Naloxone

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NPPA
Regulated

Molecule Description

Naloxone is an Opioid antagonist which is used for the treatment of Opioid dependence and Opioid overdose.

Uses

Opioid overdose
Reversal of respiratory depression and other nervous system symptoms caused by Opioids
Reversal of respiratory depression and other CNs symptoms in newborn babies whose mothers have received Opioids during delivery

Contraindications

When should one not use Naloxone

Allergy to Naloxone.

Side effects

Common side effects of this drug are:

Sedation
Headache
Inability to concentrate
Difficulty in breathing
Fast heartbeat
Shaking
Fits
Change in blood pressure (low or high)
Fever
Sweating
Runny nose
Diarrhea
Feeling or being sick
Stomach cramps

Precautions and Warnings

Pregnancy

You should not take this medicine during pregnancy unless considered essential by your doctor.

Breast Feeding

It is not advised to take this medicine during breastfeeding. If considered necessary to be accompanied by a nursing mother, avoid breastfeeding for about 24 hours. Doctor’s advice is mandatory.

Driving

It is not recommended to drive or operate heavy machinery when taking this medicine.

Alcohol

It is considered unsafe to consume alcohol with this medicine.

Other General Warnings

Talk to your doctor if

Naloxone has to be given with caution in patients with Opioid overdose and addiction
Close monitoring by a doctor is needed
Withdrawal symptoms may occur
Tell your doctor if:
You experience any discomfort or breathing trouble after taking this medicine
You have an allergy to this medicine
All your medical conditions and ongoing treatments

Mode of Action

How Does It Work?

This medicine works by blocking or reversing the effects of Opioids, including difficulty in breathing, sedation and low blood pressure.

Interactions

Interactions with other medicines

Decreased effects of Opioid Analgesic Naltrexone
Buprenorphine
MAO inhibitor medicines like Isocarboxazid, Linezolid, etc.
Fluoxetine
Cardiopulmonary effects may occur with cardiotoxic medicines

Interactions with food items

No interaction with food has been reported yet.

Dosage

Overdose

This medicine is used to treat Opioid overdose and is mostly administered by a healthcare professional in a calculated dose. Hence, overdose of this medicine is extremely rare. Additionally, it is a fast-acting medicine with short half-life and is thrown out of the body very quickly. Excesses if at all, will be eliminated by the body soon.

Missed a Dose

If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue with your regular dosage schedule. Do not take a double dose of medicine to compensate for a missed one.

Frequently Asked Questions (FAQs)

Give a detailed account of your medical, surgical and allergy history. The doctor should also know about other health supplements like herbal medications, nutritional supplements that you may take before starting this medication.

The dosage regimen of the medicine should be followed regularly. Any dose miscalculation will have severe effects.

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