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Norgestrel+Ethinylestradiol

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Molecule Summary

Uses
Oral contraceptive
Therapy
Female Hormone Pills
Side Effects
Nausea, vomiting, headache, stomach pain, diarrhoea
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Molecule Description

Norgestrel+Ethinylestradiol is a hormonal contraceptive pill that helps manage hormonal imbalances in females and also works as an effective method of birth control. It contains two hormones – Norgestrel and Ethinylestradiol, which work together to prevent pregnancy. The medicine works by stopping ovulation (the release of the egg), thickening cervical mucus to block sperm movement, and altering the uterine lining to prevent fertilization or implantation. Your doctor will prescribe Norgestrel+Ethinylestradiol based on your individual health needs. It is essential to take the medicine regularly, at the same time each day, for optimal effectiveness. You can take it with or without food, but avoid skipping doses, as this reduces its effectiveness in preventing pregnancy and controlling hormonal imbalances. If you miss a dose, follow your doctor's advice or check the patient information leaflet for specific instructions. Certain drug interactions may occur when taking Norgestrel+Ethinylestradiol. For example, anti-seizure medicines such as Lamotrigine, newer diabetes and weight management drugs like tirzepatide, and immunosuppressants like cyclosporine can interact with this pill. These interactions may reduce the pill's effectiveness or increase the risk of side effects. Always inform your doctor about any medicines or supplements you are currently taking. Norgestrel+Ethinylestradiol is not recommended for pregnant or breastfeeding women, as it may harm the baby. Women over the age of 35 who smoke regularly should also avoid this medicine, as the combination of smoking and hormonal contraceptives significantly increases the risk of blood clots, heart attacks, and stroke. It is always best to discuss your complete medical history with your doctor before starting Norgestrel+Ethinylestradiol. Like all medicines, Norgestrel+Ethinylestradiol may cause mild side effects, such as nausea, headache, breast tenderness, mood changes, or irregular bleeding. These are usually temporary, but if they persist or if you experience symptoms such as chest pain, severe headache, or shortness of breath, seek medical advice immediately. Along with medication, maintaining a healthy lifestyle, including a balanced diet and regular exercise, can support overall hormonal health.

Uses

Norgestrel+Ethinylestradiol is used in women as an oral contraceptive pill.

Contraindications

When should one not use Norgestrel+Ethinylestradiol

  • If you are allergic to ethinylestradiol, norgestrel or any other ingredients of Norgestrel+Ethinylestradiol.
  • If you are a smoker and over 35 years of age there is a risk of getting heart-related disorders.
  • If you have a history of any blood clot formation or bleeding disorder.
  • If you have heart-related disorders such as stroke, heart attack or angina.
  • If you have had migraine attacks and pancreas or liver or gallbladder-related problems.
  • If you have diabetes, high blood pressure or cholesterol-related disorder.
  • If you experience abnormal vaginal bleeding or delayed menses for more than three months (amenorrhea).
  • If you have or are suspected of having breast, vaginal, or cervical cancer.
  • If you have a psychiatric disorder and you feel low very often.
  • If you are taking anti-viral medicine for Hepatitis C and taking medicines such as Ombitasvir or Paritaprevir.

Side effects

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Headache
  • Stomach pain, cramps
  • Diarrhoea
  • Weight changes
  • Acne
  • Mood swings
  • Fatigue

Precautions and Warnings

Pregnancy

Pregnancy

Norgestrel+Ethinylestradiol should not be used during pregnancy. When pregnancy is detected, this medicine should be discontinued immediately.

Breast Feeding

Breast Feeding

Norgestrel+Ethinylestradiol should not be used during breastfeeding as it can alter milk production, and it also passes in breast milk. A lactating woman should use other types of contraceptives.

Driving

Driving

It is less likely to affect your driving abilities.

