Octreotide

Molecule Description

Octreotide is an artificially produced lon- acting somatostatin hormone whose m

ain function in the body is to block the actions of growth hormone. The function of growth hormone (or somatotropin) is to help in growth, cell regeneration and cell multiplication in our body, the actions of which are opposed by somatostatin.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Octreotide

Acromegaly (a condition in which growth hormone is produced in excess) Signs include big
hands, feet, face, large bones and disproportionate increase in height
Relief of symptoms in slow growing cancers (carcinoid tumors eg cancerous growths in the gut
–appendix, small intestine, colon)
To stop and prevent bleeding from dilated veins of the esophagus in severe liver disease
(gastroesophageal varices)
Cancer of Thyroid hormone secreting gland (pituitary adenomas) – cause increased thyroid
levels in the body

Contraindications of Octreotide

When should one not use Octreotide

Allergy to Octreotide or any of its components

Side effects of Octreotide

Common side effects of this drug are:

Sudden back pain (due to gall stones)
High blood sugar (hyperglycemia) or very low sugar (hypoglycemia) – poor control over
blood sugars
Decreased thyroid hormones (due to decreased activity of thyroid gland)
Irritation/inflammation of the gall bladder (cholecystitis)
Irregular heartbeats (slow or fast)
Feeling thirsty, low urine output, dark urine, dry and reddened skin
Allergic reactions (skin rashes, itching, swelling, breathing difficulty etc)
Irritation of the Pancreas (sudden pain in the stomach, vomiting, diarrhea)
Liver damage
Decreased platelet count

Precautions and Warnings of Octreotide

Pregnancy

Can I take Octreotide during pregnancy?

Available data suggests that Octreotide can harm your unborn baby and hence is advisable to avoid it during pregnancy

Breast Feeding

Can I take Octreotide while breastfeeding?

It is not known whether Octreotide is secreted into breast milk and is recommended to be avoided in females breastfeeding their babies

Driving

Can I drive if I have consumed Octreotide?

Octreotide has no direct effects on your driving ability But caution is advised. If you experience any symptoms such as dizziness, headache, fatigue

Alcohol

Can I consume alcohol with Octreotide?

Alcohol interacts with Octreotide and may worsen the side effects of this medicine. It is best to avoid alcohol while taking this medicine Occasional drinking may be permissible

Other General Warnings

Talk to your doctor if

If you suffering from or have a history of Gall stone disease
If you are a diabetic (octreotide can increase blood sugar levels)
If you have vitamin B12 deficiency
Caution is advised when using this in children Use of this medication for long periods (eg, longer
than 1 year) may slow a child's growth rate However, the growth rate catches up Octreotide is
stopped. Consult your doctor for more information

Mode of Action of Octreotide

How Does It Work?

Octereotide works by blocking the secretion of growth hormone in whom it is produced in
excess due to various conditions (hormonal disorders, tumors etc)
Both the growth hormone and somatostatin are naturally produced by the body Octreotide is an
artificial form of somatostatin , which is similar in structure and function (synthetic analogue) to
somatostatin

Interactions of Octreotide

Interactions with other medicines

Cyclosporine (medicine that suppresses the immune system)
High blood pressure medications of the class “Calcium channel blockers” (verapamil,
diltiazem, amlodipine, nifedipine etc)
Certain medicines used to treat heart disease (beta blockers – atenolol, metoprolol,
propranolol etc)
Antidiabetic medicines like insulin injection and tablets,
Bromocriptine (to treat high prolactin levels)
Exercise caution and inform your doctor of all medications that you are currently taking

Interactions with food items

It is better to take Octreotide between meals or just before bed time Allow some time between taking the medicine and having food

Dosage of Octreotide

Overdose

Accidental overdose with Octreotide may not be life-threatening Inform your doctor if you experience any symptoms like low blood pressure (dizziness, light-headed) or irregular heartbeats Extreme over...

Missed a Dose

Take the missed dose immediately if you remember 2-3 hours later. Otherwise, skip the missed dose and continue with the next dose. Do not take 2 doses together

Frequently Asked Questions (FAQs)

Q: Does Octreotide cure cancers? Is it an anti-cancer agent?

A: Octreotide will provide relief from the symptoms of certain cancers and may sometimes reduce the size of cancer by blocking the effects of growth hormone. But it is not an anti-cancer medicine and is not used to treat cancers

Q: Is there anything else I should know about Octreotide?

Do not self-medicate or self-adjust the dose of Octreotide. If you stop taking the
medicine on your own, it may lead to reappearance of symptoms and may lead
to unnecessary complications, because of the conditions for which Octreotide is
used.
Hence it is advised to consult your doctor if you stop taking the medicine or change the
dose.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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