Trental 400 Tablet
By SANOFI
15 Tablet(s) in Strip
₹49.55
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₹72.87
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₹3.3/tablet
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Description
Trental 400, which contains pentoxifylline as the active ingredient, is a medication primarily used for the treatment of peripheral vascular disease. This condition is characterised by poor blood circulation to the limbs, leading to symptoms like intermittent claudication (leg pain during walking) and rest pain, particularly at night. It works by decreasing the viscosity of the blood, making it less thick and allowing it to flow more easily through the blood vessels. This enhanced circulation helps to alleviate the pain and discomfort associated with inadequate blood supply to the arms and legs.
Before starting treatment with Trental 400, it is crucial to consult a healthcare professional. You should inform your doctor about any pre-existing medical conditions, such as heart problems, low blood pressure, or kidney disease, as the medication should be used with caution in these cases. It is also essential to disclose all other medications, supplements, and herbal products being taken, as Trental 400 may interact with them. It may potentiate the effects of blood pressure medications and antidiabetics, and may increase the risk of bleeding when taken with blood thinners or certain pain relievers.
The recommended dosage and duration of Trental 400 are determined by the prescribing doctor. It is vital to adhere to these instructions and not to stop or modify the dose without professional guidance, even if symptoms improve. Abruptly discontinuing the medication can lead to a worsening of the condition or the reappearance of symptoms. Trental 400 should be taken with or after a meal to reduce the risk of an upset stomach. For optimal results, it should be taken at the same time each day.
While Trental 400 is generally well-tolerated, some individuals may experience side effects, including nausea, indigestion, dizziness, or headaches. These side effects are often temporary and may improve as the body adjusts to the medication. It is important to be aware of more serious, though rare, side effects like irregular heartbeat, chest pain, or allergic reactions. If any severe or persistent side effects are experienced, or if an overdose is suspected, immediate medical attention is necessary.
Product Summary
| Offer Price | ₹49.55 |
| You Save | ₹23.32 (32% on MRP) |
| Contains | Pentoxifylline(400.0 Mg) |
| Uses | Peripheral vascular disaese |
| Side effects | Irregular heartbeat, chest pain, dizziness, headache |
| Therapy | DRUGS FOR PERIPHERAL VASCULAR DISEASE |
Uses
Trental 400 tablet is used to treat poor circulation of blood flow to the limbs.
Contraindications
- If you are allergic to Pentoxifylline or similar medicines like Aminophylline or any other ingredients of Trental 400 tablet.
- If you have a heart problem like chest pain, irregular or fast heartbeat.
- If you have or had bleeding in the eye or bleeding in the brain (stroke).
Side effects
- Irregular heartbeat
- Chest pain
- Dizziness
- Headache
- Eyes pain
- Stomach pain
- Diarrhoea
- Constipation
- Vomiting
- Nausea
- Bloating
Precautions and Warnings
Pregnancy
Q:
Can I take Trental 400 tablet during pregnancy?
A:
There is limited information on the use of this medicine in pregnancy. Hence, it is recommended not to use the same unless prescribed by your doctor.
Breast Feeding
Q:
Can I take Trental 400 tablet while breastfeeding?
A:
It passes into the breastmilk in a very small amount. Breastfeeding women should take this medicine only if the potential benefit for the mother outweighs the risk to the breastfed baby.
Driving
Q:
Can I drive if I have consumed Trental 400 tablet?
A:
This medicine does not affect your ability to drive or to use machinery. However, if you experience side effects like dizziness, then avoid driving or using machines.
Alcohol
Q:
Can I consume alcohol with Trental 400 tablet?
A:
There is no known interaction with alcohol along with this medicine. Consult your physician if you have a habit of regular drinking.
Other General Warnings
Talk to your doctor if
- If you experience allergic reactions, discontinue the medicine immediately.
- You have a blood-circulation problem in the heart or suffering from low blood pressure, then this medicine should be used with caution.
- You have kidney disease, then you need to be monitored carefully. The doctor might reduce the dosage.
- You are already taking any other medicines such as blood-thinning medicines, antidiabetic medicines, antibiotics like Ciprofloxacin or Theophylline to treat respiratory problems.
Directions for Use
Trental 400 tablet should be taken as directed by your doctor. Swallow it as a whole with a glass of water, do not cut, break or chew the medicine. It would be best if you took it at a fixed time for optimal results and should not consume it more than that prescribed by your doctor. ...
Storage and disposal
- Store Trental tablets below 25°C.
- Keep it in original packing to protect it from moisture.
Quick Tips
- Trental (pentoxifylline) is a medication that helps improve blood flow in people with vascular disease, reducing symptoms such as leg cramps.
