Phenylephrine+Triprolidine

Uses	Common cold, allergic rhinitis
Therapy	Cough Cold Preparation
Side Effects	Irregular heart rate, mood swings, fits, weakness, drowsiness

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Molecule Description

Phenylephrine+Triprolidine is a combination medicine used for the treatment of symptoms associated with common cold and cold associated with allergies (allergic rhinitis or upper respiratory allergies). It contains two active ingredients phenylephrine which acts as a decongestant and triprolidine which belongs to the anti-allergic class of medicines. Phenylephrine+Triprolidine provides temporary relief to the symptoms like watery eyes, itching in the nose/eyes, stuffy nose, sneezing and nasal congestion. It is advised to take the exact recommended dose only and don't advise the same to others even if they have the same symptoms. If no improvement is seen within a week and you experience any kind of adverse reactions like rashes or fever, contact your doctor immediately. Discuss with your doctor about your medical history and any other medicines you are taking currently to avoid any possible adverse reactions.

Uses

Phenylephrine+Triprolidine is indicated for the temporary relief of symptoms associated with common cold and allergy associated cold. Symptoms may include nasal congestion, sneezing, a runny nose, itching in the nose and throat, watery eyes, swelling in the nasal passage, etc.

Contraindications

When should one not use Phenylephrine+Triprolidine

If you are allergic to this medicine or any of the ingredients of Phenylephrine+Triprolidine.
If you are already taking medicines used to treat brain disorders (MAO inhibitors), as there should be at least a gap of 2 weeks before starting this medicine.

Side effects

Common side effects of this drug are:

Irregular heart rate
Mood swings
Fits
Easy bleeding
Weakness
Decreased frequency of urination
Breathlessness
A rise in blood pressure
Headache
Blurred vision
Dizziness, drowsiness
Dry mouth
Upset stomach, constipation

Precautions and Warnings

Pregnancy

Phenylephrine+Triprolidine can be recommended during pregnancy only if your doctor considers it essential. Hence, consult your doctor before using this medicine if you are pregnant or are planning to get pregnant.

Breast Feeding

A breastfeeding mother should take Phenylephrine+Triprolidine only under a doctor's recommendation. Avoid self-medication.

Driving

It may cause blurred vision and impair your thinking. So avoid driving or using heavy machines when you are on treatment with this medicine.

Alcohol

Alcohol consumption along with this medicine should be avoided, as it can make you feel more dizzy and drowsy. So it is better to avoid alcoholic beverages during the treatment.

Other General Warnings

Talk to your doctor if

You have any kind of breathing problems.
You are suffering from a condition with increased pressure inside the eyes (glaucoma).
You have any other medical conditions like thyroid disease, heart-related problems, diabetes or high blood pressure.
You feel difficulty in passing urine due to enlarged prostate.
You are already taking medicines for a psychiatric disorder or to induce calmness. As it may cause more drowsiness and more excitement in children.
You don't feel any improvement within a week and feel fever or rashes.
It should not be given to children below 4 years of age.

Mode of Action

How Does It Work?

Phenylephrine acts as a decongestant. It helps in removing the congestion in the nose area by narrowing the blood vessels in the nasal passage.
Triprolidine is an anti-allergic medicine, that acts by blocking the action of histamine, a natural substance produced by the body during an allergic reaction.
Thus, the combined action of these two ingredients helps in controlling allergic symptoms such as a runny nose, watery eyes, sneezing, nasal congestion, etc.

Interactions

Interactions with other medicines

Anti-allergic medicines that are used topically like ointments, creams or sprays should be used cautiously during the treatment with Phenylephrine+Triprolidine.
Caution is recommended on the simultaneous use of Phenylephrine+Triprolidine and blood pressure-lowering medicines like atenolol, nifedipine etc.
Concomitant use with medicines that are used to improve brain disorders like selegiline, phenelzine, procarbazine etc. should be avoided. Also, it is suggested to keep a gap of at least 2 weeks before starting treatment with Phenylephrine+Triprolidine.
Other medicines that act on the brain and produce calmness like codeine, hydrocodone, alprazolam, zolpidem and other anti-allergic medicines like cetirizine, diphenhydramine etc., should be used with caution.
Discuss with your doctor about any other medicines, herbal preparations and supplements you are taking currently to avoid any possible drug interactions.

Dosage

Overdose

Symptoms of an overdose may include severe forms of some of the side effects including hallucination, fits and irregular heartbeats.
In case of an overdose, contact your doctor immediately if you experience any of such symptoms.

Missed a Dose

If you have missed taking any dose of this medicine, take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule.

Frequently Asked Questions (FAQs)

You should discuss about all the medicines you are currently taking and a detailed history of your medical condition. You should inform if you are currently taking or had taken in the last few days, any medicines that act on the brain like selegiline, phenelzine etc. Also if you are pregnant or a breastfeeding mother as it can affect the foetus and the suckling infant.

Yes, it can make drowsy. So be cautious and avoid driving after taking this medicine.

Take this medicine only for as long as your doctor advises. If you don't feel any improvement and feel persistent cough and nasal congestion accompanied by fever or headache, consult a doctor.

Yes, it can cause drowsiness, sleepiness, nervousness, irregular heartbeats, weight gain, etc. Phenylephrine+Triprolidine can cause addiction also if taken more than the recommended dose.

Phenylephrine+Triprolidine should not be given to children below 4 years of age. It is suggested not to give any kind of cold or cough medicines to the children without a doctor's consultation.

The composition of Phenylephrine+Triprolidine includes phenylephrine that acts as a decongestant and triprolidine that belongs to the anti-allergic class of medicines.

Phenylephrine+Triprolidine contains phenylephrine and triprolidine while Phenylephrine+Triprolidine plus contains paracetamol, pseudoephedrine and triprolidine, as its active components.

The dose and frequency of Phenylephrine+Triprolidine varies among individual depending on the condition it is being taken for. You should not consume more than the recommended daily dose by doctor.