Imatinib
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Molecule Summary
| Uses | Blood cancer, cancer of the stomach or intestine |
| Therapy | Anti-Neoplastic |
| Side Effects | Headache, dizziness, cough, nausea |
Medicines
available
19k pincodes
Molecule Description
Imatinib is a medication classified as an anti-cancer medicine. It is commonly prescribed for treating specific types of blood cancer, such as chronic myeloid leukaemia, as well as cancers of the stomach and intestines. This medicine works by slowing or halting the growth of abnormal cancer cells, helping to control the spread of the disease.
While taking Imatinib, some individuals may experience side effects. The most common include nausea, vomiting, swelling (oedema), diarrhoea, muscle cramps, fatigue, abdominal pain, and skin rashes. These effects are typically manageable, but you should always inform your doctor if they become severe or troublesome. A warning sign to watch for is sudden or rapid weight gain, which should be reported immediately to your doctor as it may indicate fluid retention.
It is important to take Imatinib exactly as prescribed by your doctor. Swallow it with a glass of water, preferably with a meal to minimise stomach upset. Do not stop or skip doses on your own, as this may decrease the treatment's effectiveness. If you experience dizziness or blurred vision, avoid driving or operating machinery until you feel better.
Before beginning treatment, inform your doctor of your complete medical history, including conditions such as liver, kidney, or heart problems, thyroid disorders, or if you have had your thyroid gland removed. Also, if you have ever had hepatitis B infection, mention this to your doctor because the medication can sometimes reactivate the virus. Your doctor may recommend regular blood tests to monitor your response and detect any potential side effects.
While using Imatinib, always be vigilant for warning signs such as easy bruising, bleeding, fever, extreme tiredness, or confusion. These may indicate changes in your blood cells and should be reported promptly to your healthcare provider. Following your doctor's instructions carefully, maintaining a healthy diet, and attending regular follow-up appointments will help you achieve the best results from your treatment while reducing risks.
Uses
Imatinib is used to treat various types of cancers. It is most commonly prescribed for blood cancers (chronic myeloid leukaemia and acute lymphocytic leukaemia) and gastrointestinal stromal tumours.
Contraindications
When should one not use Imatinib
If you are allergic to Imatinib or any of the ingredients of this medicine
Side effects
Common side effects of this drug are:
- Headache
- Dizziness
- Cough
- Nausea
- Vomiting
- Stomach pain
- Diarrhoea
- Weight gain
- Insomnia
- Taste disturbance
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have or have had a Hepatitis B infection.
- You gain weight very quickly.
- You have problems with your heart, liver, or kidneys.
- You are taking levothyroxine medication
- You experience fever, tiredness, bruising, confusion, and bleeding after taking Imatinib.
- Avoid unnecessary exposure to sunlight and wear full-sleeved clothes.
Mode of Action
How Does It Work?
Imatinib works by slowing down or stopping the growth of cancerous cells. Hence, it helps in stopping the spread of cancer.
Interactions
Interactions with other medicines
- Some medicines can affect the way Imatinib works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbal products you are currently taking or might take to avoid any possible interactions.
- Especially if you are taking medicines to treat heart problems, infections, psychiatric illnesses, fits, etc or are taking antibiotics, blood thinners, paracetamol, St John's Wort
Interactions with food items
- Take Imatinib with food and a full glass of water to reduce stomach upset.
- Avoid grapefruit and grapefruit juice, as they can increase the blood levels of imatinib and potentially raise the risk of side effects.
- Limit alcohol consumption, as it can worsen dizziness, fatigue, and liver-related side effects.
- Follow a balanced diet rich in fruits, vegetables, and proteins to maintain strength during treatment.
- Drink plenty of water to stay hydrated, as dehydration can exacerbate side effects such as fatigue and weakness.
Dosage
Overdose
- Symptoms of overdose include nausea, vomiting, diarrhoea, rash, redness, swelling, tiredness, muscle pain, low blood count, abdominal pain, headache and decreased appetite.
- If you think you have taken too much of Imatinib, then contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed any dose of this medicine, take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
Articles
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References:
- Imatinib film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 8 Jun 2026]
- GLEEVEC (imatinib mesylate) tablets for oral use, USP [Internet]. Accessdata.fda.gov. 2025 [cited 8 Jun 2026]
- MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2025 [cited 8 Jun 2026]
- Imatinib film-coated tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 8 Jun 2026]
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