Gammaven 5000 Mg Infusion 100 Ml
100ml Injection in BottleMRP ₹14900.00
₹13010.00
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Made by
INTAS PHARMACEUTICALS LTD
Dosage
INJECTION
Expiry
Product Summary
| Uses | Primary immunodeficiency syndromes, Secondary immunodeficiency syndromes, Kawasaki syndrome, Idiopathic thrombocytopenic purpura (ITP), Paediatric HIV-1 infection, Allogeneic bone marrow transplantation, Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy (CIDP), Multifocal motor neuropathy (MMN) |
| Therapy | Immunomodulator |
| Side effects | Headache, Nausea, Chills, Fatigue, Fever, Upper abdominal pain, Diarrhoea, Back pain, Excessive sweating, Flushing |
| Salt Content | Immunoglobulin(5.0 %) |
Assurance
available
Regulated
Medical Description
Gammaven Injection is a highly purified preparation of human Immunoglobulin G (IgG), made from large pools of plasma collected from healthy human donors and treated with a solvent-detergent process. It provides passive immunity by increasing a person's antibody levels, and is used to prevent or treat certain infectious and immune-related conditions.
Gammaven Injection is used as replacement therapy in primary and secondary immunodeficiency syndromes, to treat idiopathic thrombocytopenic purpura (ITP), Kawasaki syndrome, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN), to reduce serious bacterial infections in children with HIV-related hypogammaglobulinaemia, and to reduce infections and graft-versus-host disease in people undergoing bone marrow transplantation.
It works by supplying a broad range of IgG antibodies collected from many plasma donors, reflecting the antibody activity found across that donor population. These antibodies increase a person's overall antibody level and their capacity to react with foreign antigens, which helps prevent or modify certain infections in people whose own antibody levels are too low, or who have conditions where immune modulation is helpful.
Gammaven Injection is given by a trained healthcare provider as a slow intravenous (IV) infusion, in a hospital or specialist healthcare setting, as recommended by your doctor.
Gammaven Injection may cause side effects like headache, nausea, chills, fatigue, fever, upper abdominal pain, diarrhoea, back pain, excessive sweating and flushing. It can also affect the kidneys, increase the risk of blood clots and, in a few cases, cause destruction of red blood cells (haemolysis), a rare brain inflammation called aseptic meningitis, and lung problems.
Warning signs that need to be reported to your doctor and require urgent medical attention include reduced urination, unexplained weight gain, fluid retention or shortness of breath (possible kidney problem); chest pain, sudden weakness on one side of the body, leg swelling or pain, or shortness of breath (signs of a blood clot); severe headache, neck stiffness, drowsiness, fever and sensitivity to light (signs of possible aseptic meningitis); a fast heartbeat, swelling, difficulty breathing, yellowing of the skin or eyes, or dark urine (possible haemolysis); and hives, tightness in the chest, dizziness, or a sudden drop or rise in blood pressure during the infusion (possible severe allergic or infusion reaction).
Before starting Gammaven Injection, have your doctor review your complete medical history, including any allergy, IgA deficiency, kidney problems, diabetes, a history of blood clots, high blood pressure, heart or cerebrovascular disease, and pregnancy status.
Uses
- Gammaven Injection is indicated for the management of:
- Replacement therapy in primary immunodeficiency syndromes.
- Replacement therapy in secondary immunodeficiency syndromes, such as B-cell chronic lymphocytic leukaemia or multiple myeloma with recurrent infections.
- Kawasaki syndrome.
- Idiopathic thrombocytopenic purpura (ITP).
- Paediatric HIV-1 infection with recurrent bacterial infections.
- Allogeneic bone marrow transplantation, for the treatment of infection and the prophylaxis of graft-versus-host disease.
- Allogeneic bone marrow transplantation, for persistent lack of antibody production.
- Guillain-Barre syndrome.
- Chronic inflammatory demyelinating polyneuropathy (CIDP).
- Multifocal motor neuropathy (MMN).
Contraindications
- If you have a history of anaphylaxis or a severe systemic reaction to immunoglobulin or to any of the ingredients in this medicine.
- If you have selective IgA deficiency, or IgA deficiency with antibodies against IgA.
