Phenobarbital+Phenytoin

Uses	Epilepsy (fits), Trigeminal neuralgia (facial nerve pain), Anxiety, Sleep problems, High bilirubin levels in newborn, Drug withdrawal
Therapy	Anti-Epileptic
Side Effects	Nausea, Vomiting, Drowsiness, Dizziness, Headache, Nystagmus (involuntary eye movement), Vertigo.

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Molecule Description

Phenobarbital+Phenytoin belongs to the class of neurological medications known as 'anticonvulsants or antiepileptic medicines'. Phenobarbital+Phenytoin combines two ingredients (phenobarbitone and phenytoin) to treat and prevent seizures (epilepsy). Epilepsy is a central nervous system condition characterised by a sudden surge of electrical activity in the brain that causes seizures, fits, strange behaviour, and loss of consciousness. Uses of Phenobarbital+Phenytoin include preventing seizures by reducing abnormal and excessive brain nerve cell activity.

Uses

Epilepsy (fits)
Trigeminal neuralgia (facial nerve pain)
Anxiety
Sleep problems
High bilirubin levels in newborn
Drug withdrawal

Contraindications

When should one not use Phenobarbital+Phenytoin

If you have allergy/ hypersensitivity to barbiturates

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Drowsiness
Dizziness
Headache
Nystagmus (involuntary eye movement)
Vertigo

Precautions and Warnings

Pregnancy

Phenobarbital+Phenytoin should not be used during pregnancy because there is clear evidence that it harms the growing infant. However, in some life-threatening instances where the advantages outweigh the hazards, the doctor may prescribe it. Please consult with your doctor about the same.

Breast Feeding

Phenobarbital+Phenytoin should not be taken while breastfeeding. According to limited human research, the medicine may get transferred into the breastmilk and harm the baby. Besides, excessive drowsiness and weight growth should be closely monitored in the baby.

Driving

Phenobarbital+Phenytoin may cause side effects that could affect your ability to drive. The medicine may decrease alertness, affect your vision and make you feel dizzy and lightheaded. Do not drive if you are experiencing side effects after taking Phenobarbital+Phenytoin.

Alcohol

No, you must avoid consuming alcohol as it may increase the risk of side effects.

Other General Warnings

Talk to your doctor if

You are pregnant, planning to become pregnant, or breastfeeding before taking Phenobarbital+Phenytoin.
You're taking any prescription and over-the-counter medicines.
You have any liver illnesses. Phenobarbital+Phenytoin should be used with caution, and its dosage may need to be adjusted. Please seek medical advice.
You notice an increase in blood sugar levels. It is essential to regularly monitor your blood sugar levels and notify your doctor if you notice any changes.
You miss doses of Phenobarbital+Phenytoin. Missed doses might cause a seizure.

Mode of Action

How Does It Work?

Phenobarbital+Phenytoin is made up of two antiepileptic/anticonvulsant medicines: phenobarbitone and phenytoin. Phenobarbitone is an anticonvulsant and hypnotic barbiturate. It boosts GABA activity (gamma-aminobutyric acid), a chemical messenger in the brain. GABA helps to lessen the abnormal brain activity that happens during a seizure.

Interactions

Interactions with other medicines

You must inform your doctor about all prescription and non-prescription medications, herbal products, vitamins and nutritional supplements you are taking or plan to take before using Phenobarbital+Phenytoin.
The following medicines may interact with Phenobarbital+Phenytoin to exaggerate side effects and lead to severe complications.
Anti-inflammatory drugs like azapropazone
Medicines used to treat heart conditions such as dofetilide
Cholesterol-lowering agents such as colesevelam
HIV medications such as etravirine, delavirdine and rilpivirine
Blood pressure-lowering medicines like nisoldipine
Antipsychotics such as molindone
Antifungals such as itraconazole
Anti-ulcer drugs like sucralfate.

Interactions with food items

Food doesn't influence the effect of Phenobarbital+Phenytoin. Talk to your doctor about any supplements or herbal drinks you are currently taking before taking Phenobarbital+Phenytoin.

Dosage

Overdose

Overdose of Phenobarbital+Phenytoin can cause poisoning or serious side effects. It can cause symptoms like loss of coordination, headaches, irregular heartbeats, feeling lightheaded, fainting, and shallow breath. If you think you have taken an overdose, seek emergency medical treatment or contact the doctor immediately.

Missed a Dose

If you miss a dose, take a dose of Phenobarbital+Phenytoin as soon as possible. If your next dose is approaching, skip the missed dose and return to your regular schedule. Do not take two doses at the same time.

Frequently Asked Questions (FAQs)

Please don't stop taking Phenobarbital+Phenytoin without consulting your doctor since this could result in even more seizures. Take the medicine as directed by your doctor. If you have any problems while consuming Phenobarbital+Phenytoin, do not hesitate to contact your doctor.

Phenobarbital+Phenytoin contains phenytoin, which can reduce the effectiveness of birth control pills. Talk to your doctor about using non-hormonal contraceptives such as condoms and diaphragms with spermicide to prevent chances of pregnancy.

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