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Molecule Description

This medicine is a carboxylic acid derivative. It belongs to a group of medicines called 'reversible aldose reductase inhibitor' used for the treatment of diabetic neuropathy.

Uses of Epalrestat

To treat nerve damage due to diabetes mellitus

Contraindications of Epalrestat

When should one not use Epalrestat

  • Allergy to this medicine
  • Severe liver insufficiency

Side effects of Epalrestat

Common side effects of this drug are:

  • Stomach discomfort
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Allergic skin rash and itching

Precautions and Warnings of Epalrestat


Can I take Epalrestat during pregnancy?
There are no adequate studies available. It is not recommended to use this medicine during pregnancy. Do not take this medicine without doctor’s advice.

Breast Feeding

Can I take Epalrestat while breastfeeding?
No adequate studies available. It is not recommended to use this medicine during breastfeeding. Do not take this medicine without doctor’s advice.


Can I drive if I have consumed Epalrestat?
No specific information available


Can I consume alcohol with Epalrestat?
No specific information available about interactions of this medicine with alcohol.

Other General Warnings

Talk to your doctor if
  • Tell your doctor if:
  • You experience any discomfort, rashes, swelling after taking this medicine
  • About all your medical conditions and ongoing medications

Mode of Action of Epalrestat

How Does It Work?

It suppresses the accumulation of sorbitol in nerve by inhibiting aldose reductase. It relieves numbness/ pain of the hands, feet, leg cramps, etc. which are the commonly experienced complications of diabetes.
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Interactions of Epalrestat

Interactions with other medicines

No specific data available for medicine interactions

Interactions with food items

No information is available on interactions of this medicine when taken with food, consult your doctor or pharmacist for further information.

Dosage of Epalrestat


Seek emergency medical attention or poison help if you think you have used too much of this medicine. Overdose symptoms have not been reported well in scientific literature.

Missed a Dose

If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.
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Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

A: Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.

Q: When and how to consume this medicine?

A: Take this medicine orally with a glass of water exactly as directed by your doctor. Follow the instructions given on the prescription label.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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