- Take Trental with or after meals. Check with your doctor or pharmacist before taking any medication. Avoid Trental if you're pregnant. Consult your doctor or pharmacist before taking Trental if you are breastfeeding or planning to breastfeed....
- Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding.
- Inform your doctor about all the medicines and supplements you take and all the conditions or diseases you suffer from before starting Trental 400 tablet.
- If you experience allergic reactions, discontinue the medicine immediately.
- Regular physical activity helps improve blood flow and strengthens the heart.
- Inform your doctor if you are already taking any other medicines, such as blood-thinning, antidiabetic, or antibiotics.
Dosage
Overdose
Symptoms of an overdose may include low blood pressure, feeling sleepy, fits (seizures) or irregular heartbeat, fever, hot flashes, aggression, etc. If you think you have taken too much of this medicine, then contact your doctor immediately or visit the nearest hospital....
Missed a Dose
If you have missed any dose of this medicine, then take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one....
Mode of Action
How Does It Work?
Trental 400 tablet works by decreasing the viscosity of blood, allowing it to pass easily through the blood vessels. Hence, it helps in enhancing the blood circulation in the arms and legs.
Interactions
Interactions with other medicines
- You are taking antidiabetic medicines like insulin along with Trental 400 tablet, which need to be monitored closely.
- If you are taking blood-thinning medicines like Heparin, Warfarin, and tirofiban simultaneously, then the anticoagulant activity needs to be monitored.
- It can potentiate the effect of medicines used to treat high blood pressure, such as Propranolol and Atenolol, so the dosage may need to be reduced.
- Simultaneous use of Trental 400 tablets and Ketorolac, a pain relief medicine, may increase the risk of bleeding.
- Concomitant use of Trental 400 tablet and Theophylline to treat respiratory problems, and Ciprofloxacin used to treat infection, may worsen the side effects.
- Other medicines, such as antacids like Cimetidine, Clopidogrel to reduce the risk of heart disease, Abciximab, and painkillers like Acetylsalicylate, should be used with caution if you are being treated with Trental 400 tablets....
Interactions with food items
It is advisable to take Trental with or after meals to minimize stomach upset.
Content Details
WRITTEN BY
Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology
REVIEWED BY
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Do I need to take any precautions during treatment with Trental 400?
- Yes, your doctor may request regular blood tests to monitor your liver function during treatment. It may affect your liver.
- You should inform your doctor if you are already taking any other medications, such as antidiabetics, blood pressure medications, or blood thinner medications. It may interfere with the activity of this medicine....
Q: How long can I take the Trental 400 mg tablet?
A: You should take the Trental for as long as a doctor has prescribed you. If you do not feel any improvement, inform the doctor but do not exceed the recommended duration without consulting a doctor.
Q: Can I stop taking Trental 400 tablet if I see improvement in condition?
A: No, do not stop or modify the dose without consulting a doctor. Otherwise, it may worsen your condition or the symptoms may reappear.
Q: Is Trental 400 a blood thinner?
A: No, it is not a blood thinner. It contains pentoxifylline that belongs to the peripheral vasodilators class of medicines, which improves blood flow.
Q: When should I take Trental 400?
A: Trental should be taken with or after a meal, as this will lessen its chances of causing an upset stomach. However, it's important to take it at the same time each day for maximum results. If you are not sure when to take it, consult the doctor.
Q: What are the side effects of Trental?
A: Nausea, indigestion, bloating, stomach discomfort, dizziness, headache etc., are a few side effects that can be observed during the treatment. However, it is not necessary that everyone experience the same. The side effects often improve as your body gets used to the medicine.
Q: Can you just stop taking Trental after relief?
A: No, Trental should not be immediately stopped after relieving the symptoms. Gradual weening of the medication should be done to avoid adverse effects.
References
View All
- Trental- Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 22nd September 2025]
- Trental tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 22nd September 2025]
- CDSCO [Internet]. Cdscoonline.gov.in. 2025 [cited 22nd September 2025]
- Trental [Internet]. Accessdata.fda.gov. 2025 [cited 22nd September 2025]
- Pentoxifylline- NCBI [Internet]. Ncbi.nlm.nih.gov. 2025 [cited 22nd September 2025]
- Annamaraju P, Patel P, Baradhi KM. Pentoxifylline. [Updated 2024 Feb 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 22nd September 2025]
- Frampton JE, Brogden RN. Pentoxifylline (oxpentifylline). A review of its therapeutic efficacy in the management of peripheral vascular and cerebrovascular disorders. Drugs. 1996 Feb;51(2):259-90. 2025 [cited 22nd September 2025]
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Product Details
Brand
TRENTAL
Country of Origin
India
Expiry Date
27/12/2025
Manufacturer Details
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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