Olaparib

Uses	Ovarian cancer, Breast cancer, Fallopian Tube Cancer
Therapy	Anti-Neoplastic
Side Effects	Anaemia, Loss of appetite, Dizziness, Headache, Cough, Fatigue, Vomiting, Diarrhoea, Nausea

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Molecule Description

Olaparib is an anti-cancer medicine. It works by disrupting a key repair mechanism in cancer cells, making it difficult for them to repair their damaged DNA and leading to their inability to grow and spread. This targeted approach helps in the treatment of certain types of cancer, particularly those with defects in DNA repair pathways. Women of childbearing potential should not be pregnant when starting treatment with Olaparib, and they should use effective contraception throughout the course of therapy and for 6 months after the last dose. Before initiating treatment, a pregnancy test is recommended for all women capable of becoming pregnant. These precautions are necessary to prevent unintended pregnancies and ensure the safety of both the woman and potential fetus, as Olaparib may pose risks to fetal development. Therefore, strict adherence to reliable contraception methods is crucial for women of childbearing potential receiving Olaparib.

Uses

Ovarian cancer
Breast cancer
Fallopian Tube Cancer

Contraindications

When should one not use Olaparib

Allergy to the active substance or any of the excipients of Olaparib
Pregnancy

Side effects

Common side effects of this drug are:

Anaemia
Loss of appetite
Dizziness
Headache
Dysgeusia (altered taste )
Cough
Fatigue
Vomiting
Diarrhoea
Nausea
Indigestion and heartburn
Low WBC and platelets

Precautions and Warnings

Pregnancy

Olaparib should not be used during pregnancy. Women of childbearing potential must use effective contraception during therapy and for 6 months after receiving the last dose of Olaparib.

Driving

Olaparib has a moderate influence on the ability to drive and use machines. Patients taking Olaparib should exercise caution when driving or operating machinery.

Alcohol

No information is available on interactions of Olaparib and alcohol.

Other General Warnings

Talk to your doctor if

You have liver or kidney problems.
You are taking any other medications or herbal supplements.
You are pregnant, become pregnant, or plan to become pregnant. Olaparib can harm an unborn baby and may cause loss of pregnancy (miscarriage).
You are breastfeeding or plan to breastfeed.
Females who can become pregnant should use effective birth control (contraception) during treatment with Olaparib and for 6 months after the last dose of Olaparib.
Males with female partners who are pregnant or able to become pregnant should use effective birth control (contraception) during treatment with Olaparib and for 3 months after the last dose.
Do not donate sperm during treatment and for 3 months after your last dose.
Do not breastfeed during treatment and for 1 month after receiving the last dose.

Mode of Action

How Does It Work?

Olaparib disrupts a key repair mechanism in cancer cells, making it difficult for them to repair their damaged DNA and leading to their inability to grow and spread. This targeted approach helps in the treatment of certain types of cancer, particularly those with defects in DNA repair pathways. This medicine is usually prescribed as adjunctive therapy in cancer treatment.

Interactions

Interactions with food items

Grapefruit or grapefruit juice should not be taken while on this medicine.

Dosage

Overdose

In the event of an overdose, report to your doctor immediately.

Missed a Dose

Report to your doctor immediately. Do not take extra doses to compensate for missed doses.

Frequently Asked Questions (FAQs)

Olaparib can lower your white blood cells, which help fight infections. Therefore, your body may take longer to recover, even from a mild infection. When on treatment for cancer, one should exercise extra care to reduce the risk of any kind of infection and stay as protected as possible.

No, nose bleeds are not normal. These may indicate low platelets, which need to be checked and managed promptly by doctors. Do not ignore signs like unexplained bleeds or bruises, and inform your doctor immediately.