Alcohol

Alcohol

Though there is no direct interaction seen between alcohol and Norgestrel+Ethinylestradiol, alcohol can make you forgetful. Therefore, make sure you consume your pills before drinking alcohol or keep a reminder. Also, alcohol can induce emesis. Make sure you take the pill at least 2 hours before drinking alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a family history of breast cancer, seizures or other brain disorders.
  • You have high blood pressure, diabetes, lipid or cholesterol-related disorder.
  • Your liver or gall bladder is not functioning properly.
  • You have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
  • You have a blood-related disorder that has affected your kidneys(hemolytic uremic syndrome).
  • You have an immune-related disorder, such as systemic lupus erythematosus (SLE).
  • You have experienced pregnancy patches, especially on the face (chloasma).
  • You have a disease that first appeared during pregnancy like porphyria (an inherited haemoglobin defect), hearing loss, gestational herpes (vesicular skin rashes during pregnancy) and Sydenham's chorea (rapid, irregular movements of the body).
  • You have a family history or you have experienced allergic reactions causing rashes, breathing difficulty and swelling.
  • You are a woman above 35 years of age and smoke.
  • Oral contraceptives may alter the results of certain lab tests, inform the lab personnel before performing any test.

Mode of Action

How Does It Work?

Norgestrel+Ethinylestradiol is an oral contraceptive pill that contains both oestrogen and progestin. It works by preventing egg release (ovulation) and influencing sperm movement in the womb, preventing sperm union with the egg. It also alters the lining of the womb, making it unsuitable for pregnancy.

Interactions

Interactions with other medicines

  • Norgestrel+Ethinylestradiol may interact with other medicines, discuss with your doctor about all the medicines, supplements, or herbal preparations you are taking. Also, you should inform your doctor if you have a planned surgery or vaccination schedule.
  • Concomitant use of Norgestrel+Ethinylestradiol with anti-epileptics such as Phenytoin, Carbamazepine, Anti-HIV medicines such as Nevirapine, Ritonavir, antibiotics such as Penicillin, Griseofulvin, antiemetics such as Metoclopramide and herbal supplements like St.John's Wort may alter the effects of Norgestrel+Ethinylestradiol.
  • Anti-seizure medications like Lamotrigine and immunosuppressants like Cyclosporine should be avoided while on Norgestrel+Ethinylestradiol.
  • Norgestrel+Ethinylestradiol, if taken along with antiviral medicines, may affect your liver enzymes. Thus, this medicine should be stopped and can be resumed 2 weeks after completing the treatment.
  • Other medicines like Rifampicin and Carbamazepine should be used cautiously.

Interactions with food items

Norgestrel+Ethinylestradiol can be taken with or without food. However, it is recommended to take it at the same time every day, preferably after a meal, to reduce the risk of gastrointestinal upset and enhance absorption.

Dosage

Overdose

The symptoms of an overdose of Norgestrel+Ethinylestradiol include nausea, vomiting, or withdrawal bleeding. If you have taken more than the prescribed dose of this medicine, reach out to your doctor or nearest hospital.

Missed a Dose

Missing a dose of Norgestrel+Ethinylestradiol may reduce the effectiveness of contraception or cause contraceptive failure. If you missed any dose of Norgestrel+Ethinylestradiol, contact your doctor.

Frequently Asked Questions (FAQs)

You should take Norgestrel+Ethinylestradiol in doses and duration as per your doctor's advice. Try to take it at the same time everyday for effective contraception.

Norgestrel+Ethinylestradiol contains a combination of Ethinylestradiol and Norgestrel. Both of these components are the human-made form of female sex hormones oestrogen and progesterone.

No, you should not stop taking this medicine on your own. Consult your doctor before it. As these are hormonal pills stopping them can affect your physiological function.

No, Norgestrel+Ethinylestradiol is not meant for use in heavy periods.

Yes, Norgestrel+Ethinylestradiol can make you gain weight due to fluid retention.

Norgestrel+Ethinylestradiol is an oral contraceptive pill used by women to prevent pregnancy.

Norgestrel+Ethinylestradiol contains two types of female sex hormones - norgestrel and ethinylestradiol. Levonorgestrel+Ethinylestradiol contains levonorgestrel and ethinylestradiol, which are similar to the natural hormones in a woman's body. Both medicines are used as oral contraceptives in females. However, it is advised to use the medicine prescribed by your doctor, as the same shall be based on your diagnosis and medical history.

No, Norgestrel+Ethinylestradiol does not stop the periods. You may experience light periods or irregular periods while taking this medicine. Talk to your doctor for more information.

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