Doxepin

• According to CDSCO, Doxepin is used in:
• Treatment of insomnia
• Treatment of unresponsive depression cases to first-line treatment
• As second-line treatment for anxiety disorder

When should one not use Doxepin

• If you are using or have recently taken monoamine oxidase inhibitors (MAOIs); avoid using this medication.

Common side effects of this drug are:

• Increased heart rate
• Weight gain
• Dry mouth
• Orthostatic hypotension (a drop in blood pressure on standing)
• Constipation
• Difficulty in urination

Other General Warnings

• You observe behavioural changes, mood changes, or suicidal thoughts while taking this medication.
• You experience agitation, slowed breathing, convulsions, muscle rigidity, or mouth dryness.
• Your regular blood tests (including tests for salt and sugar levels) show any abnormalities. It is important to do routine tests while on this medication.
• You wish to stop taking Doxepin. Do not stop abruptly; speak with your doctor.
• You gain or lose weight or feel that your appetite is affected.
• You are a child under 12. Doxepin is not meant for this age group.
• You have kidney disease, liver disease (dose adjustment may be needed) or high blood pressure.

How Does It Work?

Interactions with other medicines

• Following the use of midazolam with Doxepin, serious cardiorespiratory adverse responses have occurred, occasionally leading to death or irreversible neurologic sequelae.
• Antihistamines and some cough and cold medicines can interact with Doxepin. The interaction can lead to drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory issues.

Overdose

Missed a Dose