Tofacitinib

Uses	Rheumatoid arthritis
Therapy	Drugs For Rheumatoid Arthritis
Side Effects	Headache, nausea, diarrhoea, increase in blood pressure, infection and inflammation of the nose and throat

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Molecule Description

Tofacitinib is a medication used to treat rheumatoid arthritis, an inflammatory disease that mainly causes pain and swelling in the joints. By reducing the discomfort, pain, and swelling of your joints, Tofacitinib improves your ability to perform daily tasks. It is important to take this medicine in the same dose and duration as recommended by your doctor. For maximum benefits, take it at the same time every day. If you have a severe infection, or liver problems, are allergic to tofacitinib, or are pregnant or breastfeeding, it is important to inform your doctor. Do not stop taking this medicine even if you start feeling better without consulting your doctor.

Uses

Tofacitinib is used for the treatment of rheumatoid arthritis in adults.

Contraindications

When should one not use Tofacitinib

If you are allergic to tofacitinib or any other ingredient of Tofacitinib.
If you have tuberculosis (TB), serious infections such as sepsis, or opportunistic infections (infections that occur more frequently and more severely in people with a weak immune system).
If you have any kind of liver disease.
If you are pregnant, planning to become pregnant, or breastfeeding.

Side effects

Common side effects of this drug are:

Headache
Nausea
Diarrhoea
Cough
Increase in blood pressure
Infection and inflammation of the nose and throat

Precautions and Warnings

Pregnancy

Limited information is available regarding the safety of Tofacitinib in pregnant women. As a precautionary measure, the use of Tofacitinib during pregnancy is contraindicated. Women of childbearing potential (women before menopause who are capable of becoming pregnant) should use effective contraceptive measures while on treatment with Tofacitinib.

Breast Feeding

There is limited information available regarding the excretion of Tofacitinib in human breastmilk. Thus, it is advised to avoid taking this medicine to prevent any risks to the breastfed child.

Driving

Tofacitinib has no influence on the ability to drive. However, if you feel that you may not be able to drive safely after taking Tofacitinib, it is suggested that you do not drive.

Alcohol

There is limited information available regarding the interaction of alcohol with Tofacitinib. Ask your doctor for advice on alcohol intake along with Tofacitinib.

Other General Warnings

Talk to your doctor if

You think you have an infection or have symptoms of an infection such as fever, sweating, chills, muscle pain, cough, difficulty breathing, weight loss, warm or red or painful skin or sores on your body, difficulty or pain when swallowing, diarrhoea, stomach pain, burning when you urinate or urinating more often than normal, feeling very tired.
You already are taking medicines for any kind of infection or have infections that keep coming back.
You have any condition that increases your chance of infection (diabetes, weak immune system).
You have or have a history of tuberculosis or have been in close contact with someone with tuberculosis.
You have any kind of lung disease, liver disease, kidney disease, or heart disease (high blood pressure, high cholesterol).
You have or had hepatitis B or hepatitis C (viruses that affect the liver).
You are older than 65 years.
You currently smoke or used to smoke in the past.
You have any type of cancer.
You have had diverticulitis (a type of inflammation of the large intestine) or ulcers in the stomach or intestines.
You are planning to get vaccinated soon.

Mode of Action

How Does It Work?

Tofacitinib works by blocking the action of a certain chemical in the body known as Janus kinase. This chemical plays an important role in the process of inflammation in rheumatoid arthritis. By blocking the action of this chemical, Tofacitinib helps to reduce inflammation, pain, and discomfort that occurs in rheumatoid arthritis.

Interactions

Interactions with other medicines

Some medicines can affect the way Tofacitinib works, or Tofacitinib itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
Tofacitinib when given along with ketoconazole, itraconazole, ritonavir, nefazodone, telithromycin increases the level of Tofacitinib in the body.
Tofacitinib when given along with rifampicin decreases the level of Tofacitinib in the body.
Care should be taken when Tofacitinib is administered along with medicines like fluconazole, tacrolimus, and cyclosporine.

Dosage

Overdose

Symptoms of overdose of Tofacitinib include headache, nausea, and diarrhoea. If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

You should never miss your dose of medicines. However, if you missed any dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

Frequently Asked Questions (FAQs)

Rheumatoid arthritis is an inflammatory disease where your immune system attacks your own body's tissues and causes swelling, pain, and discomfort in your joints. Rheumatoid arthritis is a long-term disease and the signs and symptoms of the disease include pain, swelling, & stiffness in one or more joints, weight loss, fever, tiredness, and weakness.

Tofacitinib starts working as soon as you start with the treatment. However, the improvement in your symptoms might take a few weeks depending on the severity of your condition and its physiology. Talk to your doctor for more information.

No, Tofacitinib does not have weight gain or weight loss as common side effect. However, if you think you are experiencing changes in weight, talk to your doctor.

No, hair loss was not reported as a side effect of taking Tofacitinib. If you have any concerns about hair loss while taking this medicine, talk with your doctor.

Both Tofacitinib and Humira are used for the treatment of rheumatoid arthritis. Tofacitinib is an oral medicine while Humira is an injection. Both Tofacitinib and Humira work in different ways to reduce the pain, swelling, and discomfort in the joints. Your doctor will suggest you the best possible medicine for your condition based on your signs and symptoms.

Tofacitinib is an anti-rheumatoid medicine that is used to reduce the signs and symptoms of rheumatoid arthritis. Tofacitinib reduces the inflammation of the joints that occurs because of rheumatoid arthritis.

Yes, Tofacitinib is an anti-inflammatory immunosuppressant medicine that reduces the activity of the immune system. This reduction in activity reduces the pain, swelling, and discomfort of the joints in rheumatoid arthritis.

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Tofacitinib

Molecule Summary