Benidipine

Uses	High Blood Pressure (Hypertension) and Angina Pectoris (Chest Pain)
Therapy	Anti-Hypertensive
Side Effects	Tiredness, Swelling of the Ankles, Drowsiness, Flushing (Sense of Warmth in the Face, Ears, Neck and Trunk), Headache, Dizziness, Palpitations

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NPPA
Regulated

Molecule Description

Benidipine is a calcium channel blocker. Large vessel stiffness is one of the leading causes of elevated blood pressure in individuals. As a result, Benidipine is used to decrease blood pressure by relaxing the blood vessels. Benidipine is also used to alter the heart rate, which will reduce chest pain by allowing more blood to flow to the heart muscle.

Uses

Management of High blood pressure levels in the body
Chest pain caused by coronary artery disease, known as angina pectoris
Treatment of diabetic kidney disease with hypertension

Contraindications

When should one not use Benidipine

Allergies to compounds of Benidipine
Liver impairment: Make appropriate adjustments in dosage or find alternatives if suffering from liver-related issues
Hypotension: May cause a lowering of blood pressure for those already suffering from low blood pressure

Side effects

Common side effects of this drug are:

Vertigo
Headache
Flushing
Dizziness
Vomiting
Orthostatic hypotension (a sudden decrease in systolic or diastolic blood pressure on standing after a prolonged sitting position)
Palpitations
Renal impairment
Anaemia
Increased potassium in blood

Precautions and Warnings

Pregnancy

The medication is not recommendable for use in pregnant women, except in some cases where it is crucial. Discuss the risks and benefits with the doctor before consumption.

Breast Feeding

Breastfeeding women must not consume Benidipine since it may affect the infant.

Driving

In specific individuals, Benidipine may cause dizziness. Driving while suffering from such side effects must be avoided.

Alcohol

Consuming alcohol while taking this medication may lead to certain unwanted side effects such as light-headedness, dizziness, and drowsiness.

Other General Warnings

Talk to your doctor if

You are suffering from severe renal impairment
Go through the medications you are currently taking with your doctor before having this medicine
Follow your doctor’s directions to take the medicine
Inform your doctor about any pre-existing medical conditions before taking the medicine
Avoid excessive dosage, and take exactly as much as your doctor has recommended

Mode of Action

How Does It Work?

It is a long-acting calcium channel blocker class of medicine which are used to treat hypertension. By blocking the influx of Ca ions through voltage-gated L-type Ca channels to the peripheral vascular smooth muscle cells, coronary smooth muscle cells and the myocardial cells causes dilatation of vascular endothelium, decrease peripheral resistance and reduce myocardial oxygen demand. It markedly relax arterioles and milder effects on veins, decrease afterload, and increase cardiac index.

Interactions

Interactions with other medicines

Beta-blockers: Potentiate the antihypertensive effect of Benidipine
Diuretics: Potentiate the antihypertensive effect of Benidipine
Digoxin: It can increase the serum concentration of Digoxin
Cimetidine: Inhibit the metabolism of Benidipine

Interactions with food items

Taking this medicine with grapefruit juice may decrease the blood pressure excessively
Taking this medicine with ginseng increases blood pressure and reduces the effect of benidipine

Dosage

Overdose

Overdosing on Benidipine may have severe health consequences. Consuming more of the medication or overdosing will not help with faster recovery. It may lead to worsening of the side effects such as dizziness and fatigue.

Missed a Dose

If you have missed a dose, and it is time for the next dose, skip the missed one
Do not overdose to make up for the missed dose
Exercise caution while consuming the medication, and visit a doctor immediately in case of an overdose

Frequently Asked Questions (FAQs)

Yes, Benidipine is the form of the generic medicine that is available. It is also available under several other brand names.

Typically, you will be able to see the medicine in effect within an hour of consumption. It has been shown to reach a maximum concentration within 2 hours from the time you consumed Benidipine.

It is necessary to be cautious for those suffering from renal impairment.

The liver almost entirely metabolizes Benidipine. Benidipine can primarily be distributed to the tissues in the kidneys, plasma and liver.