Trigulin 2mg Tablet
By GLENMARK PHARMACEUTICALS
10 Tablet(s) in Strip
₹292.16
✱
₹332.00
12% OFF
₹29.22/tablet
(Inclusive of all taxes)
✱
Offer applicable on order above ₹100015 days return policyRead More
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Description
Trigulin Tablet contains a combination of glimepiride, metformin, and pioglitazone as its active ingredients. It is used for the treatment of type 2 diabetes mellitus. Trigulin is an antidiabetic med
ication that lowers elevated blood glucose levels. You must adhere to a healthy diet and exercise alongside the medication. Trigulin must be taken as directed by your doctor, in the doses and duration prescribed. Before using the Trigulin Tablet, inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding, and provide detailed medical history. An individual with uncontrolled diabetes is at increased risk of various health complications such as eye, kidney, and nerve issues, heart diseases, and stroke.
Product Summary
| Offer Price | ₹292.16 |
| You Save | ₹39.84 (12% on MRP) |
| Contains | Glimepiride(2.0 Mg)+Metformin Hydrochloride(500.0 Mg)+Pioglitazone(15.0 Mg) |
| Uses | Type 2 diabetes |
| Side effects | Hypoglycemia, headache, nausea, vomiting |
| Therapy | ANTI-DIABETIC |
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Uses
Trigulin Tablet is used to treat type 2 diabetes mellitus; when diet, exercise and Glimepiride, Metformin combination or any other second line treatment is not able to control the blood sugar levels adequately....
Contraindications
- If you are allergic to metformin, pioglitazone, glimepiride, or any other ingredient of Trigulin Tablet.
- If you have class III or IV heart failure.
- If you are pregnant or breastfeeding.
- If you have serious kidney failure or liver failure.
- If you have any metabolic acidosis (too much acid in the body fluids) like lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
- If you have dehydration, severe infections, shock and injections containing iodine.
- If you have had heart or lung failure, a recent incidence of heart attack and shock due to lack oxygen supply.
- If you are an alcoholic.
Side effects
- Hypoglycaemia (low blood sugar)
- Eye disorders
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Loss of appetite
- Metallic taste
- Fractures
- Upper respiratory tract infection
- Headache
- Muscle pain
Precautions and Warnings
Pregnancy
Q:
Can I take Trigulin Tablet during pregnancy?
A:
Trigulin Tablet should not be used during pregnancy as it may cause harm to the unborn baby. Inform your doctor if you are planning a pregnancy, they might suggest some other alternative.
Breast Feeding
Q:
Can I take Trigulin Tablet while breastfeeding?
A:
Trigulin Tablet should not be used during breastfeeding to prevent harm to the new born baby. Inform your doctor if you are a nursing mother.
Driving
Q:
Can I drive if I have consumed Trigulin 2mg Tablet?
A:
- Trigulin Tablet can cause low blood sugar levels which can lead to drowsiness, unconsciousness, visual disturbance or confusion. These can be dangerous while driving.
- Consult your doctor whether you can drive a car if you have frequent episodes of hypoglycemia.
- Keep a juice or chocolate in the car close to you while driving, in case you start feeling any of the above symptoms of hypoglycemia, immediately have the juice or chocolate.
- Note that artificial sweeteners are not of any use in such scenarios.
Alcohol
Q:
Can I consume alcohol with Trigulin 2mg Tablet?
A:
- It is not advisable to consume alcohol during treatment with Trigulin Tablet.
- Alcohol alters the way this medicine works. Be cautious not to consume alcohol on an empty stomach. Alcohol increases the risk of low blood sugar.
- Excessive consumption of alcohol when taking this medicine can cause serious complications known as ketoacidosis.
Other General Warnings
Talk to your doctor if
- You have fluid retention, swelling or heart failure condition.
- You are an elderly person.
- You have or had bladder cancer or are at risk of developing bladder cancer, liver disease.
- You experience sudden weight gain, changes in blood parameters.
- You experience or have any eye disorder or visual disturbances.
- You have weak bones or are prone to fractures.
