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Amoxapine

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Molecule Summary

Uses
Depression
Therapy
Anti-Depressant
Side Effects
Dry mouth, constipation, blurred vision, drowsiness, fluctuations in weight
3 Step Quality
Assurance
Cash on delivery
available
NPPA
Regulated

Molecule Description

Amoxapine uses include treatment of symptoms of depression. Amoxapine is a tricyclic antidepressant. Amoxapine belongs to the category of medicines called dibenzoxazepines. Amoxapine works quickly and has a mild sedative effect. Amoxapine works by restoring the balance of natural chemicals in the brain.

Uses

  • Amoxapine is used to treat symptoms of depression accompanied by agitation or anxiety.

Contraindications

When should one not use Amoxapine

  • If you are recovering from a heart attack
  • If you are allergic to amoxapine
  • If you are taking an MAO inhibitor

Side effects

Common side effects of this drug are:

  • Dry mouth
  • Constipation
  • Blurred vision
  • Drowsiness
  • Fluctuations in weight

Precautions and Warnings

Pregnancy

Pregnancy

Amoxapine should be used during pregnancy only if your doctor feels that the benefits outweigh the risks. Infants born to mothers who consume Amoxapine during pregnancy may experience problems like deep sleep, tremors, seizures and trouble urinating.

Breast Feeding

Breast Feeding

Amoxapine passes into the breastmilk. Its effects on breastfed infants have still not been studied. Your doctor will decide after assessing the risks and benefits of using Amoxapine.

Driving

Driving

Amoxapine can cause side effects like blurred vision and drowsiness. These make driving unsafe while taking Amoxapine.

Alcohol

Alcohol

Consuming alcohol with Amoxapine can aggravate side effects like dizziness and drowsiness.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You take other medicines, herbal supplements, nutritional supplements or vitamins
  • You are scheduled to undergo any surgery.
  • You are scheduled to undergo any pathological tests.
  • You get thoughts about suicide or self-harm while taking Amoxapine.
  • You notice any changes in your mood or behaviour while taking Amoxapine.
  • You have any other type of cardiac illness.
  • You have kidney problems.
  • You have glaucoma.
  • You have schizophrenia or any other form of mental disorder.
  • You have bipolar disorder.
  • You have problems with passing urine.
  • You have diabetes.
  • You are receiving electroconvulsive therapy.
  • Your age is less than 18.
  • You have any doubts, fears and apprehensions before starting treatment with Amoxapine.
  • Your side effects or symptoms become worse during treatment with Amoxapine.

Mode of Action

How Does It Work?

Norepinephrine, serotonin and dopamine are substances produced naturally in our system. These substances play a vital role in our mood and behaviour. Any imbalance in these substances can create changes in our mood and behaviour. Amoxapine reduces the uptake of norepinephrine and serotonin. Amoxapine also blocks the response of dopamine receptors to dopamine. All this maintains a proper balance between norepinephrine, serotonin and dopamine. This gives a feeling of well being to the patient. As some of amoxapine's effects are similar to tranquillisers, Amoxapine works better in patients who have agitation or anxiety along with depression.

Interactions

Interactions with other medicines

  • Amoxapine may interact with medicines like
  • Selective serotonin reuptake inhibitors(SSRIs), such as Citalopram, Escitalopram, Fluoxetine. Taking Amoxapine with medicines like citalopram, escitalopram and fluoxetine will put you at risk of serotonin syndrome. This rare but serious condition is characterised by fluctuation in blood pressure, hallucinations, shivering, tremors and diarrhoea.
  • Anti-anxiety medicines like Alprazolam, Lorazepam. Consuming Amoxapine with alprazolam and lorazepam can aggravate side effects like difficulty concentrating, drowsiness, dizziness and confusion.
  • Antihistamines like Cetirizine, Diphenhydramine. Combining Amoxapine with medicines like cetirizine and diphenhydramine can cause intense side effects like dry mouth, heat intolerance, constipation, confusion and irregular heartbeat.
  • MAO inhibitors like Isocarboxazid, Linezolid, Methylene blue. Taking Amoxapine with isocarboxazid, linezolid, and methylene blue can cause serotonin syndrome. This causes increased heart rate, excess sweating, fever, shivering, stomach cramps and blurred vision.

Interactions with food items

  • Amoxapine has no major interactions with food.

Dosage

Overdose

Contact your doctor if you have taken an overdose of Amoxapine. You may suffer from seizures, delirium, unconsciousness and even death.

Missed a Dose

If you miss a dose of Amoxapine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose of Amoxapine and continue with your regular schedule. Take Amoxapine at the same time daily to avoid missing doses.

Frequently Asked Questions (FAQs)

In rare cases, Amoxapine may increase the level of prolactin in your body. This may cause some problems in conceiving. Talk to your doctor if you are planning to start a family.

The effect of Amoxapine differs from person to person. It can take up to three weeks for Amoxapine to show its full effect. Talk to your doctor if you do not notice any improvement after that.

No. Suddenly stopping Amoxapine can make your depression symptoms worse. Your doctor will reduce your dose gradually before stopping it.

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