Ulinastatin

Uses	Severe sepsis, acute pancreatitis
Therapy	Drugs For Acute Pancreatitis, Drugs For Sepsis
Side Effects	Injection site reaction

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Molecule Description

Ulinastatin is used to treat severe sepsis caused due to varied reasons as well as acute pancreatitis. It acts by inhibiting the action of inflammatory marker substances. This medicine should be diluted with a suitable solution such as dextrose or normal saline before administering. It will be administered at the hospital only under the medical supervision of a physician.

Uses

Ulinastatin is used for the treatment of severe sepsis, acute pancreatitis (inflammation of the pancreas).

Contraindications

When should one not use Ulinastatin

If you are allergic to ulinastatin or any other ingredient of Ulinastatin.

Side effects

Common side effects of this drug are:

Injection site reaction.

Precautions and Warnings

Pregnancy

There is limited data available about the effect of Ulinastatin on pregnancy. Your doctor will decide the necessity of this medicine based on your condition. Talk to your doctor for more information.

Breast Feeding

Ulinastatin should not be used by breastfeeding mothers. If you are on this medicine, you should stop breastfeeding. Talk to your doctor for more information.

Driving

Ulinastatin is unlikely to affect the ability to drive.

Alcohol

There is limited data available about the interaction of Ulinastatin and alcohol. Alcohol may delay the healing process. Talk to your doctor for more information.

Other General Warnings

Talk to your doctor if

You experience allergic reactions to this medicine.
You are hypertensive.
You are a nursing mother.
Ulinastatin is not to be used in children below 18 years of age.

Mode of Action

How Does It Work?

Ulinastatin acts by inhibiting the release of inflammatory substances such as trypsin, pancreatic elastase, polymorphonuclear leukocyte elastase and the endotoxin-stimulated production of TNF alpha and interleukin 1, 8 and 6. This further aids in improving the condition.
It also inhibits fibrosis, coagulation and activates microperfusion. Thus, prevents organ damage.

Interactions

Interactions with other medicines

Some medicines can affect the way Ulinastatin works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.

Dosage

Overdose

This medicine will be given by a doctor or nurse thus chances of overdose are unlikely. However, if you experience any discomfort or specific symptoms, inform your doctor or reach out to the nearest hospital.

Missed a Dose

It is unlikely that the dose of this medicine will be missed if you are monitored in a healthcare setup. However, if you have missed any dose of this medicine, inform your doctor or nurse immediately.

Frequently Asked Questions (FAQs)

Ulinastatin is usually given via intravenous route via infusion over 1 hour. This medicine is diluted with suitable solutions such as dextrose or in normal saline.

Ulinastatin is given by a doctor at a dose and for a duration suited to your condition. Discuss any concerns about its safety with your doctor.

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Ulinastatin

Molecule Summary