- You experience extreme hunger, headache, nausea, vomiting, sleepiness, restlessness, aggression, reduced alertness, confusion, shakiness or dizziness. These could be signs of low blood sugar. If you have any of these, immediately have sugar or sweet juice. Inform your doctor as you may need a change in your medicine's dose....
- You are experiencing pins-and-needles sensation, numbness and weakness.
- You are going to have a diagnostic imaging test that involves an injection of iodine.
- You have dehydration due to diarrhoea, vomiting or limited fluid intake.
- You have suffered through trauma.
- You have to undergo surgery in the near future.
- You have serious kidney problems, or undiagnosed blood in urine.
- You have thyroid disorders.
- You are overweight (specific diet restriction may be suggested).
Mode of Action
How Does It Work?
- Glimepiride lowers the blood sugar level increasing release of insulin hormone from the pancreas. Insulin moves sugar (glucose) from the blood into the cells.
- Metformin decreases the absorption in the intestine and production of sugar by the liver.
- Pioglitazone acts by improving the sensitivity of liver (hepatic) and peripheral (muscle) tissue to insulin
- All of these components are known to increase the insulin sensitivity of the body (allows the cells of the body to use blood glucose more effectively, reducing blood sugar).
Directions for Use
- Trigulin Tablet should be taken as directed by your doctor.
- Swallow it as a whole with a glass of water. Take it at a fixed time for optimal results.
- Do not consume it more than that prescribed by your doctor.
Interactions
Interactions with other medicines
- Some medicines can affect the way Trigulin Tablet works or Trigulin itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are on other blood sugar medicine, heart medicine, blood pressure medicine, antibiotics, painkillers, medicine used to treat brain related disorder, blood thinners, antacids, or immunomodulatory medicines....
Storage and disposal
- Store Trigulin Tablet at room temperature in a cool and dry place.
- Protect it from light and moisture.
- Keep it out of the reach of children and pets.
Dosage
Overdose
- Overdose of Trigulin Tablet may cause hypoglycemia (low blood sugar levels), nausea, vomiting, lactic acidosis (excessive lactic acid build-up), headache, dizziness, etc.
- If you experience these, immediately take glucose or juice or sugar-containing products (Sugar candy).
- Contact your doctor immediately or visit the nearest hospital if you have taken too much of this medicine.
Missed a Dose
- A missed dose may lead to high blood sugar levels, which includes symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness, a fruity smell from breath, etc.
- If you have missed any dose of this medicine, take it as soon as you remember.
- If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule.
- Do not take a double dose of this medicine to compensate for the missed one.
Content Details
WRITTEN BY
Dr. Mansi Savla
B. Pharm, PharmD
REVIEWED BY
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Can I stop taking Trigulin if my blood sugar level comes in control?
A: Keep taking Trigulin Tablet for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own. Abrupt discontinuation can worsen the condition.
Q: Can the Trigulin Tablet cause stomach upset?
A: Yes, the Trigulin may cause a stomach upset, though not everyone experiences it. You should continue taking this medicine. Discuss with your doctor in case of a severe stomach upset.
References
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- TRI-AZULIX tablet [Internet]. Torrentian.com. 2022 [cited 3 June 2022]
- Amaryl MP tablet [Internet]. Sanofi.in. 2022 [cited 3 June 2022]
- CDSCO [Internet]. Cdsco.gov. 2022 [cited 3 June 2022]
- Kim JM, Kim SS, Kim JH, Kim MK, Kim TN, Lee SH, Lee CW, Park JY, Kim ES, Lee KJ, Choi YS, Kim DK, Kim IJ. Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study. Diabetes Metab J. 2020 Feb;44(1):67-77. [cited 27 Feb 2025]
- Ragazzi E, Burlina S, Cosma C, Chilelli NC, Lapolla A, Sartore G. Anti-diabetic combination therapy with pioglitazone or glimepiride added to metformin on the AGE-RAGE axis: a randomized prospective study. Front Endocrinol (Lausanne). 2023 Aug 11;14:1163554.[cited 27 Feb 2025]
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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