dose of these tablets has to be adjusted accordingly.
- It reduces the efficacy of ketoconazole, an antifungal medication.
Interactions with food items
- The content of isoniazid interacts with certain types of wine and cheese due to a high level of tyramine content in them.
- Also avoid foods rich in histamine, such as tuna. Taking these foods with the tablet can result in flushing (redness of skin), reduced blood pressure, headache, and sweating.
Storage and disposal
Store the tablet in a cool and dry place away from direct light and moisture. Keep the tablets out of reach of children and pets. Discard the medicine after the date of expiry mentioned on the packaging. Do not flush the medication down the toilet. Dispose of it with biomedical waste only....
Dosage
Overdose
An accidental or suspected overdose may present with symptoms including nausea, vomiting, dizziness, itching, severe stomach ache, breathing difficulties, delirium (confusion, deranged attention), and can progress to loss of consciousness or even death. It is advisable to rush the patient to the nearest hospital for emergency care....
Missed a Dose
If you miss a dose of this tablet, it is advised to take it as soon as possible. If the duration missed is too long, and it is almost time for the next dose, it is recommended to skip the missed dose. Do not double the dose of the tablet.
The tablet needs to be taken daily as prescribed to ensure disease clearance....
Content Details
WRITTEN BY
REVIEWED BY
Dr. Bhavika Shah
MBBS, MD (Dermatology), DNB (Dermatology)
Frequently Asked Questions (FAQs)
Q: I have had a cough for the last week. Can I take this tablet?
A: No, this tablet is only used for the treatment of cough due to tuberculosis. Please visit a doctor to find the cause of the cough and start the appropriate treatment
Q: I was recently diagnosed with fatty liver. I am taking this tablet for tuberculosis. Can I continue it?
A: Always consult your doctor in the case of any side effects or problems during treatment for tuberculosis. Certain blood tests and dose adjustments may be required.
Q: My doctor asked me to take this tablet on an empty stomach, which made me nauseous. What do I do?
A: Nausea is a common side effect of Vicox 2. Consult your doctor to understand what is the best way to manage it
References
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Product Details
Brand
VICOX
Expires on or After
18/09/2025
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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