Side effects
- Headache
- Nausea
- Vomiting
- Diarrhoea
- Upper abdominal pain
- Chills
- Fatigue
- Fever
- Back pain
- Pain in an arm or leg
- Joint pain
- Muscle pain
- Excessive sweating
- Flushing or hot flushes
- Dizziness
- Rash
- Itching
- Hives
- Cough
- Shortness of breath
- Fast heartbeat
- Palpitations
- Chest pain
- Raised liver enzymes
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have kidney disease or diabetes, or are dehydrated, as these increase the risk of kidney problems.
- You have a personal history of blood clots, high blood pressure, cerebrovascular or coronary artery disease, a clotting disorder or prolonged immobility, or you are overweight, as these increase the risk of thrombosis.
- You have cryoglobulins, very high triglycerides or a monoclonal gammopathy, which can increase the thickness of the blood.
- You have IgA deficiency, as you may be at greater risk of a severe allergic reaction.
- You are 65 years of age or older, as you may be at increased risk of blood clots and acute kidney failure.
- You have a history of migraine, as this may increase the likelihood of aseptic meningitis with this type of medicine.
Directions for Use
- Gammaven Injection is for intravenous use only and is given by a healthcare professional.
- Never attempt to change, delay, skip or repeat a dose on your own.
- Gammaven Injection must not be mixed with any other medicine or given through the same infusion line as other medicines, and must not be mixed with immunoglobulin products from other manufacturers.
Storage and disposal
- Gammaven Injection is a hospital-administered medicine, so the pharmacy normally handles its storage, preparation and disposal.
- Store it between 2 degrees C and 8 degrees C in its original container, protected from light. Do not freeze.
Quick Tips
- Report decreased urination, weight gain, fluid retention or shortness of breath to your doctor right away, as these may be signs of a kidney problem.
- Chest pain, sudden weakness on one side of the body, leg swelling or pain, or shortness of breath may signal a blood clot and need immediate medical attention.
- Report a severe headache with neck stiffness and fever, a fast heartbeat, swelling, yellowing of the skin or eyes, or dark urine to your doctor without delay.
- Inform your healthcare team immediately if you develop severe breathing difficulty, dizziness or fever, particularly within a few hours of your infusion.
- Tell your doctor about your vaccination history, since live vaccines are usually delayed for three months or more after treatment.
Dosage
Overdose
Overdose may lead to fluid overload and increased thickness of the blood (hyperviscosity). People at particular risk of these complications include elderly patients and those with kidney or heart impairment. Because Gammaven Injection is always administered and monitored in a healthcare setting by trained staff, the chance of overdose is very low.
Missed a Dose
If you miss a planned infusion or need to reschedule it, contact your doctor as soon as possible.
Interactions
Interactions with other medicines
- Gammaven Injection must not be mixed with other medicines or given through the same infusion line as other intravenous preparations, and must not be mixed with immunoglobulin products from other manufacturers.
- Antibodies in Gammaven Injection may interfere with the response to live virus vaccines, including measles, mumps and rubella (MMR) and varicella vaccines. Live vaccinations are generally delayed for three or more months after Gammaven Injection; for the measles vaccine this effect may last up to a year, so your doctor may check your antibody status.
- Antibodies transferred through Gammaven Injection can interfere with the results of certain blood (serological) tests.
- Tell your doctor about all prescription medicines, over-the-counter medicines, supplements and herbal products you are taking before and during treatment with Gammaven Injection.
Frequently Asked Questions (FAQs)
References:
- Intas Pharmaceuticals Ltd. GLOBUCEL (Human Normal Immunoglobulin for Intravenous Use IP), 10%. Ahmedabad: Intas Pharmaceuticals Ltd.
- Central Drugs Standard Control Organisation (CDSCO). Drugs@CDSCO. New Delhi: Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India.
- U.S. Food and Drug Administration (FDA). PRIVIGEN, Immune Globulin Intravenous (Human), 10% Liquid: prescribing information, revised 4/2025. Silver Spring (MD): U.S. Food and Drug Administration.
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Vendor Details
Fulfillment Information: Gammaven 5 % Injection (100) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
In Case of Any Issues Contact Us
Email Id:care@pharmeasy.in
Phone Number:7666100300
Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
