Glimepiride+Metformin Hydrochloride
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Molecule Summary
| Uses | Type 2 Diabetes mellitus |
| Therapy | Anti-Diabetic |
| Side Effects | Headache, nausea, vomiting, sleepiness, low blood sugar |
Medicines
available
19k pincodes
Molecule Description
Glimepiride+Metformin Hydrochloride is a medication used to treat type 2 diabetes mellitus. It contains glimepiride and metformin as its active ingredients. This medication helps increase insulin production and restore the body's natural response to insulin. As a result, it helps control blood sugar levels and reduces the risk of other health conditions associated with high blood sugar. It is typically used in combination with a healthy diet and regular exercise.
Glimepiride+Metformin Hydrochloride should be taken as directed by your doctor. While taking this medicine, headache, nausea, vomiting, sleepiness, and a drop in blood sugar levels are a few common side effects that may occur during treatment. Although not everyone experiences them, side effects often improve as the body becomes accustomed to the medicine.
Glimepiride+Metformin Hydrochloride should not be taken by individuals who are allergic to metformin or glimepiride, or who have kidney or liver failure, or metabolic acidosis. It is also contraindicated in pregnant or breastfeeding women. You should inform your doctor about all other medications, supplements, and health conditions you are taking to prevent potential interactions. It is essential to continue taking the medication as prescribed, even if symptoms improve, and not to discontinue it without a doctor's guidance.
Uses
Glimepiride+Metformin Hydrochloride is used to treat type 2 diabetes mellitus; when diet, exercise and glimepiride or metformin alone is not able to control the blood sugar levels.
Contraindications
When should one not use Glimepiride+Metformin Hydrochloride
- If you are allergic to metformin, glimepiride or other ingredients of this medicine.
- If you are pregnant or are breastfeeding.
- If you have kidney or liver failure.
- If you have metabolic acidosis (too much acid in the body fluids) like lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
- If you suffer from dehydration, severe infections, shock and injections containing iodine.
- If you have had heart or lung failure, the incidence of heart attack and shock.
- If you are an alcoholic.
Side effects
Common side effects of this drug are:
- Headache
- Nausea
- Vomiting
- Sleepiness
- Low blood sugar level
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You experience symptoms like hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness, or dizziness, it could be a sign of low blood sugar. Have some sugar or sweet juice and inform your doctor.
- You experience a pins-and-needles sensation, numbness, and weakness.
- You are undergoing a diagnostic imaging test that involves iodine injection.
- You suffer from dehydration due to diarrhoea, vomiting or limited fluid intake.
- You have suffered through trauma.
- You are undergoing surgery shortly.
- You have or have had thyroid, kidney, and liver disease.
- You skip meals or have irregular mealtimes.
- You are experiencing weight gain (a specific diet restriction may be suggested).
Mode of Action
How Does It Work?
Glimepiride+Metformin Hydrochloride manages type 2 diabetes with metformin and glimepiride. Metformin decreases liver glucose production and enhances insulin sensitivity, while glimepiride boosts insulin production in the pancreas. Together, they lower and stabilize blood sugar levels, reducing complication risks.
Interactions
Interactions with other medicines
- Inform the physician about any medicines, supplements, or herbal products you take or may take to avoid potential interactions.
- You may suffer from symptoms of low blood sugar if you are taking other medicines for diabetes, such as Insulin, Pioglitazone, medicines for high blood pressure (ACE inhibitors like Captopril), Steroids, Chloramphenicol, Fenfluramine, medicines to lower blood cholesterol (fibrates), medicines to treat depression (Fluoxetine), and medicines to treat blood clotting, like Coumarins, Cyclophosphamide, Miconazole, Probenecid, and antibiotics like Clarithromycin, Doxycycline, Ofloxacin, etc.
- You may have symptoms of high blood sugar if you are taking oral contraceptives, Acetazolamide, water pills, Phenytoin, Rifampicin, medicines for constipation, and medicines for thyroid disorders.
- Medicines like antiallergics (Ranitidine), clonidine, reserpine, and high blood pressure medications like Atenolol alter the way this medicine works and may block the body's response to low blood sugar. This leads to dangerously low blood sugar levels.
- Medicines like Diclofenac, Ibuprofen, water pills, and Enalapril may affect kidney function if taken alongside this medicine.
- Medicines used to treat thyroid conditions affect how they work.
- Glimepiride+Metformin Hydrochloride may be used together with insulin if prescribed by a doctor, but the combination should be monitored carefully to reduce the risk of low blood sugar and ensure dose adjustment when needed.
Interactions with food items
Glimepiride+Metformin Hydrochloride should be taken with food at the same time each day to ensure the best results.
Dosage
Overdose
- An overdose of Glimepiride+Metformin Hydrochloride may lead to hypoglycemia (low blood sugar) and lactic acidosis (Excessive lactic acid build-up).
- This results in headache, nausea, vomiting, sleep disturbances, restlessness, impaired alertness and reactions, depression, confusion, dizziness, etc.
- If you experience these symptoms, take glucose or juice or sugar-containing products (sugar candy) and contact the doctor or visit the nearest hospital as you may require close monitoring for the next few hours.
Missed a Dose
- A missed dose may lead to high blood sugar levels, which includes symptoms like feeling thirsty, excessive urination, loss of appetite, dry mouth, the fruity smell from breath, etc.
- If you have missed taking a dose of Glimepiride+Metformin Hydrochloride, take it as soon as you remember.
- If it's time for the next dose, skip the missed dose and continue with the regular dose schedule.
- Avoid taking a double dose to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- Glimepiride 1 mg Tablets - Summary of Product Characteristics (SmPC) - (EMC) [Internet]. Medicines.org.uk. 2025 [cited 3rd Jun 2026]
- Glimepiride 1 mg Tablets - Patient Information Leaflet (PIL) - (EMC) [Internet]. Medicines.org.uk. 2025 [cited 3rd Jun 2026]
- Metformin 500 mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 3rd Jun 2026]
- Metformin 500 mg film-coated Tablets - Patient Information Leaflet (PIL) - (EMC) [Internet]. Medicines.org.uk. 2025 [cited 3rd Jun 2026]
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