Temozolomide

Uses	Brain and spine cancer
Therapy	Anti-Neoplastic
Side Effects	Nausea, vomiting, hair loss, headache

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Molecule Description

Temozolomide is an anti-cancer medicine. It is used to treat and manage brain and spine cancer along with other therapies. It acts by killing cancer-causing cells, thereby preventing the spread of cancer. Take Temozolomide as advised by your doctor at prescribed dose and duration.

Uses

Temozolomide is used for the treatment and maintenance of brain and spine cancer along with other therapies.

Contraindications

When should one not use Temozolomide

If you are allergic to temozolomide, dacarbazine or any other ingredient of Temozolomide.
If you have bone marrow failure or decreased activity of bone marrow.

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Headache
Infections
Fatigue
Loss of appetite
Hair loss

Precautions and Warnings

Pregnancy

Temozolomide should not be used during pregnancy, as there is limited information about its effect on unborn baby. Your doctor will decide the necessity of the treatment with this medicine during pregnancy after assessing the risk and need.

Breast Feeding

Temozolomide should not be used while breastfeeding, due to limited information. Breastfeeding should be discontinued while on this medicine.

Driving

If you experience fatigue or sleepiness after taking Temozolomide, it is advised to avoid driving.

Alcohol

You should avoid consuming alcohol while on Temozolomide. Talk to your doctor if you consume it often.

Other General Warnings

Talk to your doctor if

You develop any infections while on Temozolomide.
You have viral infections such as herpes of the brain or hepatitis.
You develop pneumonia.
You have liver disease.
You have any other cancers.
You experience nausea and vomiting.
You are elderly.
Males should not plan to become a father for at least 3 months after the last dose, while females should refrain from planning pregnancy at least for 6 months.
Temozolomide should not be used in children below 3 years of age.

Mode of Action

How Does It Work?

The growth and multiplication of cells take place through DNA, a genetic material. Temozolomide works by inhibiting the growth and multiplication of cancer cells by stopping them from making DNA, resulting in cell death.

Interactions

Interactions with other medicines

Some medicines can affect the way Temozolomide works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
Especially if you are taking medicine to treat seizures.

Dosage

Overdose

If you have taken too much of Temozolomide, contact your doctor or reach out to the nearest hospital immediately.

Missed a Dose

If you have missed taking any dose of Temozolomide, take it as soon as you remember. If it's already time for the next dose, skip the missed dose and follow the regular dosing schedule.

Frequently Asked Questions (FAQs)

Do not stop taking Temozolomide until and unless your doctor advises you. If you stop taking this medicine, it can lead to an incomplete killing of cancer cells and thus increase the risk of the reoccurrence of cancer. The doctor will gradually decrease the dose as per the need.

No, you should not plan pregnancy for at least 3 months after the completion of the last dose with Temozolomide.

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Temozolomide

Molecule Summary