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Granisetron

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Molecule Summary

Uses
Nausea and vomiting associated with cancer medications, radiotherapy
Therapy
Anti-Emetic
Side Effects
Headache, constipation, diarrhoea, weakness
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Molecule Description

It is used in treating nausea and vomiting, which are associated with cancer medications, radiotherapy or any surgery. If you are allergic to this medicine, then avoid taking it. Take this medicine in doses and duration as prescribed by the doctor. Do not stop taking this medicine suddenly without informing your doctor. The common side effects of Granisetron are diarrhoea, headache and constipation. Most of which are temporary, but if you feel the side effects persist or your condition worsens, then you should contact your doctor immediately.

Uses

Granisetron is used to treat nausea and vomiting, which may be due to cancer medicines or radiotherapy.

Contraindications

When should one not use Granisetron

If you are allergic to Granisetron or any of the ingredients of Granisetron.

Side effects

Common side effects of this drug are:

  • Headache
  • Constipation
  • Diarrhoea
  • Weakness
  • Lack of sleep
  • Increased liver enzymes

Precautions and Warnings

Pregnancy

Pregnancy

You should consult your doctor before using Granisetron, as there is limited information about its safety during pregnancy. Your doctor will prescribe you this medicine if considered essential after assessing the benefits over risks.

Breast Feeding

Breast Feeding

Avoid the use of this medicine if you are breastfeeding because no information is available on the use of Granisetron during breastfeeding. Consult with your doctor before breastfeeding.

Driving

Driving

It is not expected that Granisetron will affect your ability to drive, but if you do not feel well or are unable to be alert, you should avoid driving.

Alcohol

Alcohol

It is advisable not to consume alcohol along with Granisetron, as alcohol consumption during the treatment can affect the heart's rhythm.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You may experience symptoms like vomiting, stomachache, constipation, difficulty in passing stools due to blockage in your intestine, as this medicine may reduce your bowel movement. Caution is exercised in patients with heart problems like irregular heartbeats.
  • You are taking medicines like dolasetron, ondansetron along with granisetron, as there are chances of cross-sensitivity.
  • You may experience symptoms like high body temperature, sweating, shivering, fits and confusion and other mental changes (serotonin syndrome), in such a situation, appropriate observation is required.

Mode of Action

How Does It Work?

After chemo or radiotherapy, serotonin is the main chemical substance responsible for vomiting. Granisetron works by inhibiting the action of this serotonin (body's chemical) and prevents the feeling of nausea and vomiting.

Interactions

Interactions with other medicines

  • Simultaneous use of Granisetron along with medicines used to treat an irregular heartbeat, other medicines like dolasetron or ondansetron, can affect the heart activity.
  • Concomitant use of Granisetron and medicines used to treat anxiety and to treat depression like fluoxetine, paroxetine, sertraline, venlafaxine, duloxetine, etc can cause symptoms like high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, etc. (serotonin syndrome).

Interactions with food items

Absorption of Granisetron is not influenced by any food.

Dosage

Overdose

  • There are no symptoms of an overdose, but sometimes you may feel a mild headache.
  • If you think you have taken too much of Granisetron and experience any unusual symptoms, then contact your doctor immediately or visit the nearest hospital.

Missed a Dose

  • If you missed any dose of Granisetron, then take it as soon as you remember.
  • If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule.
  • Do not take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

You need to tell your doctor if you are suffering from any kind of medical condition. Also, tell your doctor about the medicines you are already taking.

You should not stop taking Granisetron before completing the treatment. If you do stop taking your medicine, then your symptoms may return. You need to speak to your doctor first if you wish to discontinue taking this medicine.

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