Domperidone+Paracetamol / Acetaminophen
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Molecule Summary
| Uses | Migraine attacks |
| Therapy | Analgesic/Antipyretic, Anti-Emetic |
| Side Effects | Dry mouth, sleepiness, diarrhea |
Medicines
available
19k pincodes
Molecule Description
Domperidone+Paracetamol / Acetaminophen is used to treat migraines and may also be used for other medical conditions, such as fever and pain associated with nausea and vomiting. A migraine is a type of headache characterized by varying degrees of pain, often accompanied by nausea, vomiting, and sensitivity to light and sound.
The active ingredients in Domperidone+Paracetamol / Acetaminophen are domperidone and paracetamol (also known as acetaminophen). This medication works by blocking the release of the chemicals responsible for pain and inflammation related to the sensation of vomiting.
It is important to take Domperidone+Paracetamol / Acetaminophen as advised by your doctor regarding meals, and to follow your doctor's prescribed instructions regarding dosage and duration of treatment. Be sure to inform your doctor about all other medical conditions and medications you are currently taking.
Dry mouth, diarrhoea, sleepiness, tiredness, and skin rashes can be side effects of this medicine in some individuals. If side effects bother you, please inform your doctor. Domperidone+Paracetamol / Acetaminophen should not be used in children below 5 years of age.
Uses
Domperidone+Paracetamol / Acetaminophen is used for the treatment of migraines. It also provides relief from various conditions associated with nausea, vomiting, pain and fever.
Contraindications
When should one not use Domperidone+Paracetamol / Acetaminophen
- If you are allergic to domperidone, paracetamol or any other ingredients of Domperidone+Paracetamol / Acetaminophen.
- If you have any problems with your heart, liver or kidneys.
- If you have stomach or intestinal ulcers, bleeding from ulcers.
- If you have an obstruction, blockage or tear in the intestine or in any part of the gut.
- If you are suffering from a condition called prolactinoma (a tumour in your pituitary gland which releases an excess of prolactin hormone).
Side effects
Common side effects of this drug are:
- Dry mouth
- Diarrhoea
- Sleepiness
- Tiredness
- Skin rash
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Your symptoms persist for more than 3 days.
- You are suffering from any problems with your heart, liver or kidney.
- You are on medications like ketoconazole or erythromycin.
- You are taking any other medicine containing paracetamol or domperidone.
- Domperidone+Paracetamol / Acetaminophen should not be used in children below 5 years of age.
Mode of Action
How Does It Work?
- Domperidone+Paracetamol / Acetaminophen works by the combined effects of both its components - domperidone and paracetamol.
- Domperidone is used to control nausea and vomiting caused due to migraine. It acts by increasing the motility of the stomach and intestines.
- Paracetamol works by blocking the release of certain chemical substances which cause pain and fever. So, all the symptoms related to migraine improve gradually.
Interactions
Interactions with other medicines
- Some medicines can affect the way Domperidone+Paracetamol / Acetaminophen works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
- In particular, if you are taking medicines like ketoconazole (to treat fungal infection) or erythromycin (antibiotic).
- Concomitant use of Domperidone+Paracetamol / Acetaminophen along with blood thinners like warfarin can increase the risk of bleeding.
- Other medicines like Metoclopramide, Cholestyramine, and Chloramphenicol should be used with caution along with Domperidone+Paracetamol / Acetaminophen.
Interactions with food items
Take Lornoxicam+Paracetamol / Acetaminophen as advised by your doctor regarding meals.
Dosage
Overdose
Symptoms of an overdose may be nausea, vomiting, stomach pain, loss of appetite, agitation, unconsciousness, fits, confusion, sleepiness and pale skin. Seek medical attention in case you have consumed too much of Domperidone+Paracetamol / Acetaminophen.
Missed a Dose
If you have missed any dose of Domperidone+Paracetamol / Acetaminophen take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 3151, Domperidone. 2025 [cited 15th Jun 2026]
- Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007 Sep;102(9):2036-44. 2025 [cited 15th Jun 2026]
- Gerriets V, Anderson J, Patel P, et al. Acetaminophen. [Updated 2024 Jan 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. 2025 [cited 15th Jun 2026]
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