Indapamide+Olmesartan Medoxomil
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Molecule Summary
| Uses | High blood pressure |
| Therapy | Anti-Hypertensive |
| Side Effects | Vomiting, dizziness, excessive urination, headache, nausea, stomach pain |
Assurance
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Regulated
Molecule Description
Indapamide+Olmesartan Medoxomil is a combination medicine used to treat high blood pressure by working on the kidneys and blood vessels. Indapamide is a diuretic that helps the kidneys remove excess water and salt from the body. This reduces the volume of blood the heart must pump, thereby lowering blood pressure and reducing strain on the heart. Olmesartan works by blocking the angiotensin II receptor, which normally constricts blood vessels. Relaxing and dilating the vessels facilitates blood flow and further reduces blood pressure. Together, these two actions help protect the heart, kidneys, and blood vessels from damage caused by hypertension.
This medicine helps lower the risk of complications related to high blood pressure, such as heart attack, stroke, and kidney problems. Reducing fluid overload and relaxing blood vessels allows the heart to pump more efficiently and helps maintain stable blood pressure throughout the day.
It is important to follow a low-salt diet and avoid alcohol while taking this medicine. These lifestyle steps complement the medication and help maintain better blood pressure control. Regular monitoring of blood pressure, kidney function, and electrolytes helps ensure that the medication is working effectively and safely.
Patients should inform their doctor about all other medications, supplements, or herbal products they are taking, as some drugs can interact and affect the medicine's action or increase side effects. Taking the medicine at the same time each day and not missing doses helps maintain consistent blood pressure control and improves overall heart and kidney health.
Uses
Indapamide+Olmesartan Medoxomil is used in the treatment of high blood pressure.
Contraindications
When should one not use Indapamide+Olmesartan Medoxomil
- If you are allergic to indapamide, olmesartan, or any other ingredients of Indapamide+Olmesartan Medoxomil.
- If you are pregnant.
- If you are suffering from jaundice.
- If you have severe kidney disease.
- If you are using any medicine containing aliskiren.
Side effects
Common side effects of this drug are:
- Headache
- Dizziness
- Nausea
- Stomach pain
- Diarrhoea
- Indigestion
- Tiredness
- Body pain
- Chest pain
- Flu-like symptoms
- Cough
- Runny or stuffy nose
- Sore throat
- Swelling
- Blood in the urine
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You suffer from any heart diseases.
- You have kidney or liver problems.
- You have diabetes or gallbladder problems.
- You have diarrhoea and vomiting.
- You are receiving high-dose diuretics (furosemide, hydrochlorothiazide).
- You are on a low-salt diet.
- Your doctor has told you that you have high blood potassium levels.
- You have an adrenal gland disorder.
- You are taking other medications to treat high blood pressure, such as Ramipril, Lisinopril, and Aliskiren.
- Indapamide+Olmesartan Medoxomil is not recommended for children below the age of 6 years.
Mode of Action
How Does It Work?
- Indapamide is a water pill. It works by acting on the kidneys. It increases urinary output, thereby increasing the excretion of water and salt from the body. This helps in reducing cardiac output and blood pressure.
- Olmesartan works by blocking a substance in the body that causes blood vessels to tighten, thereby relaxing them and allowing blood to flow more easily.
Interactions
Interactions with other medicines
- Before starting Indapamide+Olmesartan Medoxomil, inform your doctor about all the medicines you take, including herbal, vitamins & mineral supplements.
- This medication, when taken with other antihypertensive medications such as benazepril, captopril, and lisinopril, may alter its effects.
- Concomitant use along with medicines used in heart diseases and high blood pressure, like perindopril, candesartan, and aliskiren, may increase the risk of side effects with this medicine.
- Concomitant use of this medicine with potassium supplements, medications such as amiloride, and spironolactone is not recommended, as it may increase blood potassium levels.
- Medicines like aspirin, ibuprofen, etc, may lead to kidney failure when taken together with this medicine.
- Lithium should not be taken simultaneously with this medicine.
- This medicine should be taken at least 4 hours before Colesevelam (used to reduce blood cholesterol and fatty substances).
Interactions with food items
Indapamide+Olmesartan Medoxomil can be taken either before or after your meals.
Dosage
Overdose
If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you miss any dose of Indapamide+Olmesartan Medoxomil, take it as soon as you remember. However, if it is time for the next dose, then skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
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References:
- Zentiva Pharma UK Limited. Indapamide 2.5 mg tablets: Summary of Product Characteristics [Internet]. UK: Datapharm Ltd.; last updated 03 Mar 2023 [cited 2026 Jun 8].
- Thornton & Ross Ltd. Olmesartan 20 mg film‑coated tablets: Patient Information Leaflet (PIL) [Internet]. UK: Datapharm Ltd.; last updated 02 Jul 2025 [cited 2026 Jun 8].
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