Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen

Uses	Cold, Stuffy nose, Painful sinuses
Therapy	Cough Cold Preparation
Side Effects	Nausea, Vomiting, Sleepiness, Constipation, Dizziness, Dryness in mouth, Weakness.

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Molecule Description

Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen is a medication used for relieving cold, cough and fever caused by an infection. It is a combination of pseudoephedrine, paracetamol, and triprolidine. Pseudoephedrine helps relieve stuffy nose and sinuses. Triprolidine is an anti-allergy medication that helps with runny nose and sneezing. Paracetamol is a painkiller and fever-reducing medicine.

Uses

As per CDSCO, Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen can be used for the management of cold and cough in people with the symptoms of upper respiratory tract infection (reduces stuffy nose, blocked sinuses, cough, sneezing, etc.)

Contraindications

When should one not use Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen

If you have an allergic reaction to any component of Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen.
If you have liver failure or other conditions that affect the liver's functioning. This is because the medicine increases the risk of adverse reactions.
If you have severe kidney-related disorders.
If you are suffering from breathing issues like asthma.
If you have stomach bleeding or perforation.
If your body has been in shock, with sufficient blood not pumped to all body parts.
Note - Do not give this to children without consulting a doctor.

Side effects

Common side effects of this drug are:

Nausea
Dizziness
Dryness of the mouth
Depression
Drowsiness
Headache
Constipation
Shortness of breath

Precautions and Warnings

Pregnancy

If you are pregnant, confirm with your doctor before taking Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen. There is limited information regarding the safety of this medicine in pregnant women and foetus development.

Breast Feeding

There is not sufficient data of Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen effects on breastfeeding babies and mothers. Consult your doctor for proper treatment, and try not to self prescribe.

Driving

Lornoxicam+Paracetamol / Acetaminophen contains pseudoephedrine (a nasal decongestant) and triprolidine (an antihistamine that can cause drowsiness). It can cause side effects like dizziness, drowsiness, and blurred vision. Therefore, do not drive or operate heavy machinery if you have taken this medication.

Alcohol

No, do not consume alcohol with Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen. It increases the effects of alcohol. It can also cause side effects like drowsiness, nausea, vomiting, unconsciousness, dizziness, etc.

Other General Warnings

Talk to your doctor if

You have any seizure disorder, consult your doctor first before taking Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen.
You have been diagnosed with active liver inflammation with Hepatitis C infection.
You have stomach conditions like bleeding, perforation, ulcers, etc.
You consume alcohol every day. Notify your doctor before taking Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen, as it can affect the functioning of the liver.
You suffer from malnutrition, use Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen with caution after informing your doctor.
You are taking any herbal or ayurvedic supplements.

Mode of Action

How Does It Work?

Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen consists of pseudoephedrine, paracetamol, and triprolidine as three main ingredients. Acetaminophen works as an analgesic (painkiller) and antipyretic (lowers fever). It helps decrease the production of chemical substances like prostaglandins (a natural substance in the body), responsible for pain and inflammation. It also regulates the body temperature by working on specific areas in the brain (hypothalamic heat-regulating centre).

Interactions

Interactions with other medicines

Do not take Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen with other medications like opioid pain relievers, as they can cause extreme drowsiness. It can also damage the liver.
Do not take Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen with MAO (monoamine oxidase) antidepressants like linezolid, methylene blue, etc. They can cause increased side effects like drowsiness, dizziness, tremors, lethargy, vomiting, etc.
Do not take it with antihistamines (anti-allergy medicine) like cetirizine and diphenhydramine, as they can also increase the effects of drowsiness.
Taking this medicine with other medications such as antifungal medicines, antiepileptic medicine (controls seizures), antivirals like HIV medicines can cause interactions and cause unwanted side effects or lower their effectiveness.

Dosage

Overdose

Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen overdose can cause abdominal pain, dizziness, fainting, vomiting, seizures, low blood sugar, sweating, cardiac arrest, lethargy, low blood pressure, liver failure (yellow skin and eyes), confusion, and coma. In case of overdose, seek immediate medical treatment from the nearest medical centre.

Missed a Dose

If you have missed a dose of Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen, you can take it when you remember it. But, skip the missed dose if it's already time for the next one. Do not take two doses at the same time, as this can lead to an overdose.

Frequently Asked Questions (FAQs)

Depending on its components, most cold and allergy medicines can cause drowsiness and slow breathing. These side effects can be increased when combined with Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen. Try not to take similar medications without consulting your doctor.

Try not to take other medication with paracetamol and similar ingredients while using Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen. It increases the risk of overdose, which can cause symptoms like dizziness, stomach bleeding, liver failure, kidney failure, stomach ulcers, etc.

Pseudoephedrine+Triprolidine+Paracetamol / Acetaminophen is only recommended as a short-term treatment for relieving cold and allergic symptoms. You can stop using it once the symptoms have subsided. However, if you have any concerns about when to stop, please consult your doctor.

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