Distamin 250mg Capsules
Description
Distamin capsule contains penicillamine, which is a chelating agent used to remove excess copper from the body. It is mainly used in the treatment of Wilson’s disease, a genetic condition in which copper accumulates in organs like the liver and brain and causes damage.
This medicine is also used to reduce cystine levels in the urine in patients with cystinuria. Cystinuria is a hereditary condition that causes kidney stones due to excessive cystine accumulation.
Distamin capsule may also be used in patients with severe, active rheumatoid arthritis who have not responded adequately to other conventional treatments. It helps reduce disease activity and improves symptoms such as joint pain and swelling.
It is a prescription medicine that must be used under strict medical supervision because it may cause serious side effects. Regular monitoring and follow-up are necessary during treatment.
Product Summary
| Offer Price | ₹108.04 |
| You Save | ₹39.96 (27% on MRP) |
| Contains | Penicillamine(250.0 Mg) |
| Uses | Wilson’s disease |
| Side effects | Loss of appetite, nausea |
| Therapy | DRUGS FOR RHEUMATOID ARTHRITIS |
Uses
- Wilson’s disease
- Cystinuria (to reduce cystine kidney stone formation)
- Severe active rheumatoid arthritis when other treatments fail
Contraindications
- If you are pregnant (except in Wilson’s disease when advised by doctor)
- If you are breastfeeding
- If you have a history of aplastic anemia due to penicillamine
- If you have a history of agranulocytosis due to penicillamine
- If you have kidney problems and are being treated for rheumatoid arthritis
Side effects
- Loss of appetite
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Skin rash
- Loss of taste
- Mouth ulcers
- Low blood cell counts
- Kidney problems
- Liver problems
- Fever
- Hair loss
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You develop fever, sore throat, or infections
- You notice unusual bleeding or bruising
- You develop skin rash
- You develop kidney problems
- You develop liver problems
- You experience breathing problems
- You develop muscle weakness
- You are planning surgery
- You are planning pregnancy
Directions for Use
- Take Distamin capsule exactly as prescribed by your doctor
- Take it on an empty stomach
- Take it at least 1 hour before meals or 2 hours after meals
- Take it at least 1 hour apart from food, milk, antacids, iron, zinc, or other medicines
- Swallow the capsule with water
- Do not stop taking this medicine without consulting your doctor
Quick Tips
- Take Distamin capsule on an empty stomach to help your body absorb the medicine properly.
- Take the medicine regularly at the same time each day to get the maximum benefit.
- Do not skip doses, as missing doses may reduce the effectiveness of the treatment.
- Avoid taking Distamin capsule with food or milk, as this can reduce how well the medicine works.
- Get regular blood and urine tests as advised by your doctor to monitor your response and detect any side effects early.
- Inform your doctor immediately if you develop fever, skin rash, weakness, or any unusual symptoms.
- Do not stop taking Distamin capsule without consulting your doctor, even if you start feeling better.
- Keep regular follow-up appointments so your doctor can monitor your progress and adjust treatment if needed.
Storage and disposal
- Store Distamin capsule in a cool, dry place, protected from direct sunlight, moisture, and heat.
- Keep it out of the reach of children and pets.
Dosage
Missed a Dose
Overdose
Mode of Action
How Does It Work?
- Distamin capsule works by:
- Binding to excess copper and removing it from the body in urine
- Reducing cystine levels in urine and preventing kidney stones
- Suppressing disease activity in rheumatoid arthritis
- Preventing tissue damage caused by copper accumulation
Interactions
Interactions with other medicines
- Iron supplements may reduce the effectiveness of Distamin capsule by decreasing its absorption in the body, which can lower its therapeutic benefit.
- Zinc supplements can interfere with the absorption of Distamin capsule, making the medicine less effective.
- Antacids may reduce the absorption of Distamin capsule when taken at the same time, which can decrease its action.
- Gold therapy, when used along with Distamin capsule, may increase the risk of toxicity and side effects, so careful monitoring is required.
- Antimalarial medicines may increase the risk of side effects when taken together with Distamin capsule.
- Cytotoxic medicines used for cancer treatment may increase the risk of serious adverse effects when combined with Distamin capsule.
Interactions with food items
- Taking Distamin capsule with food may reduce its absorption and make the medicine less effective.
- Milk and dairy products may decrease the effectiveness of Distamin capsule by interfering with its absorption.
- Mineral supplements such as iron, calcium, magnesium, or zinc may reduce the absorption and effectiveness of Distamin capsule.
- Taking Distamin capsule on an empty stomach helps improve its absorption and ensures better effectiveness.
Content Details
Ravindra Ghongade
B. Pharm
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: Can I take Distamin capsule with milk or food?
Q: How should I take Distamin capsule for best results?
Q: Are regular tests needed while taking Distamin capsule?
References
- Merck & Co., Inc. Cuprimine® (penicillamine) capsules: Prescribing information [Internet]. Whitehouse Station (NJ): Merck & Co., Inc.; [cited 2026 Feb 16].
- Central Drugs Standard Control Organisation (CDSCO). Drugs@CDSCO [Internet]. New Delhi (India): Ministry of Health and Family Welfare, Government of India; [cited 2026 Feb 16].
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