Dabigatran Etexilate

Uses	Anti-coagulant, blood thinner
Therapy	Anti-Coagulant
Side Effects	Bleeding or bruising, stomach ache, feeling sick, indigestion, loose motions, anaemia

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Molecule Description

Dabigatran Etexilate is an anticoagulant medicine. It is used to treat and prevent deep vein thrombosis (formation of blood clots in the deep vein of your body, usually your legs) and pulmonary embolism (blood clot in the blood vessels of the lungs). It is also used for the prevention of stroke, systemic embolism and reduction of vascular mortality in adult patients with atrial fibrillation. Dabigatran Etexilate works by preventing the formation of a blood clot. Do not stop taking this medicine or miss a dose of this medicine without talking to your doctor. Continue to take dabigatran even if you feel well. Make sure to refill your prescription before you run out of medication so that you will not miss a dose.

Uses

Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and prevention of related death.
To prevent recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE).
To prevent blood clots in the brain (stroke) and other blood vessels in the body if you have a form of irregular heart rhythm (atrial fibrillation).

Contraindications

When should one not use Dabigatran Etexilate

Known allergy to dabigatran etexilate or any of the other ingredients of Dabigatran Etexilate.

Side effects

Common side effects of this drug are:

Bleeding or bruising
Stomach ache
Feeling sick
Indigestion
Loose motions
Anaemia

Precautions and Warnings

Pregnancy

The effects of Dabigatran Etexilate on pregnancy and the growing child are not known. You should not take this medicine during pregnancy unless your doctor advises you that it is safe to do so. Women of childbearing age should avoid becoming pregnant while taking this medicine.

Breast Feeding

You should not breastfeed while taking Dabigatran Etexilate.

Driving

This medicine does not alter your driving abilities.

Alcohol

There is no known interaction between alcohol and Dabigatran Etexilate. Discuss it with your doctor if you drink too often. Heavy drinking while taking this medicine is dangerous and can increase the anticoagulant action of this medicine and make you more likely to bleed.

Other General Warnings

Talk to your doctor if

You have any bleeding disorder, bleeding in any part of your gut, ulcers, skin lesions.
You have had a surgical tissue removal (biopsy) in the past month.
You had an injury recently and still recovering from that (bone fracture, head injury or any injury requiring surgical treatment).
You have swelling or inflammation in the food pipe & stomach or stomach acid comes up to the food pipe.
Your kidneys and liver are not functioning properly.
Your weight is less than 50 kgs or you are an elderly person (+75 years).
You need to have an operation. You will be asked to stop taking this medicine for a while to avoid the risk of bleeding. Make sure you take Dabigatran Etexilate before and after the operation exactly at the times you have been told by your doctor.
You are going to undergo an operation that involves a catheter or injection into your spinal column.

Mode of Action

How Does It Work?

Dabigatran Etexilate works by inhibiting the action of an enzyme involved in the blood clotting and hence increases the clotting time.

Interactions

Interactions with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, supplements or herbals.
Certain medicines such as oral antifungals such as ketoconazole, cyclosporin (used to prevent organ rejection after transplantation), dronedarone (to treat abnormal heartbeat) and antiviral medicines such as glecaprevir and pibrentasvir should not be taken with Dabigatran Etexilate.
Concomitant use of tacrolimus (used during organ rejection) and Digoxin (used for heart conditions) is not recommended with Dabigatran Etexilate.
Caution to be exercised in case of concomitant use of certain medicines such as Verapamil (for high blood pressure), Amiodarone & Quinidine (used for heart conditions), Clarithromycin (an antibiotic) and Posaconazole (an antifungal).
Concomitant use of medicines such as rifampicin, carbamazepine or phenytoin should be avoided.
Other anticoagulants & antiplatelet agents if taken along with Dabigatran Etexilate may increase the risk of bleeding.

Interactions with food items

You can take Dabigatran Etexilate with or without food.

Dosage

Overdose

Taking too much of this medicine increases the risk of bleeding. In case of an overdose, contact your doctor immediately or reach out to the nearest hospital.

Missed a Dose

Take the forgotten dose as soon as you remember it. If it's already time for the next dose then skip the missed dose and follow the usual dosing schedule. You should never miss the dose of this medicine as it may lead to an increased risk of clot formation.

Frequently Asked Questions (FAQs)

Due to an increased risk of bleeding, you need to stop taking this medicine temporarily during and shortly after an operation. It is very important to take this medicine before and after the operation exactly at the times you have been told by your doctor.

You can take Dabigatran Etexilate with or without food.

Yes, Dabigatran Etexilate is a blood thinner, which acts by reducing blood clot formation.

Dabigatran Etexilate is generally prescribed for a long duration. However, it is advisable to take this medicine only as directed by your doctor. Do not take more of it and do not take it for a longer time than your doctor ordered.

Dabigatran Etexilate is an anticoagulant medicine that is used to prevent and treat blood clots in the brain (stroke) and other blood vessels in the body. It is also used to treat blood clots formed in the veins of your legs and lungs and prevent them from reoccurring.

You should take Dabigatran Etexilate at any time of the day as per the schedule prescribed by your doctor. But it's better to take it at the usual time daily. Taking it at the same time will reduce the chances of missing the dose and it will also help you to get optimum results.

Dabigatran Etexilate works within a few hours of taking it. However, it can vary among individuals depending on their physiology and other biological parameters.

Stomach ache, feeling sick, indigestion, loose motions, anaemia are a few common side effects of Dabigatran Etexilate. Bleeding can be serious. Seek medical help immediately if you notice unusual bleeding, black stools, blood in urine or a severe headache. Also, it is not important that everyone experience the same.

Dabigatran Etexilate is an anticoagulant medicine that is used to treat and prevent deep vein thrombosis (formation of blood clots in the deep vein of your body, usually your legs) and pulmonary embolism (blood clot in the blood vessels of the lungs).

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