Neukine 300mcg Solution For Injection

• Cancer Patients Receiving Myelosuppressive Chemotherapy
• Acute Myeloid Leukemia Receiving Induction Or Consolidation Chemotherapy
• Cancer Patients Receiving Bone Marrow Transplant
• Patients Undergoing Peripheral Blood Progenitor Cell Collection And Therapy
• Patients With Severe Chronic Neutropenia
• Patients Acutely Exposed To Myelosuppressive Doses Of Radiation (Hematopoietic Syndrome Of Acute Radiation Syndrome)
• Patients with neutropenia associated with advanced HIV infection, where indicated

• If you have a known severe hypersensitivity or allergy to filgrastim, E. coli-derived proteins, or any formulation component.
• If you have severe chronic neutropenia with evidence of leukemic transformation or myelodysplastic changes.
• If you have hereditary fructose intolerance (as some formulations contain sorbitol as an excipient).
• During pregnancy, use only when clearly necessary and after discussion with your doctor.

• Musculoskeletal pain (bone, joint, and muscle pain)
• Transient elevation of blood uric acid, lactate dehydrogenase (LDH), and alkaline phosphatase
• Nausea, vomiting, and loss of appetite
• Headache
• Splenomegaly (enlarged spleen), particularly in patients with severe chronic neutropenia
• Thrombocytopenia (low platelet count) and anemia
• Epistaxis (nosebleeds)may occur, particularly during prolonged treatment

• Diarrhea or constipation
• Fatigue, generalized physical weakness, and fever
• Alopecia (hair thinning/loss) and skin rash
• Injection site pain, redness, or swelling
• Mucositis (inflammation of the mouth or throat)

• Splenic Enlargement or Rupture: Sudden severe pain in the left upper abdomen or tip of the left shoulder (can be life-threatening).
• Acute Respiratory Distress Syndrome (ARDS): Sudden onset of shortness of breath, fever, and breathing difficulty or lung infiltrates.
• Severe Allergic Reactions / Anaphylaxis: Facial swelling, hives, difficulty breathing, or severe dizziness due to low blood pressure.
• Sickle Cell Crisis: Severe pain crisis in patients with underlying sickle cell disorders.
• Cutaneous Vasculitis / Sweet's Syndrome: Tender reddish skin lesions accompanied by fever or other signs of inflammation.

Other General Warnings

• You develop a sudden cough, fever, or difficulty breathing.
• You have a history of sickle cell disease or other blood disorders.
• You have pre-existing bone disease or osteoporosis, particularly if long-term treatment is planned.
• You notice unusual skin lesions, swelling, or signs of an allergic reaction.

• Neukine solution for injection is administered as a subcutaneous injection (under the skin) or as an intravenous (IV) infusion by or under the supervision of a healthcare professional.
• The exact dosage and duration of treatment depend on your body weight, the underlying condition being treated, and your blood cell count response.
• Follow all appointment schedules provided by your clinic or hospital for administration and blood monitoring.

• Store in a refrigerator. Do not freeze.
• Protect vials or pre-filled syringes from light by keeping them in the original outer carton.
• Dispose of clinical and hazardous waste (syringes, needles, vials) in designated sharp biohazard containers.

• Report any sudden pain in your upper left stomach or left shoulder to your doctor right away, as this can be a sign of an enlarged or ruptured spleen.
• Bone and muscle pain is the common side effect and can usually be managed with standard pain relievers (like paracetamol) as advised by your oncologist.
• Keep all scheduled appointments for complete blood count (CBC) monitoring.

Missed a Dose

Overdose

• An overdose may cause excessive elevation of white blood cells (leukocytosis) and musculoskeletal pain.
• If an overdose occurs,your doctor will monitor your blood counts and provide appropriate supportive treatment.

Interactions with other drugs

Interactions with food items