Cilostazol / Cilostazole

Uses	Intermittent claudication (pain in the legs)
Therapy	Vasodilating Agent
Side Effects	Vomiting, nausea, headache, dizziness

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Molecule Description

Cilostazol / Cilostazole is used for the treatment of cramp-like pain in the legs due to decreased blood supply (intermittent claudication). Do not take this medicine if you are having a history of allergy, any heart problems like chest pain or abnormal heart rhythm, bleeding problems, kidney or liver problems and in pregnancy or breastfeeding. Do not take this medicine with any other medicines which increases the chances of bleeding. Take immediate medical attention if you feel chest pain that radiates to the shoulder or back. It should not be used in children.

Uses

Cilostazol / Cilostazole is used for the treatment of cramping pain in the legs during walking due to insufficient blood supply in the legs (intermittent claudication).

Contraindications

When should one not use Cilostazol / Cilostazole

If you are allergic to cilostazol or any other ingredients of Cilostazol / Cilostazole.
If you have any kidney or liver problems.
If you have any heart-related disorders such as heart attack or abnormal heart rhythm.
If you have any condition which may increase the chances of bleeding or bruising like, stomach ulcers, history of stroke in the last six months, eye problems associated with diabetes, uncontrolled blood pressure.
If you are taking medicines like Aspirin and Clopidogrel or any other medicines which may increase the risk of bleeding.
If you are suffering from chest pain, heart attack currently or in the last 6 months.
Pregnant women should not take Cilostazol / Cilostazole.

Side effects

Common side effects of this drug are:

Vomiting
Nausea
Headache
Diarrhoea
Indigestion
Flatulence
Abdominal pain
Rashes
Dizziness
Chest pain
Weakness

Precautions and Warnings

Pregnancy

Limited information is available on the use of this medicine during pregnancy. The use of this medicine during pregnancy is not recommended.

Breast Feeding

The use of Cilostazol / Cilostazole is not recommended during breastfeeding as the component of this medicine passes into breastmilk.

Driving

This medicine may cause dizziness, headache, tiredness or feel sick. So, do not drive or use machinery if you are taking this medicine.

Alcohol

The chances of dizziness increases if you take this medicine with alcohol. Even alcohol adds on the side effects related to the liver with concomitant use of this medicine. So, avoid using this medicine with alcohol.

Other General Warnings

Talk to your doctor if

You have any heart problems or heart rhythm abnormalities.
You have any problems related to blood pressure.
You need any surgery like teeth removal during Cilostazol / Cilostazole treatment, inform your dentist.
You show symptoms like easy bruising, bleeding, fever or sore throat.
Cilostazol / Cilostazole is not suitable for children and adolescents.

Mode of Action

How Does It Work?

Cilostazol improves the blood flow and circulation in the legs. So, patients can walk more distance without pain. It is recommended in patients whose symptoms can't be improved with lifestyle modification like increasing exercise or smoking cessation. Your doctor may advise you to continue those lifestyle changes along with this medicine for better results.

Interactions

Interactions with other medicines

Some medicines can affect the way Cilostazol / Cilostazole works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
Concomitant use of this medicine with blood thinners with this medicine may increase the risk of side effects.
This medicine should not be used with any other blood pressure lowering medications as it can lower the blood pressure and result in undesirable effects.
The effect of this medicine increases when used together with medicines to lower acidity such as Omeprazole. This may increase the risk of side effects associated with Cilostazol / Cilostazole.
It is important to inform the doctor about all the medication and herbal supplements consumed before using this medicine.

Interactions with food items

Large amounts of grapefruit juice along with this medicine may reduce its effect.

Dosage

Overdose

Symptoms of an overdose of Cilostazol / Cilostazole may increase the side effect of medicine. You may feel severe headache, diarrhoea, increase in heart rate, and irregularities of your heartbeats. Seek immediate medical attention if you take too much of this medicine.

Missed a Dose

If you have missed taking any dose of Cilostazol / Cilostazole, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

This combination may decrease the blood pressure too low and produce symptoms like chest pain, abnormal fast heartbeats and sometimes heart attack or stroke. So, always tell your doctor beforehand if you are using any other blood pressure lowering medicines.

Cilostazol / Cilostazole inhibits the enzyme phosphodiesterase type 3 in the body. Thus, improves the blood flow and circulation in the legs. So, patients can walk more distance without pain. It is useful in patients with intermittent claudication.

No, Smoking decreases the effectiveness of Cilostazol / Cilostazole. Even smoking worsens the symptoms related to intermittent claudication, so avoid smoking during therapy.

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