Penicillamine

Uses	Wilson's Disease
Therapy	Drugs For Rheumatoid Arthritis
Side Effects	Loss of Appetite, Nausea

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Molecule Description

Penicillamine is ‘Disease Modifying Anti Rheumatic Drug (DMARD)’ primarily used for the treatment of Wilson’s disease (a rare genetic disorder which causes copper accumulation in the body) and Rheumatoid Arthritis.

Uses

Wilson’s disease
In severe rheumatoid arthritis that has not responded to other treatment
In cystinuria (excess of an amino acid called cystine in the urine which causes kidney stones)
Lead metal poisoning
Liver disease called chronic active hepatitis in adults

Contraindications

When should one not use Penicillamine

Do not take this medicine if you have an allergy to this medicine
After taking this medicine your white blood cells, platelets and red blood cells count decreases
You have systemic lupus erythematosus, a disease in which the body attacks its healthy tissue
You have kidney disease

Side effects

Common side effects of this drug are:

Bleeding through nose, gums, etc.
Skin bruise
Appearance of protein in urine

Precautions and Warnings

Pregnancy

It is probably considered unsafe to use this medicine during pregnancy, as it can cause adverse effects on unborn babies. Consult your doctor before taking this medicine.

Breast Feeding

This medicine can pass into breast milk and can cause adverse effects on the breastfed baby, therefore avoid this medicine in breastfeeding. Consult your doctor for advice.

Driving

Using this medicine usually does not usually affect your ability to drive.

Alcohol

No study found about an interaction of this medicine with alcohol.

Other General Warnings

Talk to your doctor if

You have allergy with gold or medicines containing gold
Your urine contains protein or blood
You have low white blood cell count
Your age is more than 60 years

Mode of Action

How Does It Work?

This medicine reduces the unusual response of the body's immune system in Rheumatoid Arthritis. It also acts by binding to accumulated copper and lead and its elimination through the body.

Interactions

Interactions with other medicines

Gold, Ibuprofen, Naproxen, Clozapine increase the side effects of this medicine when taken together
Iron medicine, antacids, zinc can change the effectiveness of this medicine
Digoxin

Interactions with food items

No specific interactions with food have been reported yet.

Dosage

Overdose

Consult your doctor as soon as possible if you consume more medicine than your usual dosing.

Missed a Dose

Take the missed dose as early as you remember. If the time for next dose is near, skip the missed dose and do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

You should not use this medicine if you are allergic to it, if you have kidney disease, liver disease, a history of stomach ulcers, a weak immune system or if you are malnourished.

Consult your doctor if there is severe joint and muscle pain when you are on treatment with this medicine.

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