Trac 4 Strip Of 6 Tablets

• As per CDSCO, TRAC 4 is used in:
• Treatment of Tuberculosis

• This tablet is contraindicated in:
• Hypersensitivity reactions to any of the medications or components of this tablet
• Acute liver disease (regardless of origin), History of medicine-induced liver dysfunction
• Severe kidney failure
• A hereditary disorder called porphyria
• Use in children below 8 years of age
• This tablet in this dosage should not be used in patients who weigh more than 130kg
• Pre-existing eye conditions
• History of rare disorders which affect galactose metabolism (galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption)

• Common side effects of all these medications include:
• Tiredness
• Drowsiness
• Headache
• Giddiness
• Itching, Skin rashes
• Loss of appetite
• Nausea, Vomiting
• Abdominal pain
• Rifampicin can cause:
• Increase in liver enzymes
• Reddening of eyes
• Reddish discolouration of body fluids and secretions (e.g., urine, saliva, sweat, tears, etc.)
• Permanent discolouration of soft contact lenses
• Decreased platelet counts (thrombocytopenia)
• Isoniazid can cause:
• Disturbances of liver function (increase in levels of liver enzymes)
• Loss of sensation in feet and palms, leading to peripheral nerve dysfunction (neuropathy)
• Optic nerve damage and visual changes
• Increased incidence of seizures in epileptics
• Hormonal disturbances, Menstrual irregularities
• Pyrazinamide can cause:
• Increase in uric acid levels, resulting in gout, which presents as severe pain, redness, and swelling of joints.
• Ethambutol can cause:
• Peripheral neuritis (presents as numbness, tingling, burning pain, or weakness in hands or feet)
• Retro-bulbar optic neuritis, which presents as blurred vision, eye pain, red-green colour blindness, loss of vision
• Hallucinations

How Does It Work?

• This medication should be taken as prescribed by the treating physician.
• It is recommended to take this medication on a regular schedule. Taking the tablet at the same time every day is advisable.
• Swallow this medication as a whole. Do not crush, chew, or break this tablet.
• This medication should be taken along with other antitubercular medication, as recommended by your doctor.
• It is recommended to finish the full course of this medication as prescribed by your treating doctor. Abrupt stoppage of the medicine can cause the recurrence of symptoms of the disease. Consult your ...

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• It can be taken with or without food.
• Inform your doctor regarding other medications you may be taking in order to review and prevent any medicine interaction associated effects.

Interactions with other medicines

• Rifampicin is a potent inducer of a particular enzyme system that is involved in metabolising many medications. Concurrent use will hence decrease the efficacy of the other medicines.
• Use of the following medicinal products concomitantly with Trac 4 is not recommended: nevirapine, simvastatin, oral contraceptives, and ritonavir
• Antacids reduce the amount of rifampicin, isoniazid and ethambutol that is absorbed from the gut to the bloodstream. To avoid this, Trac 4 should be taken at least 1 hour before antacids.
• Corticosteroids can reduce the plasma levels of isoniazid by increasing its metabolic and excretion.
• Plasma concentrations of morphine may be reduced by rifampicin. The analgesic effect of morphine should be monitored, and doses of morphine adjusted during and after treatment with rifampicin.
• Rifampicin may reduce the effectiveness of oral contraceptives, and Pyrazinamide decreases the contraceptive effect of oestrogens. Patients treated with Trac 4 should use a non-hormonal method of cont...

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• Oral typhoid vaccine might be inactivated by concomitant antibiotic administration.
• This medication decreases the effect of medicines used to treat gout, such as probenecid and sulfinpyrazone, which are uricosuric agents (increase the excretion of uric acid from the body).

Interactions with food items

• This medication is recommended to be taken 30 mins before food or 2 hours after food.
• Food items that are rich in tyramine, such as cured meat, some cheeses (e.g., matured cheeses), wine, beer and some fish (e.g., tuna, mackerel, salmon), should be avoided.
• This is because Isoniazid can decrease the metabolism of tyramine and histamine, resulting in side effects like headache, sweating, flushing, heart palpitations, and fall in blood pressure.

Overdose

Missed a Dose