Domperidone
Molecule Description
Domperidone is an anti-sickness medicine. It is used for the treatment of nause
a and vomiting. It increases the movement of food into the stomach, thereby helps in indigestion. It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach). It belongs to the anti-emetic (emesis - vomiting) group of medicines. Domperidone is available in the form of a tablet, capsule, syrup, suspension, oral drops, rectal suppository. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting domperidone.
Uses of Domperidone
- Domperidone is used to relieve nausea and vomiting.
- It increases the movement of food into the stomach, thus helps in indigestion.
- It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach).
Contraindications of Domperidone
When should one not use Domperidone
- If you are allergic to domperidone or similar medicines
- If you have problems with your heart, liver or kidney
- If you have a blockage or tear in the intestines
- If you have a low level of potassium or magnesium or a high level of potassium in your blood
- If you have a tumour of the pituitary gland called a prolactinoma
- If you have black, tarry bowel stools or blood in stools
Side effects of Domperidone
Common side effects of this drug are:
- Dry mouth
- Drowsiness
- Headache
- Fatigue
- Sleepiness
Precautions and Warnings of Domperidone
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have problems with your liver or kidneys
- You are allergic to or develop any allergic reactions after taking the medicine.
- You experience palpitations, breathing problems or unconsciousness after domperidone.
Mode of Action of Domperidone
How Does It Work?
Interactions of Domperidone
Interactions with other medicines
- Some medicines can affect the way domperidone works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are taking medicines to treat heart problems, psychiatric illnesses, problems related to stomach and intestines, cancer, malaria, HIV infection, allergy, fungal or bacterial infections....
Content Details
Dr. Mansi Savla
B. Pharm, PharmD
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: In which all dosage forms is domperidone available?
Q: How does domperidone work?
References
- CDSCO - Domperidone [Internet]. Cdscoonline.gov.in. 2021 [cited 4 October 2021]
- Motilium tablets (Domperidone) [Internet]. Janssen.com. 2021 [cited 4 October 2021]
- Domperidone 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 4 October 2021]
- Domperidone 10mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 4 October 2021]
- MOTILIUM suppositories [Internet]. Mri.cts-mrp.eu. 2021 [cited 4 October 2021]
- Domperidone 1mg/ml Oral Suspension - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 4 October 2021]
- Domperidone 1mg/ml Oral Suspension - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 4 October 2021]