Hydralazine+Isosorbide Dinitrate
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Molecule Summary
| Uses | Heart failure |
| Therapy | Drugs For Congestive Heart Failure |
| Side Effects | Headache, dizziness, nausea, fatigue, low blood pressure |
Medicines
available
19k pincodes
Molecule Description
Hydralazine+Isosorbide Dinitrate is a medicine that is used to treat heart failure. It is a combination of two medicines called hydralazine and isosorbide dinitrate. These medicines work by relaxing the blood vessels, which makes it easier for your heart to pump blood.
Hydralazine+Isosorbide Dinitrate is taken as directed by your doctor, with or without food. It is important to take it regularly, even if you feel well. Do not stop taking Hydralazine+Isosorbide Dinitrate without talking to your doctor first. Some common side effects of Hydralazine+Isosorbide Dinitrate include headache and dizziness. These side effects are usually mild and go away on their own. If you experience any severe side effects, contact your doctor right away.
Uses
Hydralazine+Isosorbide Dinitrate is used in the treatment of heart failure as an adjunct to standard therapy.
Contraindications
When should one not use Hydralazine+Isosorbide Dinitrate
- If you are allergic to hydralazine, isosorbide dinitrate or any other ingredient of this medicine.
- It should not be used in patients taking medicines containing sildenafil, avanafil, tadalafil or vardenafil (used for treating erectile dysfunction in men).
- If you are taking a medicine called riociguat which is used to treat high blood pressure in the lungs (pulmonary hypertension).
Side effects
Common side effects of this drug are:
- Headache
- Dizziness
- Nausea
- Fatigue
- Low blood pressure
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have heart-related problems.
- You have severe kidney or liver problems.
- You are having any surgery.
- You have glaucoma (increased pressure in the eye).
- You are undernourished.
- You are suffering from hypothermia (a condition in which your body loses heat faster than it can produce).
- You have suffered from bleeding in the brain.
- You have an underactive thyroid gland.
- You experience headache, nausea, dizziness, fainting (symptomatic hypotension).
- You experience any abnormal sensation on your skin such as numbness and tingling.
- You have systemic lupus erythematosus (an autoimmune disorder), this medicine may induce this condition.
- You suffer from a deficiency of an enzyme called glucose 6 phosphate dehydrogenase.
Mode of Action
How Does It Work?
Hydralazine+Isosorbide Dinitrate contains isosorbide dinitrate and hydralazine which work by relaxing the blood vessels and hence make the blood flow easy.
Dosage
Overdose
If you have taken an excess of Hydralazine+Isosorbide Dinitrate and experience side effects such as headache, uneven heart rhythm then contact your doctor immediately or go to the nearest hospital.
Missed a Dose
If you have missed taking a dose of Hydralazine+Isosorbide Dinitrate take it as soon as possible. Skip the dose if it's already time for the next dose. Do not double the dose.
Frequently Asked Questions (FAQs)
Articles
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References:
- Hydralazine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2021 [cited 14 June 2026]
- Isosorbide dinitrate [Internet]. Pubchem.ncbi.nlm.nih.gov. 2021 [cited 14 June 2026]
- Hydralazine+Isosorbide Dinitrate [Internet]. Accessdata.fda.gov. 2021 [cited 14 June 2026]
- Isosorbide Dinitrate Tablets BP 10mg - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 14 June 2026]
- Isosorbide Dinitrate Tablets [Internet]. Medicines.org.uk. 2021 [cited 14 June 2026]
- National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 3637, Hydralazine. Retrieved January 9, 2025
- Balasubramanian S, Chowdhury YS. Isosorbide. [Updated 2023 May 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 May, [Accessed 14 June 2026].
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