Artesunate+Sulfadoxine+Pyrimethamine

Uses	Acute Malaria
Therapy	Anti-Malarial
Side Effects	Headache, Dizziness, Myalgia, Anorexia, Arthralgia

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Molecule Description

Artesunate+Sulfadoxine+Pyrimethamine consists of sulfadoxine, pyrimethamine and artesunate and is indicated for the treatment of malaria.

Uses

Malaria

Contraindications

When should one not use Artesunate+Sulfadoxine+Pyrimethamine

Hypersensitivity to any of the three medicines in this product
Sulfonamide allergy or intolerance
Megaloblastic anaemia
Severe impairment of kidney or liver function

Side effects

Common side effects of this drug are:

Headache
Dizziness
Vertigo
Anaemia
Myalgia (muscle pain)

Precautions and Warnings

Pregnancy

Artesunate+Sulfadoxine+Pyrimethamine is contraindicated in pregnancy as it is toxic to the growing baby.

Breast Feeding

Artesunate+Sulfadoxine+Pyrimethamine can cross via breast milk to the baby, but no side effects are expected. The doctor can assess the risk-benefit ratio. Please consult your doctor.

Driving

The medication may cause side effects like dizziness and blurred vision; you shouldn't drive after taking this medication.

Alcohol

No data is available for alcohol and this medication.

Other General Warnings

Talk to your doctor if

You have allergies
You have anaemia
You have liver disease
You have kidney disease

Mode of Action

How Does It Work?

Artesunate+Sulfadoxine+Pyrimethamine works on three mechanisms; sulfadoxine is an antibiotic that stops the malaria parasite multiplication. Pyrimethamine is an antiparasitic that prevents the formation of malarial cell, whereas artesunate acts by causing cell death.

Dosage

Overdose

Headaches, vomiting, agitation, convulsions, and haematological changes can be seen. After intoxication, your doctor might treat you with activated charcoal and with adequate fluid administration. Seek immediate medical help.

Missed a Dose

If the dose is missed, the medication should be taken as soon as possible. Make sure you have the proper time interval between two doses. If the time interval is near the second dose, skip the previous dose and follow the regular schedule.

Frequently Asked Questions (FAQs)

Consult your doctor before giving Artesunate+Sulfadoxine+Pyrimethamine to a child. Your doctor will decide whether it is suitable and the right dose for your child.

Artesunate+Sulfadoxine+Pyrimethamine has to be used till the duration specified by your doctor. It is necessary to complete the regimen.

Artesunate+Sulfadoxine+Pyrimethamine does not show any reactions with patients with heart conditions; however, proper monitoring is required for such patients.

You should give a brief medical history to your doctor, about any underlying diseases such as anaemia, hypertension or any cardiovascular disorder.

Tell your doctor about all medicines or supplements you are currently taking. Tell your doctor if planning for pregnancy.

Artesunate+Sulfadoxine+Pyrimethamine treatment should be followed and completed as prescribed by the doctor. The regimen given prevents recurrent disease and treats the infection completely; hence, do not stop the treatment if you are asymptomatic.