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Molecule Description

Domperidone+Pantoprazole is a combination medicine. It is used for the treatmen

t of gastrointestinal reflux disease (GERD) which does not respond to pantoprazole alone. It provides relief from symptoms of acid reflux disease like heartburn and chest discomfort. Both the medicines, together work by reducing the amount of acid produced in the stomach and improves the motility in the gut. Thus, it reduces the backflow of stomach content to the food pipe. Domperidone+Pantoprazole is available in the form of tablet, capsule. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting domperidone+pantoprazole.


Uses of Domperidone+Pantoprazole

Domperidone+Pantoprazole is used to treat gastrointestinal reflux disease (GERD), not responding to pantoprazole alone.

Contraindications of Domperidone+Pantoprazole

When should one not use Domperidone+Pantoprazole

  • If you are allergic to pantoprazole+domperidone or similar medicines
  • If you are pregnant, planning to get pregnant or are breastfeeding.
  • If you are taking any medications containing rilpivirine
  • If you are suffering from bleeding in the digestive system.
  • If you have any tumour of the pituitary gland (prolactin pituitary tumours)
  • If you have problems with your heart, liver or kidney.

Side effects of Domperidone+Pantoprazole

Common side effects of this drug are:

  • Dry mouth
  • Weakness
  • Diarrhoea
  • Headache
  • Skin rashes
  • Altered taste

Precautions and Warnings of Domperidone+Pantoprazole



Can I take domperidone+pantoprazole during pregnancy?
It is not advised to take pantoprazole+domperidone during pregnancy until it is considered essential by the doctor and potential risks justify the benefits.

Breast Feeding

Can I take domperidone+pantoprazole while breastfeeding?
Pantoprazole+Domperidone passes in the breastmilk in a small amount. Your doctor may prescribe you this medicine while you are breastfeeding, only if it is necessary. Inform your doctor if you are a nursing mother.


Can I drive if I have consumed domperidone+pantoprazole?
Pantoprazole+Domperidone may cause dizziness, thus you need to be cautious while driving.


Can I consume alcohol with domperidone+pantoprazole?
Avoid consuming alcohol with pantoprazole+domperidone, as it may worsen the side effects.

Other General Warnings

Talk to your doctor if
  • You have problems with your liver or kidney.
  • You are suffering from any heart like heart failure, heart rhythm problems, electrolyte imbalance
  • You have a stomach tumour/cancer
  • You develop watery/black stools or fever after taking this medicine.
  • You have low levels of vitamin B12
  • You have a history of fractures or have osteoporosis or are taking steroids.
  • You are taking medicines to treat HIV.
  • You get rashes on your skin on exposure to sun after taking this medicine.
  • Your blood magnesium levels may drop, if you are taking this medicine for more than three months. Your doctor may perform regular tests.
  • Taking pantoprazole+domperidone for more than one year may increase the chances of developing bone fractures.

Mode of Action of Domperidone+Pantoprazole

How Does It Work?

  • A pump called the proton pump in the stomach is responsible for the secretion of stomach acids. Pantoprazole binds to this proton pump in stomach cells, thus blocking acid secretion.
  • Domperidone increases the motility of the stomach and intestines so that acid does not reflux back into the food pipe.

Interactions of Domperidone+Pantoprazole

Interactions with other medicines

  • Some medicines can affect the way domperidone+pantoprazole works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Especially if you are taking medicine to treat your heart problems, mental health problems, fungal or bacterial infections or are taking blood thinners.
  • Rilpivirine or methotrexate should not be used along with this medicine.

Dosage of Domperidone+Pantoprazole


Overdose symptoms may lead to uncontrolled muscle movements, aggression, fits, sleepiness, slurred speech, anxiety etc.

Missed a Dose

If you have missed any dose of pantoprazole+domperidone then take it as soon as you remember. If it is already time for the next dose then skip the missed dose and follow the regular dosing schedule. ...
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Content Details


Dr. Mansi Savla

B. Pharm, PharmD


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: In which all dosage forms is domperidone+pantoprazole available?

A: Domperidone+Pantoprazole is available in the form of tablet, capsule

Q: What is gastro-intestinal reflux disorder (GERD)?

A: There is a valve-like structure in between stomach and food pipe, which allows food to pass from food pipe into the stomach. In Gastro-intestinal reflux disorder (GERD), the acid from the stomach, goes back, upwards in the food pipe. This acid then causes chest discomfort, pain, burping and damage to the food pipe.
Last Updated on: 07 Dec 2021 | 12:15 PM (IST)

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