Apremilast
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Molecule Summary
| Uses | Psoriatic arthritis, chronic plaque psoriasis |
| Therapy | Drugs For Psoriasis |
| Side Effects | Diarrhoea, nausea, cough, vomiting, indigestion, back pain, feeling tired, stomach pain, headache, loss of appetite, difficulty in sleeping |
Medicines
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19k pincodes
Molecule Description
Apremilast is used to treat psoriatic arthritis and some moderate to severe skin conditions. This medicine reduces inflammation and redness, thus provides relief from the condition. Take this medicine as advised by your doctor for the prescribed duration. Inform your doctor if you are pregnant or planning pregnancy and if you are on any medications or supplements.
Uses
- Apremilast is used to treat psoriatic arthritis (It is a type of arthritis that affects some people who have psoriasis, symptoms include red patches and scaly skin).
- It is also useful in treating moderate to severe skin conditions (chronic plaque psoriasis).
Contraindications
When should one not use Apremilast
- If you are allergic to apremilast or any other ingredient of Apremilast.
- If you are pregnant or think you may be pregnant.
Side effects
Common side effects of this drug are:
- Diarrhoea
- Nausea
- Cough
- Vomiting
- Indigestion
- Back pain
- Feeling tired
- Stomach pain
- Headache
- Loss of appetite
- Difficulty in sleeping
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You are suffering from severe kidney problems. Your doctor may reduce the dose.
- You are underweight.
- You have problems with your gut.
- You experience diarrhoea, nausea, or vomiting. Apremilast should be stopped quickly and you should visit your doctor.
- You feel any changes in behaviour or mood, sleeplessness, or depressive mood.
- Apremilast is not recommended for patients below the age of 17 years
Mode of Action
How Does It Work?
Apremilast subdues the activity of an enzyme in the body called 'Phosphodiesterase 4', which is responsible for inflammation or reaction that creates redness, swelling, pain and warmth and irritation. Thus, it helps in reducing the inflammation.
Interactions
Interactions with other medicines
- Apremilast is not recommended with medicines such as rifampicin to treat tuberculosis, phenytoin, phenobarbital and carbamazepine to treat fits or epilepsy, St John's Wort herbal medicine for psychiatric illness.
- Some medicines can affect the way Apremilast works or Apremilast itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
Dosage
Overdose
Symptoms of overdose are usually the same as adverse effects. If you think you have taken excessive dosage of Apremilast and experience any of such signs, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed any dose of Apremilast, take it as soon as you remember. If it's time for your next dose then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate the missed one.
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