Vicox 2 Tablet

• Management of tuberculosis

• Patients who are hypersensitive to rifampicin, isoniazid or any of the other contents of this tablet.
• It is contraindicated in persons with liver disease or jaundice.
• It is to be used with caution in the case of intravenous substance users.
• Patients with Kidney disease.
• Pregnancy
• Patients having tingling, numbness, or any signs of peripheral nerve damage (neuropathy)

• Headache
• Nausea
• Skin rashes with or without itching
• Urticaria (a skin condition with elevated red lesions on the skin)
• Vomiting
• Dizziness
• Orange-red colour urine

Other General Warnings

• Both Rifampicin and Isoniazid causes liver dysfunction, so use with physician advice in liver disease
• Rifampicin may produce a discolouration (yellow, orange, red, brown) of the teeth, urine, sweat, sputum and tears.

• This medication should be taken as prescribed by the prescribing doctor.
• It is recommended to take this medication on a regular schedule at the same time every day for optimal effects of this medication.
• Do not crush, chew or break this tablet. Swallow it entirely with a glass of water.
• This tablet should ideally be taken without food to ensure maximum absorption.

Overdose

Missed a Dose

How Does It Work?

Interactions with other medicines

• Rifampicin is a potent inducer of a particular enzyme system involved in the metabolism of other medications. Dose adjustment may be needed in case of chronic use of any medications. For example, painkillers such as morphine.
• Antacids (used in case of heartburn or stomach ulcers to reduce acid production) reduce the amount of rifampicin and isoniazid absorbed from the gut to the bloodstream. These include omeprazole, pantoprazole, etc.
• Corticosteroids can reduce the plasma levels of isoniazid as they increase its metabolic and excretion.
• There are increased chances of toxicity due to high doses of paracetamol in patients taking Vicox 2.
• Vicox 2 affects the blood levels of medications used in the treatment of seizures (fits), such as carbamazepine and phenytoin. The dose of these tablets has to be adjusted accordingly.
• It reduces the efficacy of ketoconazole, an antifungal medication.

Interactions with food items

• The content of isoniazid interacts with certain types of wine and cheese due to a high level of tyramine content in them.
• Also avoid foods rich in histamine, such as tuna. Taking these foods with the tablet can result in flushing (redness of skin), reduced blood pressure, headache, and sweating.