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Clobazam

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Molecule Summary

Uses
Epilepsy/Seizures, Anxiety disorder, Sleeping disorders, Lennox-Gastaut Syndrome, Panic disorder (occurrence of unexpected panic attacks), Akinetic and Myoclonic Seizures
Therapy
Anti-Anxiety, Anti-Epileptic
Side Effects
Depression, Dizziness, Drowsiness, Impaired coordination, Memory impairment
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Molecule Description

Clobazam is a prescription medication. It belongs to the class of Benzodiazepine (also known as tranquillisers). It primarily treats epilepsy (a disorder that causes sudden and uncontrolled disruption in the electrical activity of the nerve cells in the brain). It is used to treat anxiety disorders (a mental illness associated with fear, anxiety, or excessive nervousness). The medicine is also used in treating panic attacks and relieving sleeping disorders. It works by decreasing the irregular electrical movements in the brain.

Uses

  • Clobazam is used in the following cases:
  • Epilepsy/Seizures
  • Anxiety disorder
  • Sleeping disorders
  • Lennox-Gastaut Syndrome
  • Panic Disorder (Occurrence of unexpected panic attacks)
  • Akinetic and myoclonic seizures

Contraindications

When should one not use Clobazam

  • If you have been diagnosed with acute narrow-angle glaucoma; this medicine can worsen the condition
  • If you are allergic to benzodiazepines or any component of Clobazam

Side effects

Common side effects of this drug are:

  • Clobazam may show the following side effects:
  • Depression
  • Dizziness
  • Drowsiness
  • Impaired coordination
  • Memory impairment

Precautions and Warnings

Pregnancy

Pregnancy

Using Clobazam during pregnancy is not recommended by healthcare professionals. Avoid taking this medication if you are pregnant, except when essential. The benefits must outweigh the possible risks in such a scenario. There are reported complications in newborn babies whose mothers took anti-seizure medicines. This medicine can harm the foetus as well.

Breast Feeding

Breast Feeding

The principal component of Clobazam is excreted in the breast milk of lactating mothers. This can cause adverse reactions in infants. Decide with your doctor if you should discontinue nursing or the treatment.

Driving

Driving

No. Clobazam can cause adverse effects like dizziness, unsteadiness, and balance issues, affecting your ability to drive, operate heavy machinery, or do any activity that requires concentration.

Alcohol

Alcohol

Avoid alcohol while taking Clobazam, as alcohol and other depressants such as narcotics can increase drowsiness and affect breathing.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You notice behavioural changes or have suicidal thoughts after starting treatment with this medicine.
  • You have a history of heart, kidney, or liver issues.
  • You take medicines or supplements (herbal, Ayurvedic, or otherwise) for any other medical condition.

Mode of Action

How Does It Work?

Clobazam belongs to a class of medications known as Benzodiazepine. It works by increasing the action of a chemical messenger, gamma-aminobutyric acid (GABA), at the GABA A receptor, which subdues the abnormal activity of the nerve cells in the brain. It also has an agent that controls seizures or anti-panic effects. It improves the activity of GABA and suppresses the spike and waves discharge in the absence of seizures. This decreases the frequency, amplitude, and duration of minor motor seizures and controls the onset of seizures in epileptic patients. Clobazam calms the nerve cells and helps in reducing anxiety and inducing sleep.

Interactions

Interactions with other medicines

  • Clobazam belongs to a class of medications known as Benzodiazepines. Clobazam can interact with any of these medicines:
  • Abacavir (A severe interaction may be seen as Abacavir can augment the blood level of Clobazam.)
  • Adefovir (A severe interaction may be seen as Adefovir can increase the blood level of Clobazam.)
  • Carbamazepine (This is an anticonvulsant medication used mainly to treat epilepsy and neuropathic discomfort. It may interact severely with Clobazam.)

Dosage

Overdose

Clobazam overdose can lead to symptoms like seizure, collapse, troubled breathing, and irregular heartbeat. If you overdose on Clobazam and experience any of these symptoms, immediately seek emergency medical treatment from a hospital close to you.

Missed a Dose

If you have missed a dose of Clobazam, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue with your regular dosing schedule. Do not take both of them together; this can lead to adverse reactions.

Frequently Asked Questions (FAQs)

Yes; Clobazam is a prescription medicine. No one else should consume your medication. Ask the doctor questions that you might have about the prescription. You should keep a written list of all the current prescription medications. Take a prescription with you every time you visit a doctor or in case you are admitted to the hospital. It is vital information that must be known in an emergency.

If Clobazam is taken in the dose and duration prescribed by the doctor, it should not be habit-forming. Your healthcare provider may change the dose of the medicine till it is perfect for you.

The time taken to feel better varies from person to person. Take Clobazam exactly as prescribed by your doctor.

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