Domadol 50mg Injection 1ml

• As per CDSCO, Domadol is used in:
• Treatment of severe acute and chronic pain
• Management of procedural and post-surgical pain

• Domadol injection should not be administered or be given with caution:
• If you are hypersensitive to any of the components of this injection.
• If you have a known or suspected intestinal obstruction, including paralytic ileus.
• If you use this medication concomitantly with alcohol; this can be life-threatening and result in respiratory depression, coma and even death.
• If you have any seizure disorders, especially those not adequately controlled with medications; Domadol is contraindicated in such cases.
• If you are under 12; this injection is contraindicated in children.
• If you are under 18 and have undergone tonsillectomy and/or adenoidectomy; this injection is contraindicated in post-operative management.
• If you have severe/acute bronchial asthma in an unmonitored setting or the absence of resuscitative equipment.
• If you have significant respiratory depression.
• If you have severe liver or kidney disease.
• If you are in labour; this injection is not meant for use during childbirth.
• If you have a head injury; this injection is not meant for pain relief in such cases.

• Domadol injection can cause side effects such as:
• Nausea
• Dizziness
• Constipation
• Vomiting
• Confusion
• Dry mouth
• Sleepiness (somnolence)

Other General Warnings

• You take other medications for your existing conditions; tramadol in this injection interacts with many other medications that use the same metabolic enzymes.
• You have liver or kidney issues.
• You have a history of substance use/misuse.

• Domadol injection should be used as directed by your treating physician.
• It should be strictly administered by a trained healthcare professional, like a doctor or a nurse.
• Do not self-administer this medication.
• This medication should not be administered outside of a healthcare facility setting.
• Do not use it if the solution is unclear or has any suspended matter.

Overdose

Missed a Dose

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Interactions with other medicines

• Concurrent use of monoamine oxidase inhibitors (MAOIs) like selegiline and rasagiline or their use within the last 14 days is contraindicated.
• This medicine can cause serotonin syndrome when used with other medicines that increase the level of serotonin in the brain; this condition is potentially life-threatening. Serotonergic medicines include antidepressants like sertraline, escitalopram, fluoxetine etc.
• It should not be used with other medications that are known to decrease the seizure threshold.
• This injection should not be used with medications like warfarin that prevent blood clotting.
• Domadol injection should not be mixed with benzodiazepines or other CNS depressants, including alcohol, as it may result in profound sedation, respiratory depression, coma, and even death.
• Always inform your doctor about your medications to prevent unwanted interactions.