Pza Ciba 750mg Strip Of 15 Tablets
15 Tablet(s) in StripWe do not sell this product
Made by
ERIS LIFE SCIENCES PVT LTD
Dosage
TABLET
Expiry
Product Summary
| Salt Content | Pyrazinamide(750.0 Mg) |
| Uses | Tuberculosis |
| Therapy | Anti-tubercular |
| Side effects | Nausea, Vomiting, Abdominal pain, Itching, Headache, Drowsiness, Giddiness, Fatigue, Liver dysfunction, Gout |
Assurance
available
Regulated
Medical Description
Pza Ciba is a prescription antibiotic medication used in the management of tuberculosis. The active ingredient of Pza Ciba is Pyrazinamide 750 mg.
Tuberculosis is a common infectious disease in India. It is caused by the bacterium Mycobacterium tuberculosis. It primarily affects the lungs but can also affect other organs like bones, spine, gastrointestinal tract, lymph nodes, meninges, etc. In lung tuberculosis, affected persons present symptoms of cough with sputum for more than two weeks, evening fevers, night sweats, and weight loss.
If the disease affects other organs, the symptoms vary. Tuberculosis is a chronic, severely debilitating infection that requires sustained treatment.
Pyrazinamide is part of the first-line medications used to treat tuberculosis, along with rifampicin, ethambutol, and isoniazid. Pza Ciba should only be given in combination with other anti-tubercular medicines.
The medication should be taken only after consulting a doctor, and the directions for use of Pza Ciba tablets should be strictly followed. It should not be abruptly started or stopped. Taking the tablet at the same time every day is advisable. Side effects of Pza Ciba include tiredness, drowsiness, headache, dizziness, itching, skin rashes, loss of appetite, nausea, vomiting, abdominal pain, etc. It can also lead to an increase in uric acid levels and liver dysfunction.
Uses
- Pza Ciba tablets are used in the treatment of tuberculosis.
Contraindications
- Pyrazinamide is contraindicated:
- If you are hypersensitive to any of the components of this tablet.
- If you have acute liver disease, regardless of origin.
- If you have a history of medicine-induced liver dysfunction.
- If you have a history of gouty arthritis or increased uric acid levels.
- If you have a hereditary blood disorder called porphyria.
- If you have a history of rare disorders that affect galactose metabolism (galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption).
Side effects
- Side effects of Pza Ciba include:
- Tiredness
- Drowsiness
- Headache
- Giddiness
- Dizziness
- Itching
- Skin rashes
- Loss of appetite
- Nausea
- Vomiting
- Abdominal pain
- Bloating
- Increase in uric acid levels (gout as a result requiring treatment and stoppage of the medicine. Gout presents as severe pain, redness, and swelling of joints.)
- Derangement of liver function tests
- Liver dysfunction (symptoms may include fever, generalised tiredness, right upper abdominal pain, jaundice, and enlargement of liver and spleen.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You take medicines for other conditions; it is important for the doctor to rule out any possible medicine interactions before prescribing this medicine.
- You notice a worsening of symptoms.
Directions for Use
- Pza Ciba should be taken as prescribed by the treating physician.
- It is recommended to take this medication on a regular schedule. Taking the tablet at the same time every day is advisable.
- Swallow this medication as a whole. Do not crush, chew or break this tablet.
- This medication should be taken along with other anti-tubercular medications, as prescribed by the doctor.
- It is vital that the entire course of treatment is completed. Abrupt stoppage of the medicine can cause the recurrence of symptoms of the disease. Consult your doctor before stopping this medication.
- Pza Ciba can be taken with or without food.
- Inform your doctor regarding any other medication you take. Your doctor will review them to check for any potential medicine interaction associated effects.
Storage and disposal
Store in a cool and dry place, away from direct light and moisture. Do not use the medicine after its date of expiration. Keep the tablets away from children and pets. Do not flush the medication down the toilet. Dispose of it with biomedical waste.
Dosage
Overdose
An overdose of Pyrazinamide can result in marked hyperuricemia (increased uric acid levels) and severe liver failure. In case of a suspected overdose, rush the affected person to a tertiary care centre with ICU facilities for further evaluation and treatment.
Missed a Dose
If you miss a dose of this tablet, it is advised to take it as soon as possible. If the duration missed is too long and it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular dosing schedule. Do not take a double dose to compensate for the missed dose.
Mode of Action
How Does It Work?
Pyrazinamide is different from other anti-tubercular medications because of its unique mechanism of action. It plays a key role in decreasing the overall duration of tuberculosis therapy. Pyrazinamide causes bacterial destruction by triggering many processes such as energy production, replication and, in particular, the production of a specific enzyme that ensures the continued survival of the bacteria. These effects make Pyrazinamide an essential inclusion in any combinations used to treat tuberculosis, including medicine-resistant variants of tuberculosis.
Interactions
Interactions with other medicines
- This medication decreases the effect of medicines used to treat gout, such as probenecid and sulfinpyrazone, which are uricosuric agents (increase the excretion of uric acid from the body).
- Pyrazinamide decreases the contraceptive effect of oestrogens.
- Oral typhoid vaccine might be inactivated by concomitant antibiotic administration.
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Manufacturer Details
Brand:PZA CIBA
Vendor Details
Fulfillment Information: Pza Ciba 750 MG Tablet (15) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- PYRAZINAMIDE Tablet [Internet]. dailymed.nlm.nih.gov. 2022 [cited 25 February 2022]
- Zinamide Tablets: Summary of Product Characteristics (SmPC) - (emc) [Internet]. medicines.org.uk. 2022 [cited 25 February 2022] -
- Padda IS, Muralidhara Reddy K. Antitubercular Medications [Updated 25 Nov 2021]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 25 February 2022]
- Zhang Y, Shi W, Zhang W, and Mitchison D. Mechanisms of Pyrazinamide Action and Resistance. 2013. Microbiology Spectrum, 2(4): 1–12 [cited 25 February 2022] -
- National Center for Biotechnology Information. PubChem Compound Summary for CID 1046, Pyrazinamide [Internet] PubChem [cited 25 February 2022] -
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
