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Paro Cr Plus Tablets

10 Tablet(s) in Strip
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Paro Cr Plus Tablets Description

Paro CR is a prescription medication used to treat depression and anxiety. It is a combination of two medications, Paroxetine and Clonazepam. Depression is a condition characterised by pervasive l

ow mood. Multiple brain pathways and chemical messengers are indicated in depression, chiefly serotonin, norepinephrine and dopamine. Anti-depressant medications target these pathways and neurotransmitters to help relieve the symptoms of depression. Anxiety is a condition characterised by increased worry and fear about routine situations. Anxiety can present with increased heart rate, sweating, restlessness, trembling, increased rate of breathing etc. Panic disorder is also a type of anxiety disorder with a feeling of loss of control and fear. It is key to note that Clonazepam has habit-forming potential. It also has the potential to be misused. Careful monitoring while on this medication is required and necessary. Paro CR should be taken as recommended by the doctor. It should not be abruptly started or stopped, as it may cause withdrawal effects. Taking the tablet at the same time every day is advisable for maximum efficacy.


Product Summary

Offer Price₹93.50
You Save₹16.50 (15% on MRP)
ContainsParoxetine(12.5 Mg) + Clonazepam(0.5 Mg)
UsesTreatment of Depression and anxiety disorders
Side effectsDry mouth, diarrhoea, nausea, drowsiness, confusion, headache.
Check more medicines with composition as Paroxetine(12.5 Mg) + Clonazepam(0.5 Mg)

Uses of Paro Cr Plus Tablets

  • As per CDSCO,
  • For treating patients with co-morbid depression and anxiety

Contraindications of Paro Cr Plus Tablets

  • If you have known Paroxetine, Clonazepam or benzodiazepine hypersensitivity, or known allergies to any components in this medication.
  • If you have abnormal heart rhythms.
  • If you have acute narrow-angle glaucoma.
  • If you have breathing problems such as obstructive sleep apnea syndrome.
  • If you have a history of mania or bipolar disorder, it can cause manic episodes.
  • If you are children or a young adult, it can increase suicidal ideation.
  • If you have a history of substance abuse.
  • If you have liver and kidney disease.
  • This medication can cause a decrease in sodium levels (hyponatremia) and must be used with caution in the elderly.
  • It can decrease the seizure threshold in epileptic patients and hence must be used very cautiously.

Side effects of Paro Cr Plus Tablets

  • Nervousness
  • Dry mouth
  • Constipation
  • Weight loss/gain
  • Nausea
  • Sweating
  • Headache
  • Sleepiness

Precautions and Warnings of Paro Cr Plus Tablets



Can I take Paro CR during pregnancy?
This medication is contraindicated in pregnancy. It is a Category D medication. Speak to your doctor about your pregnancy or intention to conceive at the time of prescription.

Breast Feeding

Can I take Paro CR while breastfeeding?
Paro CR is considered unsafe during breastfeeding as it can be transferred through breast milk.


Can I drive if I have taken Paro CR?
Paro CR can cause side effects such as drowsiness, sleepiness, fatigue, dizziness etc. Hence, driving and use of heavy machinery are not recommended.


Can I consume alcohol with the Paro CR?
Mixing alcohol with Clonazepam can cause life-threatening side effects on the user, as it can lead to respiratory depression, coma, and even death. It is strictly contraindicated.

Other General Warnings

Talk to your doctor if
  • You’ve a history of addiction or substance misuse.
  • You are taking any other medications. The ingredients of this tablet may react with several other tablets that use the same pathway of metabolism in the body.
  • You’ve a history of bipolar disorder or mania in any family member.

Mode of Action of Paro Cr Plus Tablets

How Does It Work?

Paroxetine acts on brain pathways involving the chemical messenger Serotonin. It prevents the re-absorption of serotonin by nerves causing serotonin accumulation. Serotonin helps in regulating mood an...
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Directions for Use of Paro Cr Plus Tablets

  • Paro CR should be taken as prescribed by the treating physician.
  • It is recommended to take this medication at the same time every day for the best results.
  • Swallow Paro CR as a whole. Don’t crush, chew or break this tablet.
  • It’s recommended to finish the entire course of Paro CR as prescribed by your treating doctor.
  • This medication may require 3-4 weeks for onset of action. Do not increase the dose unless advised to do so by a doctor.
  • Abrupt stoppage of Paro CR can cause withdrawal side effects. Consult your doctor before stopping this medication.

Interactions of Paro Cr Plus Tablets

Interactions with other medicines

  • Avoid alcohol, opioids, or any other CNS depressant, as it can cause worsening of side effects such as sedation, respiratory depression and coma and can be dangerous.
  • It should not be mixed with blood thinners, such as aspirin, NSAIDs, heparin, warfarin, and other anti-coagulants. This might lead to bruising, nose bleeds, or internal bleeding.
  • This medicine should not be used along with or within two weeks of using Monoamine oxidase inhibitors (MAOIs) like Selegiline, Rasagiline, etc. It might cause serotonin syndrome, which is potentially ...
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  • It should not be used with medicines that also cause abnormal heart rhythms.
  • It should not be used with certain medications that affect the activities of the enzymes involved in metabolising the components of this medicine, as it can cause increased side effects.
  • It should not be taken with Tamoxifen as it decreases the effect of the latter medicine used in treating breast cancer.
  • This medicine should not be given in combination with Pravastatin, which manages high cholesterol levels. Their concomitant use can increase blood sugar levels and poor glycaemic control in people wit...
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Interactions with food items

  • This medication does not interact with food items.

Storage and disposal of Paro Cr Plus Tablets

Store Paro CR in a cool and dry place away from direct light and moisture. Do not use the medicine after the date of expiration. Keep the tablets away from children and pets. Don’t flush Paro CR down ...
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Dosage of Paro Cr Plus Tablets


Symptoms of overdose may include: Fainting, Somnolence, dizziness, poor coordination, muscle weakness, loss of balance, Low blood pressure (hypotension), Shallow breathing (hypoventilation), Coma, De...
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Missed a Dose

If you miss a dose of Paro CR, take it as soon as possible. If it’s almost time for the next dosage, it’s recommended to skip the missed dose and return to the regular schedule. Don’t double the dose ...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: I feel drowsy while I am on Paro CR. Can I stop taking it?

A: Abrupt stoppage of Paro CR can cause withdrawal symptoms which can be serious and debilitating. Consult your doctor for solutions and a safe manner to stop this medication if required.

Q: I have been using Paro CR for a few days but feel no change. What should I do?

A: Paro CR can take 3 to 4 weeks for maximum efficacy. Take this medication as directed by your treating physician. It is essential to review routinely for appropriate dose adjustment. Talk to your doctor for more information.

Q: I use Paro CR regularly, but I still feel depressed and anxious. Can I increase the frequency of this medication?

A: Paro CR has habit forming tendencies. Don’t increase the dose or frequency of this medication unless prescribed by your doctor. Regular follow-up while on this medication is important.
Product Details
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Last Updated on: 21 Mar 2022 | 05:56 PM (IST)
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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