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Bisoprolol Fumarate+Amlodipine

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Molecule Summary

Uses
High blood pressure
Therapy
Anti-Hypertensive
Side Effects
Dizziness, headache, blurring of vision, increased heart beats
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Molecule Description

Bisoprolol Fumarate+Amlodipine is used in the treatment of high blood pressure. It is a combination medicine containing bisoprolol and amlodipine. Take this medicine in doses and duration as suggested by the doctor. It should not be stopped without a doctor's advice. Inform your doctor if you recently had a heart attack or are suffering from heart failure or any other medical condition. Never stop taking this medicine on your own, even if you start feeling better. Tell your doctor beforehand about any other medicines you are taking.

Uses

It is used in the treatment of high blood pressure.

Contraindications

When should one not use Bisoprolol Fumarate+Amlodipine

  • If you are allergic to bisoprolol and amlodipine or any other ingredients of Bisoprolol Fumarate+Amlodipine.
  • If you experience Shock related to the heart (a condition where the body is not getting enough blood).
  • If you have any heart-pumping outflow obstruction.
  • If you have a history of unstable heart failure (pumping problem of the heart may occur after heart attack).
  • If you have a history of Atrioventricular block (AV block) (type of heart block that occurs when the electrical signal travelling from the upper chambers of the heart to the lower chambers of the heart, is impaired).
  • If you have a very slow heart rate or severe asthma.
  • If you are experiencing severe blood circulation problems in your limbs (such as Raynaud's syndrome), which may cause your fingers and toes to tingle or turn pale or blue.
  • If you have a tumour of the adrenal gland (pheochromocytoma).
  • If you have metabolic acidosis (Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance).

Side effects

Common side effects of this drug are:

  • Diarrhoea
  • Nausea
  • Dyspepsia
  • Dizziness
  • Headache
  • Blurring of vision
  • Increased heartbeats
  • Hot flushes
  • Abdominal pain
  • Constipation
  • Swelling around the ankles
  • Weakness
  • Muscle cramps

Precautions and Warnings

Pregnancy

Pregnancy

The components of this medicine pass into the blood of the baby and may adversely affect your baby. So it is advisable to not use this medicine if you are pregnant or planning to have a baby. If you become pregnant stop using this medicine and consult your doctor immediately.

Breast Feeding

Breast Feeding

Limited information is available on the use of Bisoprolol Fumarate+Amlodipine in breastfeeding mothers. Use while breastfeeding is not recommended.

Driving

Driving

This medicine may cause dizziness, headaches, and tiredness. Any of these side effects would reduce your ability to react. So, do not drive or use machinery if you are taking this medicine.

Alcohol

Alcohol

Chances of dizziness increases if you take this medicine with alcohol. Even alcohol adds on the side effects related to the liver with concomitant use of this medicine. So avoid using this medicine with alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have kidney or liver disease.
  • You have experienced a recent heart attack.
  • You have the tendency of heart failure (pumping problem).
  • You have diabetes, you are an elderly patient or have any thyroid disorder.
  • You suffer from a severe increase in blood pressure (hypertensive crisis).
  • You follow strict fasting (fasting from solid food).
  • You have certain heart diseases such as disturbance in heart rhythm or severe chest pain at rest (Prinzmetal's angina).
  • Blood circulation problem in your limbs.
  • You have asthma or chronic lung disease.
  • You have a history of a scaly skin rash (psoriasis).
  • You have a tumour of the adrenal gland (medulla) (pheochromocytoma).
  • Also, tell your doctor if you are going to have Desensitization therapy or any surgery.

Mode of Action

How Does It Work?

Amlodipine blocks the calcium channels present in the blood vessels, which relaxes the blood vessels and decreases the blood pressure. Bisoprolol decreases the rate of pumping of the heart and decreases blood pressure.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Bisoprolol Fumarate+Amlodipine works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Especially if you are taking medicines for fungal infection, HIV infection, medicines for heart disease, antibiotic medicines, painkillers and medicines for asthma.

Interactions with food items

  • Grapefruit juice and grapefruit should not be consumed by people who are taking Bisoprolol Fumarate+Amlodipine.

Dosage

Overdose

Overdose may increase the side effects of this medicine. Symptoms of overdose may include dizziness, lightheadedness, fainting or feeling weak. If a blood pressure drop is severe enough shock can occur. Your skin could feel cool and clammy and you could lose consciousness. Slow heartbeat, severe breathing difficulties can occur. Seek immediate medical attention if you take too much of this medicine.

Missed a Dose

In case you've missed any dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Avoid taking a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Bisoprolol Fumarate+Amlodipine contains two active components Bisoprolol and Amlodipine. This combination of medicine is used for treating high blood pressure, especially if it is not controlled by single medicine.

Do not stop this medicine abruptly or without a doctor's advice. Sudden stoppage of this medicine may increase the chances of returning of symptoms or it may flare-up.

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