Apolipoprotein A-1 Test

High Cholesterol and Triglycerides or Cardiovascular disease

The Apolipoprotein A1 test procedure is carried out to determine the levels of Apo- A1 in your system. It also helps determine the risk of developing cardiovascular diseases.

Apolipoprotein A-1 is a very important protein in the body as it has specific roles in the transportation and metabolism of lipids. It is also the main protein component in high-density lipoprotein, which is known as good cholesterol.

It is also important to understand that lipids alone cannot dissolve in the blood. They are like the oil that floats on water. Apolipoproteins combine with lipids to form lipoprotein particles that can be transported into the bloodstream. Without Apolipoproteins, it is difficult for the lipids to get into the bloodstream alone. This is because Apolipoproteins provide structural integrity to lipoproteins and protect the water-repellent lipids at their centre.

The two main lipids are triglyceride and cholesterol-rich. They are carried by Apolipoproteins throughout the body for the consumption of the cells. However, high-density lipoprotein (HDL) is like an empty cab. It goes out of the tissues and picks up excess cholesterol to transport it back to the liver. The liver recycles the cholesterol for future use or excretes it through the bile.

The reverse transport of the HDL is the only way the cells can get rid of excess cholesterol. Reverse transport also helps protect the arteries. Also, if an adequate amount of HDL is present, it can reverse the build-up of fatty plaques and deposits resulting from Atherosclerosis which can lead to chronic cardiovascular diseases.

Also, it is important to understand that Apolipoprotein is the cab driver. It recharges the enzymes that load cholesterol from the tissues into HDL. They also allow HDL to be recognised and bound by receptors in the liver at the end of the transport. There are two types of Apolipoproteins found in the body; Apo- A1 and Apo- A2. However, Apo- A1 is found in greater proportion as compared to Apo- A2.

The concentration of Apo- A1 can be measured directly with the help of the Apolipoprotein A1 test. Also, the levels of the same are directly proportional to the levels of HDL. Deficiencies of Apo- A1 can lead to risks of developing cardiovascular diseases. Based on the Apolipoprotein A1 test results, the doctor can evaluate the risk of cardiovascular diseases in your body.

The doctor will also take the Apolipoprotein A1 profile test if you have a family history of abnormal lipid levels or premature cardiovascular conditions. You will further be asked to take the test if your doctor is trying to determine the cause of high cholesterol in the body.

Usually, the Apolipoprotein A1 profile test will be ordered with the Apo B test to evaluate the good and bad cholesterol. Apo- A1 test is also included in the complete lipid profile test.

Low HDL levels are a common problem in India. It is mostly because of unhealthy lifestyle practices. It is commonly found that 72% of Indians have low HDL levels. These people were also found with Apolipoprotein A1 deficiencies. The major cause of this is a poor diet.

Other Names of the Apolipoprotein A1 Test

This test is also known by the name Apo A-1 Test.

What does the Apolipoprotein A1 Test detect/measure and who is it prescribed for?

The Apolipoprotein A1 test measures the levels of Apo- A1 proteins in the body.

Abnormal Apolipoprotein A1 levels can result in:

• High cholesterol levels
• Cardiovascular diseases
• Losing weight
• Chronic kidney or renal failure
• Coronary Artery Disease

The Apolipoprotein A1 profile test is prescribed if:

• You have a family history of abnormal lipids
• You have a family history of cardiovascular diseases
• You have genetic disorders
• You have uncontrolled diabetes

After the diagnosis, your physician will prescribe you a treatment for your abnormal Apo- A1 protein levels or Apo- A1 proteins deficiency. Following that, you will have to take the Apolipoprotein A1 test every 3 months to check the medication’s efficiency.

The Apolipoprotein A1 test is applicable for males and females, adults and children. Cigarette smoking and certain medicines like Niacin, Statin, Diuretics and medicines with estrogen or androgen can affect the results of this test.

The normal ranges are:

• Men - 94 to 178 mg/dL
• Women - 101 to 199 mg/dL

There may be a minimal difference in the normal values between males and females, but the range remains constant.

Low levels of Apo- A1 means that you have low levels of HDL too. This can lead to a lot of cardiovascular diseases. High levels of Apo- A1 are considered protective. In this case, it is not related to HDL levels.

If the results of the Apolipoprotein A1 test are lesser than the normal range, then it may be associated with:

• Smoking
• Obesity
• Uncontrolled diabetes
• Chronic kidney disease
• Uses of drugs like beta-blockers, androgens, progestins and diuretics
• Tangier disease which is a rare inherited disorder
• Nephritic Syndrome, which is a group of kidney problems
• Cholestasis, which is associated with the flow of bile from the liver
• Hepatocellular disorders
• Coronary artery disease

If the Apolipoprotein A1 test results are higher than the normal range, then it may be associated with:

• Use of Statins
• Pregnancy
• Weight Reduction
• Physical Exercise
• A genetic disorder called Familial Cholesteryl Ester Transfer Protein Deficiency (CETP)

Thus, it is vital to consult an experienced doctor once you get the results of the Apolipoprotein A1 test. The doctor might ask you to take additional tests to confirm the diagnosis of certain conditions.

The results of the Apolipoprotein A1 Test are based on the analysis of the blood sample.

Test Preparation

Apolipoprotein A1 test requires 10-12 hours of overnight fasting. Only water is allowed during this period. Also, refrain from consuming beverages like coffee, tea and milk until the Apolipoprotein A1 test procedure is completed. Also, inform your doctor before the test about your medications, as some of them can hinder the test results.

The usual way to collect the blood sample is by drawing it from one of the prominent veins of the forearm. The procedure will last for 5-10 minutes only.

Test Inclusions: What Parameters Are Included?

The levels of Apolipoprotein A-1 are tested in this test. There are no positive or negative results of this test. It determines a normal range or an abnormal range with the help of the values. The Apolipoprotein profile test helps diagnose deficiency of the Apo- A1 in the body.

How Frequently Should You Take This Test?

A random Apolipoprotein A1 profile test helps determine abnormal Apo- A1 protein levels in your system. Based on the protein count, the results of the Apolipoprotein A1 test will confirm issues with the heart. If the diagnosis is confirmed, then the doctor will put you on medication. After that, the test should be taken every three months to monitor the progress of the level in the body.

If your results are normal, you will be asked to take the Apolipoprotein A1 test annually with the complete lipid profile test.