Midazolam

• As per CDSCO, Midazolam is used for the treatment of:
• Preoperative sedation
• Induction of general anaesthesia

When should one not use Midazolam

• If you are allergic to Midazolam
• If you have narrow-angle glaucoma (increased pressure in the eye)
• If you have low blood pressure or shock-like condition

Common side effects of this drug are:

• Sleepiness
• Dizziness
• Sneezing
• Hiccups
• Shallow breathing
• Pain at the injection site

Other General Warnings

• You have an allergic reaction after receiving Midazolam.
• You have hypoventilation or apnea.
• You have low blood pressure.
• You have a cough, breathing issues, or any other respiratory illness.
• You experience severe side effects persistently.
• You use other prescription medications or Ayurvedic/ herbal medicines, vitamins and other health supplements. These may interact with Midazolam.
• You are an older adult over 60 years of age.
• You are pregnant or breastfeeding. Talk to your doctor before use.
• You have severe kidney or liver disease.
• You have a history of drug abuse.

How Does It Work?

Interactions with other medicines

• Interaction of Midazolam with pain killers, such as morphine, oxycodone, fentanyl, hydrocodone, tramadol, and codeine, may lead to extreme sedation and drowsiness.
• Midazolam should not be used concomitantly with monoamine oxidase inhibitors (MAOIs) like isocarboxazid, linezolid, methylene blue, selegiline, rasagiline, etc. as they can cause serious side effects like decreased breathing, low heart rate, etc.
• Interaction with ketoconazole, fluconazole, and itraconazole increases the plasma concentrations of Midazolam.
• Interaction with other benzodiazepines potentiates the anaesthetic effects of Midazolam.

Overdose

Missed a Dose