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Trac 4 Tablet

6 Tablet(s) in Strip
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Trac 4 Tablet Description

Trac 4 is a prescription medication. It is used in the treatment of tuberculosis. It is a fixed-dose combination of 4 medications, namely Rifampicin (150mg), Isoniazid (75mg), Pyrazinamide (400mg), a

nd Ethambutol (275mg). Tuberculosis is a prevalent infectious disease in India. It is caused by a bacterium called Mycobacterium tuberculosis. It primarily affects the lungs but can also affect other organs like bones, spine, gastrointestinal tract, lymph nodes, meninges, etc. In lung TB, patients present with coughs with sputum production lasting for more than 2 weeks, evening fevers, night sweats, and weight loss. If it affects other organs, the symptoms vary. TB is a chronic, severely debilitating infection that requires sustained treatment. The first-line therapy of TB involves the medications Rifampicin, isoniazid, pyrazinamide and ethambutol in appropriate doses. Trac 4 is a combination of all these medicines in a fixed-dose in one tablet. The medication should be taken as recommended by your treating physician. It is generally advisable to take the tablet at the same time every day. It is also recommended to complete the entire course of the medication; abruptly stopping this medicine can cause worsening of symptoms. It is important to review routinely with your doctor while on this medication to monitor disease progression, your tolerance of the medications, any complications etc.


Product Summary

Offer Price₹42.66
You Save₹6.94 (14% on MRP)
ContainsEthambutol(275.0 Mg) + Pyrazinamide(400.0 Mg) + Isoniazid(75.0 Mg) + Rifampicin(150.0 Mg)
UsesTreatment of Tuberculosis
Side effectsNausea, vomiting, abdominal pain, itching, headache, drowsiness, giddiness, fatigue, discolouration of urine/secretions/faeces, liver dysfunction, kidney dysfunction, visual changes, peripheral nerve disorders.
Check more medicines with composition as Ethambutol(275.0 Mg) + Pyrazinamide(400.0 Mg) + Isoniazid(75.0 Mg) + Rifampicin(150.0 Mg)

Uses of Trac 4 Tablet

  • As per CDSCO, TRAC 4 is used in:
  • Treatment of Tuberculosis

Contraindications of Trac 4 Tablet

  • This tablet is contraindicated in:
  • Hypersensitivity reactions to any of the medications or components of this tablet
  • Acute liver disease (regardless of origin), History of medicine-induced liver dysfunction
  • Severe kidney failure
  • A hereditary disorder called porphyria
  • Use in children below 8 years of age
  • This tablet in this dosage should not be used in patients who weigh more than 130kg
  • Pre-existing eye conditions
  • History of rare disorders which affect galactose metabolism (galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption)

Side effects of Trac 4 Tablet

  • Common side effects of all these medications include:
  • Tiredness
  • Drowsiness
  • Headache
  • Giddiness
  • Itching, Skin rashes
  • Loss of appetite
  • Nausea, Vomiting
  • Abdominal pain
  • Rifampicin can cause:
  • Increase in liver enzymes
  • Reddening of eyes
  • Reddish discolouration of body fluids and secretions (e.g., urine, saliva, sweat, tears, etc.)
  • Permanent discolouration of soft contact lenses
  • Decreased platelet counts (thrombocytopenia)
  • Isoniazid can cause:
  • Disturbances of liver function (increase in levels of liver enzymes)
  • Loss of sensation in feet and palms, leading to peripheral nerve dysfunction (neuropathy)
  • Optic nerve damage and visual changes
  • Increased incidence of seizures in epileptics
  • Hormonal disturbances, Menstrual irregularities
  • Pyrazinamide can cause:
  • Increase in uric acid levels, resulting in gout, which presents as severe pain, redness, and swelling of joints.
  • Ethambutol can cause:
  • Peripheral neuritis (presents as numbness, tingling, burning pain, or weakness in hands or feet)
  • Retro-bulbar optic neuritis, which presents as blurred vision, eye pain, red-green colour blindness, loss of vision
  • Hallucinations

Precautions and Warnings of Trac 4 Tablet



Can I take Trac 4 during pregnancy?
Trac 4 is considered unsafe in pregnancy. Discuss with your doctor, who will weigh the risks and benefits during prescription. Inform your doctor regarding your pregnancy/intention to conceive.

Breast Feeding

Can I take Trac 4 while breastfeeding?
Trac 4 is excreted in breast milk. It is considered unsafe during breastfeeding.


