Trioxsalen

Uses	Psoriasis and vitiligo
Therapy	Anti-Vitiligo, Drugs For Psoriasis
Side Effects	Itching, nausea, vomiting, headaches, tiredness, dizziness, fever

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Molecule Description

Trioxsalen is primarily used to treat certain skin conditions, including vitiligo and psoriasis. It is a photosensitive medication used along with UV-A rays therapy. Psoriasis is a skin disease that causes red, itchy scaly patches commonly on the knees, elbows, and scalp. And vitiligo is a disease in which skin colour is lost. Trioxsalen belongs to a class of medicines called photosensitizers.

Uses

Trioxsalen is used to treat vitiligo, a condition in which the skin loses its pigment cells (melanocytes).

Contraindications

When should one not use Trioxsalen

If you are allergic to trioxsalen or any other ingredient of Trioxsalen.

Side effects

Common side effects of this drug are:

Headaches
Itching
Nausea
Vomiting
Tiredness
Dizziness
Fever

Precautions and Warnings

Pregnancy

There is limited information on the use of Trioxsalen in pregnancy. Hence it is recommended not to use this medicine unless prescribed by your doctor.

Breast Feeding

A breastfeeding mother should take this medicine only under a doctor's recommendation. Refrain from self-medication.

Driving

Sometimes this medicine may cause dizziness, as a side effect. So, it is advised to avoid driving or operating any heavy machinery until you know how Trioxsalen affects you.

Alcohol

There is no known interaction between alcohol and Trioxsalen. However, consult your physician if you drink too often.

Other General Warnings

Talk to your doctor if

You experience burning, blistering, or skin irritation after taking this medicine.
You are pregnant or breastfeeding.
You have any other medical condition such as eye problem, stomach problem or heart disorder etc.
You have a history of skin cancer.
You are already taking any other medications including vitamins or supplements as well.
Control exposure to direct sunlight as per the doctor's instructions.
If sunlight cannot be avoided, use sunblock (consult prescriber for specific SPF level), and wear protective clothing.

Mode of Action

How Does It Work?

Trioxsalen is a photosensitive medication used along with UV-A rays (ultraviolet light A). It penetrates the skin and increases skin melanization (form melanin). It activates certain skin cells (melanocytes) and helps repigment the discoloured, white patches.

Interactions

Interactions with other medicines

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Trioxsalen may affect the way other medicines work, and other medicines may affect how Trioxsalen works.
In particular, if you are taking any other skin treatment or any medication for your skin condition.

Dosage

Overdose

There is limited information about the effect of an overdose of Trioxsalen. In case of an overdose, contact your doctor or reach out to your nearest hospital as soon as possible. Try to carry the pack of the medicine to make overdose assessment easier for doctor/hospital staff.

Missed a Dose

It would be best if you don't miss a dose of Trioxsalen as it may lead to treatment failure.
If you have missed taking any dose of this medicine, take it as soon as you remember.
If it's already the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Never take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

Yes, dizziness can be experienced as a side effect in a few individuals. So it is advised to avoid driving or doing any physical activity that requires mental alertness, during the treatment with Trioxsalen.

The dose and duration of Trioxsalen usually depend on the severity of the condition, as well as the patient's medical history and current health condition. Do not exceed the maximum daily doses and treatment durations recommended.

You should take Trioxsalen exactly as told by the doctor. However, it should preferably be taken with milk or after meals to avoid stomach irritation or discomfort.

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Trioxsalen

Molecule Summary