Insulin Glargine+Lixisenatide

When should one not use Insulin Glargine+Lixisenatide

Common side effects of this drug are:

• Hypoglycaemia
• Dizziness
• Nausea
• Diarrhoea
• Vomiting

Other General Warnings

• You have type 1 diabetes, as Insulin Glargine+Lixisenatide is only for type 2 diabetes and will not work properly for you.
• You have diabetic ketoacidosis, a serious condition that requires different treatment.
• You have severe stomach problems, such as delayed stomach emptying (gastroparesis), since Insulin Glargine+Lixisenatide has not been studied in such conditions.
• You are planning to have surgery under anaesthesia, as your treatment may need adjustments.
• You have severe kidney disease or are on dialysis, because Insulin Glargine+Lixisenatide is not recommended in such cases.
• You experience severe or lasting stomach pain, which could be a sign of pancreatitis.
• You have frequent vomiting or diarrhoea, as this may cause dehydration, especially in the early weeks of treatment.
• You are injecting into lumpy or hardened skin, as it may affect how the insulin works.
• You are travelling, so discuss time zone changes, medicine availability, storage, and emergency plans with your doctor.

How Does It Work?

• Insulin glargine is a long-acting insulin that helps control your blood sugar levels throughout the day and night. After it is injected, it slowly releases into your body, providing a steady amount of insulin. This helps your body utilise sugar from your blood for energy and prevents high blood sugar levels, especially between meals and during sleep.
• Lixisenatide is a medicine that helps lower blood sugar in people with type 2 diabetes. It works by helping your body release the right amount of insulin when your blood sugar levels are high, slowing down how quickly food leaves your stomach, and reducing the amount of sugar your liver produces. This helps keep your blood sugar levels more stable, especially after meals.

Interactions with other medicines

• Some medications may increase the risk of low blood sugar when used in combination with Insulin Glargine+Lixisenatide, including other diabetes medications, ACE inhibitors, certain antidepressants (such as fluoxetine and monoamine oxidase inhibitors), salicylates (e.g., aspirin), and some antibiotics and cardiovascular medications.
• Other medicines, like steroids, diuretics, thyroid hormones, hormone replacement therapy, and some antipsychotics, may raise blood sugar levels and reduce how well Insulin Glargine+Lixisenatide works.
• Blood pressure drugs like beta-blockers, as well as alcohol and certain psychiatric medications, can hide signs of low blood sugar or change how Insulin Glargine+Lixisenatide works.
• Medicines such as octreotide, lanreotide, and warfarin may require additional monitoring or dosage adjustments when used in combination with Insulin Glargine+Lixisenatide.
• Insulin Glargine+Lixisenatide can slow down digestion, which may reduce the effectiveness of certain medications, such as antibiotics or those that require precise timing of administration. These should be taken at least 1 hour before or 4 hours after the medicine.
• Paracetamol, birth control pills, atorvastatin, warfarin, digoxin, and ramipril are slightly affected by Insulin Glargine+Lixisenatide, but no dose changes are usually needed. Your healthcare provider will check if close monitoring is needed for blood thinners like warfarin.

Overdose

Missed a Dose