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Molecule Description

Silymarin is a standardized extract of milk thistle seeds (Silybum Marianum L.), containing a mixture of Flavonolignans. This medicine is a herbal supplement which causes detoxification and protection of liver function.
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Uses of Silymarin

For supportive treatment in chronic liver disease and cirrhosis.

Contraindications of Silymarin

When should one not use Silymarin

If you are allergic to Silymarin or any ingredient of this medicine.

Side effects of Silymarin

Common side effects of this drug are:

  • Nausea
  • Diarrhea
  • Intestinal gas
  • Fullness or pain in stomach
  • Loss of appetite
  • Rashes and itching

Precautions and Warnings of Silymarin


Can I take Silymarin during pregnancy?
You should not take this medicine during pregnancy. Limited information is available about its safety in pregnancy, hence do not take this medicine unless it is considered essential by a physician.

Breast Feeding

Can I take Silymarin while breastfeeding?
Take this medicine only when advised by your doctor.


Can I drive if I have consumed Silymarin?
Limited information is available about the effect of this medicine while driving.


Can I consume alcohol with Silymarin?
It is known to show interactions with alcohol and hence alcohol must be avoided.

Other General Warnings

Talk to your doctor if
  • You have high-risk factors include under-active thyroid or excessive use of alcohol or diabetes, breast cancer, uterine cancer, endometriosis, uterine fibroids
  • You should inform your doctor before surgery regarding all the products you use (including prescription medicines, nonprescription medicines and herbal products)

Mode of Action of Silymarin

How Does It Work?

This medicine protects liver cells from toxic chemicals and medicines by antioxidant and anti-inflammatory effects. It may also enhance the effects of estrogen.

Interactions of Silymarin

Interactions with other medicines

  • Amitriptyline
  • Diazepam
  • Zileuton
  • Fluvastatin
  • Celecoxib

Interactions with food items

No information is available on interactions of Silymarin when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Silymarin

No information is available on dietary restrictions while you are taking Silymarin, consult your doctor or pharmacist for further details.

Dosage of Silymarin


If you think you have taken an overdose of Silymarin, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you miss a dose, follow the regular dosing schedule. Do not double the dose.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

  • Tell your doctor if you have-
  • Allergy to this medicine
  • Breast cancer
  • Uterine cancer
  • Endometriosis
  • Uterine fibroids
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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