Cyclophosphamide

Molecule Description

Cyclophosphamide is used to treat and prevent cancers in the body and also to s

uppress the immune system. It belongs to a class of medicines called ‘alkylating agents’

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Cyclophosphamide

Treatment of cancer of certain type of white blood cells (acute and chronic
lymphocytic leukemia)
As conditioning for bone marrow transplantation, in certain cancers of white blood
cells that start in the bone marrow (acute lymphoblastic, acute and chronic
myelogenous leukemia)
Cancer of immune white blood cells (plasma cells, a condition called multiple
myeloma), and cancer of the lymph nodes (glands of the immune system, conditions
called as hodgkin’s and non-hodgkin’s lymphoma)
Advanced cancers of the breast and the ovary (that are spreading)
‘Add-on’ treatment to other medicines for treatment of breast cancer (that is not
spreading)
A type of cancer of the soft tissues (muscles, tendons, ligaments etc) or the bones
(ewing’s sarcoma)
A type of lung cancer (small cell lung cancer)
Advanced cancer of immature nerve cells (neuroblastoma)
Life-threatening diseases of the immune system (lupus nephritis that affects the
kidney, a condition called wegener’s granulomatosis that affects the blood vessels)

Contraindications of Cyclophosphamide

When should one not use Cyclophosphamide

Allergy to cyclophosphamide or to any of the components
Any acute infections
Bone marrow depression or aplasia (severely reduced cells of the bone marrow)
Urinary tract infections, urinary outflow obstruction
Damage to the lining of the lower urinary tract (damaged urothelium of the urinary
tube between the kidney and outlet)
Cyclophosphamide should not be used for any conditions other than cancer except
for suppression of the immune system in life-threatening situations

Side effects of Cyclophosphamide

Common side effects of this drug are:

Decreased activity of the bone marrow causing (myelosuppression)
Decreased production of white blood cells (leucopenia, neutropenia)
Hair loss
Burning sensation and increased frequency of passing urine (cystitis)
Fever
Suppression of the immune system (increase in infections due to reduced resistance)
Irritation of lining of some organs (mucositis)
Blood in the urine (microhematuria)
Feeling unwell, weakness
Liver problems
Chills
Infertility in men
Low red blood cells and platelet counts (anemia and thrombocytopenia)
Lung infections (pneumonia), sepsis (wide spread infection), allergic reactions, chest
pain, fast heart beats, redness of skin, numbness, nerve pain, decreased hunger,
deafness, infertility in females (uncommon)
Allergic reactions with difficulty in breathing, high heart rate, low blood pressure,
tiredness, swelling of face and lips, rashes and itching (Anaphylactic reactions – rare,
but serious)

Precautions and Warnings of Cyclophosphamide

Pregnancy

Can I take Cyclophosphamide during pregnancy?

Do not use Cyclophosphamide if you are pregnant Cyclophosphamide might affect the unborn baby. Follow contraceptive measures while you are on this medicine. Inform your doctor if you are pregnant or planning pregnancy

Breast Feeding

Can I take Cyclophosphamide while breastfeeding?

Do not take cyclophosphamide if you are breastfeeding, as it appears in human milk in toxic amounts and can harm the baby. Please consult before taking this medicine if you are breastfeeding

Driving

Can I drive if I have consumed Cyclophosphamide?

Caution is recommended as Cyclophosphamide can cause side effects such as dizziness, vision problem after taking this medicine. Do not drive if you experience any of these symptoms

Alcohol

Can I consume alcohol with Cyclophosphamide?

Cyclophosphamide causes nausea and vomiting, if you drink alcohol while on this treatment increase the risk of nausea and vomiting It is important to note that alcohol delays healing in conditions like cancer

Other General Warnings

Talk to your doctor if

Low blood cell counts
Severe infections
Liver or kidney problems
Your adrenal glands (hormone releasing glands present on top of the kidney) have
been removed
Received treatment for cancer by radiation (radiotherapy) or by medicines
(chemotherapy)
Heart problems or radiation treatment in your chest area
Diabetes
Weak, elder or have poor oral health
Had recent surgery (less than 10 days ago)

Mode of Action of Cyclophosphamide

How Does It Work?

Cyclophosphamide acts by killing the cancer cells in the body after being activated in the liver. At lower doses, it suppresses certain regulatory (T-cells) cells of the immune system and causes immun...

Interactions of Cyclophosphamide

Interactions with other medicines

Medicines used to treat HIV/ AIDS (zidovudine, ritonavir, nelfinavir)
Medicines used to treat high blood pressure (ACE inhibitors – ramipril, enalapril,
lisinopril; diuretics – furosemide, torsemide)
Medicines used to treat immune disorders (natalizumab, azathioprine, cyclosporine,
etanercept)
Certain anti-cancer medicines (paclitaxel, anthracyclines, cytarabine, pentostatin,
trastuzumab, tamoxifen, radiation treatment of the chest region)
Medicines that increase the number of blood cells (CSF-colony stimulating factors)
Medicines used to treat heart disease (amiodarone)
Metronidazole (an antibiotic)
Muscle relaxants (succinyl choline etc)

Interactions with food items

No known food interaction with this medicine

Dietary Restrictions of Cyclophosphamide

Drink plenty of water and fluids to avoid any urinary complications while you are
taking Cyclophosphamide
Consumption of Grapefruit (fruit or juice) is not recommended while taking
Cyclophosphamide

Dosage of Cyclophosphamide

Overdose

Overdose leads to life threatening situations at very high doses You are advised to take this injection or infusion (slow drip into the veins) in a hospital setting under supervision This will minimiz...

Missed a Dose

Take the missed dose as soon as you remember If the missed dose falls at the time of you next scheduled dose then skip it Do not take a double dose to make up for the missed dose

Frequently Asked Questions (FAQs)

Q: Are there any special precautions I need to follow while taking cyclophosphamide?

A: Females should not try for pregnancy up to 12 months after discontinuing treatment with Cyclophosphamide Males on Cyclophosphamide should use birth control up to 6 months after stopping the treatment If you are of reproductive age, it may be advisable to preserve your sperms or eggs as Cyclophosphamide may irreversibly affect your fertility Cyclophosphamide interferes with wound healing Exercise caution and reduce the incidence of any cuts, injuries, burns etc and give immediate attention Cyclophosphamide can cause mouth ulcers and sore gums You are advised to maintain good oral health

Q: What else do I need to know while taking Cyclophosphamide?

A: White blood cell and platelet count need to be done regularly while on treatment with Cyclophosphamide If the medicine is given by infusion (slow drip) or by direct injection (through the veins), it has to be done by trained personnel You are advised not to do it on your own Infusion (slow drip into the veins) should be done over a period of 30 minutes to 2 hours

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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एक स्वस्थ जीवन जीने और वज़न कम करने के लिए हम अलग-अलग तरीकों और स्वास्थ्यवर्धक काढ़ों जैसी चीज़ें आज़माते रहते हैं। अनगिनत स्वास्थ्य लाभों का वादा करने के अलावा, ये शरीर को डिटॉक्स करने और वज़न घटाने में मदद करने का भी दावा करते हैं। लेकिन एक पेय (ड्रिंक) है जो ऐसा करने में कामयाब

मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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