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Amisulpride

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Molecule Summary

Uses
Schizophrenia
Therapy
Anti-Psychotics
Side Effects
Nausea, Dizziness, Blurred vision, Constipation, Increased saliva secretion, Weight gain, Tremors
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Molecule Description

Amisulpride is used for the treatment of schizophrenia. Schizophrenia is a mental health condition characterised by hallucinations, delusions, extremely disordered thinking and behaviour, impairing daily functioning and disabling. Amisulpride helps stabilise symptoms like irritability, anxiety, and other behaviours in people suffering from schizophrenia.

Uses

  • As per CDSCO, Amisulpride is used in the treatment of acute and chronic schizophrenic disorders.

Contraindications

When should one not use Amisulpride

  • If you are allergic to components of Amisulpride.
  • If you are already on other antipsychotic medication.
  • If you are taking anti-Parkinson's medicine Levodopa.
  • If you have breast cancer or a family history of breast cancer. This medicine can increase prolactin (hormone) levels in the body.
  • If you have Parkinson's disease or dementia.
  • If you have an adrenal gland tumour, this medicine can cause life-threatening high blood pressure.
  • If you are pregnant or planning for it.

Side effects

Common side effects of this drug are:

  • Nausea
  • Dizziness
  • Blurred vision
  • Constipation
  • Increased saliva secretion
  • Weight gain
  • Tremors

Precautions and Warnings

Pregnancy

Pregnancy

No, Amisulpride is unsafe during pregnancy. Some research studies have shown a definite risk to unborn babies. Sometimes your doctor may prescribe this medicine during serious conditions if they think the benefits outweigh the risks. Do not take Amisulpride without consulting your doctor.

Breast Feeding

Breast Feeding

Amisulpride can be unsafe during breastfeeding. It may get excreted into breast milk and can affect the baby. Your doctor may advise you to discontinue breastfeeding for a while or prescribe low doses if you continue breastfeeding. Discuss the potential risks and benefits with your doctor.

Driving

Driving

Amisulpride may cause side effects that could affect your driving ability. The medicine may decrease alertness, affect your vision, and cause dizziness, lethargy, and lightheadedness. Do not drive if you are experiencing these side effects after taking this medicine.

Alcohol

Alcohol

It is advised to avoid alcohol consumption with Amisulpride as it may increase the risk of drowsiness and other side effects.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have any allergic reactions after taking Amisulpride.
  • You have any suicidal ideation or self-harming thoughts.
  • You experience severe changes in thought, behaviour or mood.
  • You notice a sudden decrease or loss of vision.
  • Your symptoms do not improve, or there is worsening of your condition.
  • You have a history of mild or severe liver or kidney conditions; this medicine may need a dose adjustment.
  • You have withdrawal symptoms like agitation, nausea, tremor, sweating and confusion.
  • You are using any ayurvedic or herbal medicines, vitamins and other health supplements.
  • You have respiratory issues.

Mode of Action

How Does It Work?

It acts by increasing dopamine and serotonin activity by blocking their receptors. These are chemical substances responsible for mood, ability, and cognitive behaviour. By blocking these receptors, the effect of these substances lasts longer, which helps in improving the various symptoms of psychological and mental disorders.

Interactions

Interactions with other medicines

  • Anxiety meds, such as diazepam, clonazepam, chlordiazepoxide, alprazolam and lorazepam. You may experience sedation and drowsiness.
  • Blood pressure-lowering medicine, such as amlodipine, lisinopril, losartan, or metoprolol. You may have low blood pressure.
  • Pain killers, such as morphine, oxycodone, fentanyl, hydrocodone, tramadol, and codeine. Interaction may cause more sedation and drowsiness.
  • Anti-Parkinson medicines such as levodopa. Taking this medicine with Levodopa for Parkinson's disease is not recommended, as they have exactly opposite effects.
  • Interaction with Antifungal medications like itraconazole and ketoconazole can reduce its effects.
  • Interaction with Antidepressants or mood-elevating medicines like fluoxetine and desipramine can cause increased side effects.
  • Interaction with other sedatives, heart medicines, antimalarial medicines, antihistamines, etc. All these medications can cause interactions.

Interactions with food items

  • You can continue with the regular diet as food doesn't influence the effect of Amisulpride.

Dosage

Overdose

An overdose of Amisulpride can cause dizziness, agitation, confusion, tremors, convulsion, nausea, vomiting, sleep disturbances, hypotension, increased heart rate, diminished reflexes, and coma. If you experience any of these symptoms or overdose on this medicine, immediately seek emergency medical treatment from a nearby hospital.

Missed a Dose

If you've missed a dose of Amisulpride, take it as soon as possible. If you remember missing a dose when it's already time to take the next scheduled dose, then skip the missed dose and take the next scheduled dose. Talk to your doctor if you have any confusion regarding this issue. Do not take both doses together as it can cause overdose side effects.

Frequently Asked Questions (FAQs)

Use Amisulpride for depression or any other mood disorder only if it is prescribed by your doctor. Do not start or stop it without consulting your doctor.

Amisulpride may cause weight gain. Eat healthily and exercise regularly to avoid any weight changes.

No, suddenly stopping the consumption of Amisulpride causes withdrawal symptoms which includes diarrhoea, vomiting, sweating, confusion, depression, nervousness and irritability. Consult your doctor before stopping the consumption of Amisulpride as doses need to be tapered slowly to avoid undesirable side effects.

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