Can I drive if I have taken Trac 4?
Trac 4 may cause drowsiness, giddiness, and fatigue. It is not recommended to drive or operate heavy machinery in case of these adverse effects while using this medication.


Can I consume alcohol with Trac 4?
Consumption of alcohol while using Trac 4 is strictly contraindicated as it may worsen the side effects and can even be life-threatening.

Other General Warnings

Talk to your doctor if
  • You should inform your doctor about any other medications you are taking.
  • You should report to your doctor immediately in case of any worsening of symptoms.

Mode of Action of Trac 4 Tablet

How Does It Work?

The first-line therapy of TB involves the medications Rifampicin, isoniazid, pyrazinamide, and ethambutol in appropriate doses. Trac 4 is a combination of all these medicines in a fixed-dose in one ta...
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Directions for Use of Trac 4 Tablet

  • This medication should be taken as prescribed by the treating physician.
  • It is recommended to take this medication on a regular schedule. Taking the tablet at the same time every day is advisable.
  • Swallow this medication as a whole. Do not crush, chew, or break this tablet.
  • This medication should be taken along with other antitubercular medication, as recommended by your doctor.
  • It is recommended to finish the full course of this medication as prescribed by your treating doctor. Abrupt stoppage of the medicine can cause the recurrence of symptoms of the disease. Consult your ...
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  • It can be taken with or without food.
  • Inform your doctor regarding other medications you may be taking in order to review and prevent any medicine interaction associated effects.

Interactions of Trac 4 Tablet

Interactions with other medicines

  • Rifampicin is a potent inducer of a particular enzyme system that is involved in metabolising many medications. Concurrent use will hence decrease the efficacy of the other medicines.
  • Use of the following medicinal products concomitantly with Trac 4 is not recommended: nevirapine, simvastatin, oral contraceptives, and ritonavir
  • Antacids reduce the amount of rifampicin, isoniazid and ethambutol that is absorbed from the gut to the bloodstream. To avoid this, Trac 4 should be taken at least 1 hour before antacids.
  • Corticosteroids can reduce the plasma levels of isoniazid by increasing its metabolic and excretion.
  • Plasma concentrations of morphine may be reduced by rifampicin. The analgesic effect of morphine should be monitored, and doses of morphine adjusted during and after treatment with rifampicin.
  • Rifampicin may reduce the effectiveness of oral contraceptives, and Pyrazinamide decreases the contraceptive effect of oestrogens. Patients treated with Trac 4 should use a non-hormonal method of cont...
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  • Oral typhoid vaccine might be inactivated by concomitant antibiotic administration.
  • This medication decreases the effect of medicines used to treat gout, such as probenecid and sulfinpyrazone, which are uricosuric agents (increase the excretion of uric acid from the body).

Interactions with food items

  • This medication is recommended to be taken 30 mins before food or 2 hours after food.
  • Food items that are rich in tyramine, such as cured meat, some cheeses (e.g., matured cheeses), wine, beer and some fish (e.g., tuna, mackerel, salmon), should be avoided.
  • This is because Isoniazid can decrease the metabolism of tyramine and histamine, resulting in side effects like headache, sweating, flushing, heart palpitations, and fall in blood pressure.

Storage and disposal of Trac 4 Tablet

Store in a cool and dry place away from direct light and moisture. Do not use the medicine after the expiration date. Keep the tablets away from children and pets. Do not flush the medication down the...
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Dosage of Trac 4 Tablet


As this is a combination of multiple medications, an overdose can present in multiple ways. Possible presenting symptoms can include nausea, vomiting, abdominal pain, pruritus, headache, increasing le...
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Missed a Dose

If you miss a dose of this tablet, it is advised to take it as soon as possible. If the duration missed is too long, and it is almost time for the next dose, it is recommended to skip the missed dose ...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: My urine is reddish-yellow in colour. Should I stop taking this medicine?

A: Reddish-yellow discolouration of bodily fluids and secretions like urine, sweat, tears is a common side effect of using Trac 4. It is harmless. Do not stop this medicine without the directions of your treating physician.

Q: I have a pre-existing liver condition. Can I take this medication?

A: This medication can worsen liver dysfunction. Give your treating physician all relevant health details at the time of prescription. They will be able to evaluate you and prescribe this medication according to your requirements and pre-existing conditions.

Q: Can this medication be used to treat children with tuberculosis?

A: Trac 4 is a fixed-dose combination that is not recommended for children below 8 years of age. The child’s treating doctor will be able to prescribe antitubercular medications of appropriate dose in case of requirement.
Product Details
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Last Updated on: 09 Mar 2022 | 10:32 AM (IST)

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